Effectiveness of Fecal Microbiota Transplantation in Nociplastic Pain Management: A Systematic Review

Gastrointestinal Disorders, Journal Year: 2025, Volume and Issue: 7(1), P. 5 - 5

Published: Jan. 8, 2025

Nociplastic pain, commonly observed in conditions such as Fibromyalgia, chronic fatigue syndrome, and irritable bowel arises from altered central pain processing involves complex mechanisms, including interactions between the gut–brain axis immune dysregulation. Conventional therapies often fail to address this type of effectively, leading interest alternative approaches fecal microbiota transplantation. This technique has been proposed restore gut microbial balance modulate systemic inflammation, neuroinflammation, neurotransmitter signaling. systematic review, conducted according Preferred Reporting Items for Systematic Reviews Meta-analyses guidelines registered International Prospective Register (CRD42024611939), evaluated 13 studies with n = 409 participants, clinical trials, case reports, retrospective analyses. A quality assessment was performed using appraisal tools Cochrane RoB 2, ROBINS-I, NOS, CARE. The results suggest that transplantation may reduce intensity improve life, particularly patients Fibromyalgia syndrome. However, outcomes Chronic Fatigue Syndrome psoriatic arthritis were inconsistent limited by methodological flaws, small sample sizes, variability protocols donor selection. Although adverse events minimal, current evidence is insufficient support widespread use. High-quality, standardized are needed confirm efficacy Until then, its application should remain experimental interpreted caution.

Language: Английский

Distinctive salivary oral microbiome in patients with burning mouth syndrome depending on pain intensity compared to healthy subjects

Journal of Dental Sciences, Journal Year: 2024, Volume and Issue: 20(1), P. 462 - 469

Published: May 24, 2024

Burning moouth syndrome (BMS) is a chronic pain condition similar to neuropathic pain. It characterized by persistent burning sensation in the oral cavity. Despite lack of clarity regarding etiology BMS, recent studies have reported an association between gut microbiome and However, few investigated orofacial pain, such as BMS. This study aimed compare microbial profiles healthy controls (HC) patients with The BMS group was further divided into BMS_low BMS_high groups according intensity. A total 60 (BMS_low, n = 16; BMS_high, 44) 30 HC provided saliva samples, which were sequenced analyzed for V1-V2 region 16S rRNA gene. alpha diversity among three groups. significant difference distribution composition observed HC, revealed Bray-Curtis distance analysis (P < 0.01). At genus level, Prevotella Alloprevotella most abundant genera group. Compared exhibited relatively higher abundance bacterial species. Some bacteria, including spp., exhibit increasing pattern subjective These results suggest potential involvement microbiota pathogenesis. Additionally, variations may occur not only presence or absence but also severity.

Language: Английский