Cornelia
de
Lange
Sendromu
(CdLS),
nadir
görülen
bir
genetik
bozukluk
olup
bilişsel
ve
fiziksel
gelişim
geriliği
ile
karakterizedir.
Sensory
Activation
Solutions
(SAS),
müzik
ses
temelli
nöral
aktivasyon
sistemi
olarak
beyindeki
sinir
ağlarını
güçlendirmeyi
süreçleri
iyileştirmeyi
amaçlamaktadır.
Bu
çalışma,
yarı
deneysel
yöntem
kullanılarak
tek
denekli
araştırma
deseni
çerçevesinde
gerçekleştirilmiştir.
Araştırmada,
CdLS
tanılı
üç
yaşındaki
çocuğun
toplam
kürden
oluşan
SAS
dinleti
programına,
her
biri
21
gün
sürecek
şekilde
günde
30
dakika
katılımı
incelenmiştir.
Müdahale
sonrası
becerilerinde
%10-15
oranında
ilerleme
kaydedilmiştir.
bulgular,
tabanlı
nöromodülasyonun
gibi
karmaşık
durumlarda
terapötik
potansiyel
taşıdığını
gösterebilir.
Brain Sciences,
Journal Year:
2025,
Volume and Issue:
15(4), P. 357 - 357
Published: March 29, 2025
Background/Objectives:
Parkinson's
disease
(PD)
is
a
complex
neurodegenerative
disorder
responsible
for
both
motor
and
non-motor
disturbances
impairing
behavior.
This
complexity
necessitates
integrated,
multidisciplinary,
comprehensive
models
of
care.
A
new
interesting
complementary
approach
represented
by
"Dance
Well",
i.e.,
an
artistic,
multisensory
dance
intervention
based
on
art
music.
pilot
study
aims
to
evaluate
the
efficacy,
feasibility,
safety
4-week
Dance
Well
(DW)
program
in
PD
patients
early-medium
stages.
Methods:
Twenty-four
(H&Y
≤
3;
MoCA
score
≥
13.8)
were
enrolled
randomly
allocated
into
two
groups,
with
twice-per-week
frequency
lasting
4
weeks:
one
group
underwent
DW
program,
while
other
conventional
physiotherapy
(CPT).
Demographic,
biometric,
clinical
data
collected.
To
treatment
effect,
(Unified
Rating
Scale-III,
Timed
Up
Go
Test,
Berg
Balance
Scale,
6-Minute
Walk
Falls
Efficacy
Scale),
cognitive
(Corsi
Supra
Span
Trail
Making
Test
B-A),
emotional-motivational
(Beck
Depression
Inventory,
State-Trait
Anxiety
Apathy
Evaluation
Scale)
outcome
measures
assessed,
before
after
rehabilitation
program.
compliance
safety,
number
dropouts
any
adverse
events
(such
as
injuries
falls)
recorded.
Results:
All
improved
groups.
The
percentage
improvement
assessing
attention
motivation
was
greater
group.
No
dropouts,
falls,
or
occurred.
Conclusions:
In
stages
PD,
could
be
considered
feasible
safe
treatment,
useful
improving
motor,
cognitive,
symptoms.
Psycho-Oncology,
Journal Year:
2025,
Volume and Issue:
34(4)
Published: April 1, 2025
ABSTRACT
Background
Bereaved
parents
have
significantly
higher
morbidity
and
mortality
than
non‐bereaved
parents.
Despite
national
guidelines
recommending
bereavement
care,
resources
for
bereaved
are
scarce.
Most
intervention
studies
lack
empirical
evidence
of
effectiveness
or
alignment
with
key
theoretical
concepts.
Aims
To
evaluate
the
feasibility
a
6‐week
children
who
died
from
cancer.
Storytelling
Through
Music
(STM)
combines
multiple
modalities
expression
(storytelling,
reflective
writing,
songwriting)
psychoeducation
to
facilitate
loss‐
restoration‐oriented
coping
by
creating
legacy
piece
(self‐written
story
paired
song)
help
adapt
life‐long
process
finding
meaning
after
loss.
Methods
Two‐group,
randomized
controlled
trial,
utilizing
methods.
