In major depression, complex intersections between adverse childhood experiences and negative life events impact neuroticism, brooding, suicidal tendencies, insomnia, and cognitive interference

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 7, 2024

Abstract Background There is evidence that adverse childhood experiences (ACEs) and negative life events (NLEs) are associated with major depression (MDD). Purpose To determine whether ACEs affect all features of mild MDD, including suicidal tendencies, brooding, neuroticism, insomnia, cognitive deficits, severity anxiety, NLEs mediate these effects. Patients methods This study examines a cohort 118 academic students, namely 74 students who satisfied the DSM-5-TR criteria for MDD 44 normal control students. We assessed ideation attempts, depression, Stroop tests. Results One validated factor could be extracted from current behaviors, labeled phenome depression. A large part variance in (55.0%) was explained by combined effects self-, relationships, academic-related conjunction ACEs, family dysfunction abuse neglect (both physical emotional). The latter significantly interacted (moderating effect) to impact phenome. Although sexual did not have direct on phenome, its were mediated NLEs. discovered increased abuse, emotional neglect, related predicted 22.5% Up 18.5% test scores scores. Conclusion Complex intersections between which comprises while together other may interference inhibition.

Language: Английский

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The recurrence of illness (ROI) index is a key factor in major depression that indicates increasing immune-linked neurotoxicity and vulnerability to suicidal behaviors

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 13, 2024

Abstract Background The first author of this paper introduced new precision nomothetic models for a major depressive episode (MDD) which incorporate quantitative scores that measure recurrence illness (ROI). Objective To explore the connections between ROI and biomarkers related to an activated immune network, immune-linked neurotoxicity (INT), combined INT atherogenicity index (METAMMUNE). Methods study involved 67 healthy controls 66 outpatient MDD (OMDD) participants. We utilized Multiplex method 48 cytokines, developed METAMMUNE composite scores. measurements included triglycerides, free cholesterol, LDL HDL-cholesterol, apolipoprotein (Apo)A1 ApoB. Results A was successfully created by extracting validated principal component, from number physician-rated episodes, frequency lifetime suicidal ideation attempts. Adverse childhood experiences accounted 20-22% variance in ROI. latter significantly associated with indices, neuroticism, current behaviors, phenome (p<0.001). Our analysis revealed significant portion (55.1%) OMDD phenome, includes anxiety, depression, can be regression on INT, ROI, emotional neglect abuse. latent construct extracted three components, indices. Conclusions immune-metabolic are indicators shared underlying concept, specifically ROI-neuroimmune-metabolic pathway phenotype. is crucial indicator rising abnormalities heightened susceptibility tendencies illness.

Language: Английский

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The Recurrence of Illness (ROI) Index is a Key Factor in Major Depression that Indicates Increasing Immune-Linked Neurotoxicity and Vulnerability to Suicidal Behaviors

Published: Jan. 1, 2024

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Language: Английский

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Do viral-associated pathways underlie the immune activation during the acute phase of severe major depression?

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 6, 2024

Abstract Background Major depressive disorder (MDD) and its most severe phenotype, major dysmood (MDMD), are distinguished by the activation of immune-inflammatory response system, T cell activation, a relative regulatory suppression. Nevertheless, these immune data were not used to characterize features protein-protein interaction (PPI) network MDMD. Objectives To identify network’s nodes bottlenecks as well biological processes that overrepresented in PPI network, we conducted annotation, enrichment analyses. Results The analysis has identified following backbone genes: tumor necrosis factor-α (TNF), interleukin (IL)6, CXCL12, CXCL10, CCL5, cluster differentiation (CD)4, CD8A, human leukocyte antigen (HLA)-DR, FOXP3. A “cellular defense response”, an “immune system “a viral process involves protein with cytokines cytokine receptors” all highly associated network. chemokine TNF nuclear factor-κB (NFKB) pathways additional enriched Molecular complex detection extracted one component from data, including receptors “regulated RELA” (an NFKB subunit). Conclusions Viral may underlie cells networks Future research on pathogenesis MDMD MDD should examine whether which infections onset conditions, or reactivation is recurrence illness.

Language: Английский

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Do viral-associated pathways underlie the immune activation during the acute phase of severe major depression?

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 3, 2024

Background Major depressive disorder (MDD) and its most severe phenotype, major dysmood (MDMD), are distinguished by the activation of immune-inflammatory response system, T cell activation, a relative regulatory suppression. Nevertheless, these immune data were not used to characterize features protein-protein interaction (PPI) network MDMD. Objectives To identify network's nodes bottlenecks as well biological processes that overrepresented in PPI network, we conducted annotation, enrichment analyses. Results The analysis has identified following backbone genes: tumor necrosis factor-α (TNF), interleukin (IL)6, CXCL12, CXCL10, CCL5, cluster differentiation (CD)4, CD8A, human leukocyte antigen (HLA)-DR, FOXP3. A “cellular defense response”, an “immune system “a viral process involves protein with cytokines cytokine receptors” all highly associated network. chemokine TNF nuclear factor-κB (NFKB) pathways additional enriched Molecular complex detection extracted one component from data, including receptors “regulated RELA” (an NFKB subunit). Conclusions Viral may underlie cells networks Future research on pathogenesis MDMD MDD should examine whether which infections onset conditions, or reactivation is recurrence illness.

Language: Английский

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Immune-related gene characterization and biological mechanisms in major depressive disorder revealed based on transcriptomics and network pharmacology

Frontiers in Psychiatry, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 6, 2024

Major depressive disorder (MDD) is a severe psychiatric characterized by complex etiology, with genetic determinants that are not fully understood. The objective of this study was to investigate the pathogenesis MDD and explore its association immune system identifying hub biomarkers using bioinformatics analyses examining infiltrates in human autopsy samples.

Language: Английский

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