Participants
were
STM
waitlist
control.
The
is
delivered
online
in
group
setting.
Descriptive
statistics
used
data,
content
analysis
open‐ended
acceptability
questions,
RM
ANOVA
differences
between
psychosocial,
coping,
grief
outcomes.
Results
Twenty‐three
enrolled.
Average
age
was
(range:
32–68)
child's
average
18.9
1.5–35).
This
study
indicates
that
delivery
feasible
acceptable
provides
preliminary
reducing
prolonged
loneliness.
Conclusions
theoretically
driven,
innovative
approach
addressing
high‐risk,
underserved
population.
Findings
suggest
can
be
participants.
Adding
music
storytelling
writing
unique
data
suggests
improvements
psychosocial
well‐being,
intensity.
Noise and Health,
Journal Year:
2024,
Volume and Issue:
26(122), P. 259 - 265
Published: July 1, 2024
Background:
Hyperbaric
oxygen
therapy
(HBOT),
which
is
widely
used
in
clinical
practice,
aimed
at
improving
nerve
function
impairment
after
brain
injury.
Meanwhile,
the
effects
of
music
on
are
unclear.
This
retrospective
study
was
conducted
to
explore
application
effect
HBOT
combined
with
patients
suffering
from
aneurysmal
subarachnoid
hemorrhage
(aSAH).
Methods:
For
this
study,
130
aSAH
were
selected
our
hospital
June
2021
2022.
The
divided
into
observation
(
n
=
70)
and
control
60)
groups
based
whether
they
received
therapy.
Comparisons
made
general
demographic
data,
blood
flow
rate
median
cerebral
artery
(MCA),
vasospasm
(CVS),
National
Institutes
Health
Stroke
Scale
(NIHSS),
activities
daily
living
(ADL)
score,
Self-Rating
Depressive
(SDS),
Anxiety
(SAS)
patients.
Results:
Baseline
data
between
two
showed
no
statistically
significant
difference
P
>
0.05).
After
management,
group
presented
significantly
lower
SAS
SDS
scores
<
0.05),
MCA,
CVS
NIHSS
higher
ADL
than
Conclusions:
combination
can
considerably
improve
neurological
deficits,
slow
down
arterial
flow,
promote
recovery
postoperative
patients,
anxiety
depression
patients’
ADL.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(24), P. 13614 - 13614
Published: Dec. 19, 2024
Neuroimmunology
is
reshaping
the
understanding
of
central
nervous
system
(CNS),
revealing
it
as
an
active
immune
organ
rather
than
isolated
structure.
This
review
delves
into
unprecedented
discoveries
transforming
field,
including
emerging
roles
microglia,
astrocytes,
and
blood–brain
barrier
(BBB)
in
orchestrating
neuroimmune
dynamics.
Highlighting
their
dual
both
repair
disease
progression,
we
uncover
how
these
elements
contribute
to
intricate
pathophysiology
neurodegenerative
diseases,
cerebrovascular
conditions,
CNS
tumors.
Novel
insights
microglial
priming,
astrocytic
cytokine
networks,
meningeal
lymphatics
challenge
conventional
paradigms
privilege,
offering
fresh
perspectives
on
mechanisms.
work
introduces
groundbreaking
therapeutic
innovations,
from
precision
immunotherapies
controlled
modulation
BBB
using
nanotechnology
focused
ultrasound.
Moreover,
explore
fusion
with
neuromodulatory
technologies,
underscoring
new
frontiers
for
personalized
medicine
previously
intractable
diseases.
By
synthesizing
advancements,
propose
a
transformative
framework
that
integrates
cutting-edge
research
clinical
translation,
charting
bold
path
toward
redefining
management
era
neuroimmunology.
Sensors,
Journal Year:
2024,
Volume and Issue:
24(15), P. 4814 - 4814
Published: July 24, 2024
Movement
sonification
has
emerged
as
a
promising
approach
for
rehabilitation
and
motion
control.
Despite
significant
advancements
in
sensor
technologies,
challenges
remain
developing
cost-effective,
user-friendly,
reliable
systems
gait
detection
sonification.
This
study
introduces
novel
wearable
personalised
biofeedback
device
to
enhance
movement
awareness
individuals
with
irregular
posture.
Through
the
integration
of
inertial
measurement
units
(IMUs),
MATLAB,
sophisticated
audio
feedback
mechanisms,
offers
real-time,
intuitive
cues
facilitate
correction
improve
functional
mobility.
Utilising
single
attached
L4
vertebrae,
system
captures
kinematic
parameters
generate
auditory
through
discrete
continuous
tones
corresponding
heel
strike
events
sagittal
plane
rotations.
A
preliminary
test
that
involved
20
participants
under
various
conditions
was
conducted
assess
system's
accuracy,
reliability,
user
synchronisation.
The
results
indicate
improvement
facilitated
by
cues.
suggests
potential
enhancing
balance,
particularly
beneficial
compromised
or
those
undergoing
process.
paper
details
development
process,
experimental
setup,
initial
findings,
discussing
future
research
directions.
It
also
presents
providing
real-time
about
their
potentially
enabling
them
make
immediate
adjustments
posture
movement.
Future
should
evaluate
this
method
varied
real-world
settings
populations,
including
elderly
Parkinson's
disease.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 31, 2024
Abstract
Objective
We
are
developing
a
new
closed-loop
brain
stimulation
method
by
embedding,
within
music,
auditory
elements
that
respond
to
the
listener’s
activity.
Here
we
show
this
brain-responsive
music
has
systematic
and
targeted
effects
on
neural
oscillations
implicated
in
variety
of
neurological
mental
health
disorders.
Approach
recorded
magnetoencephalogram
(MEG)
or
electroencephalogram
(EEG)
signals
from
participants
as
they
listened
synthesized
commercial
audio
software.
Brain
were
bandpass
filtered,
phase-shifted
used
control
timbre
and/or
timing
notes
music.
Main
results
Listening
induced
peaks
troughs
spectral
power
at
frequencies
depended
systematically
phase-shift
applied
signal.
Phase-dependent
modulation
was
greatest
centre
frequency
filter.
As
result,
calibrating
these
parameters
could
achieve
selective
enhancement
suppression
either
theta
(5
Hz)
alpha
(10
oscillations.
Moreover,
chosing
different
sensor
locations
target
frontal
temporal
cortex.
The
phase-dependent
observed
with
significantly
attenuated
when
identical
conventional,
open-loop
stimulus.
Finally,
demonstrate
activity
be
modulated
more
complex
compositions
combining
musical
controlled
wireless,
wearable
EEG
headband
suitable
for
home
use.
Significance
Brain-responsive
provides
an
unobtrusive
modulating
brain,
may
enable
both
creative
therapeutic
applications
Computer
Interface
technologies.
Cureus,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 10, 2024
Pregnancy
can
heighten
anxiety
levels,
impacting
both
maternal
and
fetal
well-being.
This
systematic
review
synthesizes
evidence
from
33
randomized
controlled
trials
exploring
the
effects
of
music
therapy
on
in
pregnant
women.
The
studies
included
diverse
populations,
ranging
women
undergoing
vitro
fertilization
(IVF)
to
those
facing
high-risk
pregnancies.
Music
interventions
varied
widely,
including
virtual
reality
experiences,
classical
music,
lullabies,
patient-selected
administered
at
different
pregnancy
stages
such
as
IVF
treatments,
elective
cesarean
sections,
hospitalizations.
findings
consistently
demonstrated
that
significantly
reduces
levels
Positive
outcomes
reductions
state
trait
anxiety,
improved
rates,
enhanced
maternal-fetal
parameters.
Additionally,
showed
promise
reducing
during
labor,
deliveries,
hospital
stays.
These
their
positive
highlight
potential
an
effective,
non-pharmacological
approach
managing
pregnancy-related
anxiety.
provides
a
comprehensive
overview
existing
therapy's
efficacy
alleviating
pregnancy.
It
underscores
need
for
further
research
standardize
incorporate
into
routine
prenatal
care.
By
enhancing
overall
well-being
expectant
mothers,
could
become
valuable
adjunct
conventional
care
practices.