Influencing factors on neurological prognosis after traumatic brain injury and the role of brain tissue oxygen pressure (PbtO2) monitoring DOI
Chunlei Gao,

E P Zhang,

Zhanhua Shi

et al.

American Journal of Translational Research, Journal Year: 2024, Volume and Issue: 16(12), P. 7530 - 7541

Published: Jan. 1, 2024

To identify factors influencing neurological prognosis following traumatic brain injury (TBI) and to analyze the role of tissue oxygen pressure (PbtO2) monitoring in prognostication. In this case-control study, medical records 412 individuals diagnosed with TBI were thoroughly examined analyzed. The patients divided into two groups based on their at three months post-injury: Good Prognosis (n = 321) Poor 91). Demographic clinical characteristics, partial pressure, radiological laboratory findings, treatment interventions, complications compared between groups. Logistic regression analysis was conducted risk for prognosis, predictive value these evaluated using receiver operating characteristic (ROC) curve analysis. study identified associations Injury Severity Score (ISS), Glasgow Coma Scale (GCS), PbtO2 levels, findings (diffuse axonal subarachnoid hemorrhage), parameters (platelet count arterial (PaO2)) TBI. Initial levels demonstrated independent poor outcomes (Area Under Curve (AUC) 0.804). highlights prognostic significance severity, oxygenation, determining Furthermore, emphasize potential as a valuable tool assessment.

Language: Английский

What traditional neuropsychological assessment got wrong about mild traumatic brain injury. IV: clinical applications and future directions DOI
Erin D. Bigler,

Steven Allder,

Benjamin T. Dunkley

et al.

Brain Injury, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 17

Published: April 3, 2025

Part IV concludes this four-part review of 'What Traditional Neuropsychological Assessment Got Wrong About Mild Traumatic Brain Injury,' with a focus on clinical applications and future directions. These reviews have highlighted the limitations traditional neuropsychological assessment methods, particularly in evaluation patient mild traumatic brain injury (mTBI), especially within context all 21st Century advances neuroimaging, quantification network neuroscience. How advanced neuroimaging technology contemporary neuroscience can be applied to assessing mTBI at time along are reviewed. The current status computerized test (CNT) development is reviewed as it applies assessment. Likewise, how various types virtual reality (VR), artificial intelligence (AI), wearable sensors, markerless gaming could enhance CNT tool box some aspirational statements about improvements novel methods developed integrated technologies tailored meet needs patient.

Language: Английский

Citations

1
Spectrum of Magnetic Resonance Imaging Findings in Acute Pediatric Traumatic Brain Injury - A Pictorial Essay DOI Creative Commons
Cristina-Mihaela Popescu, Virginia Marina,

Georgiana Avram

et al.

Journal of Multidisciplinary Healthcare, Journal Year: 2024, Volume and Issue: Volume 17, P. 2921 - 2934

Published: June 1, 2024

Abstract: Head trauma (HT) in pediatric patients is the number one cause of mortality and morbidity children. Although computer tomography (CT) imaging provides ample information assessing acute traumatic brain injuries (TBIs), there are instances when magnetic resonance (MRI) needed. Due to its high sensitivity diagnosing small bleeds, MRI offers a well-documented evaluation primary TBIs. Our pictorial essay aims present some latest protocols employed head review practical considerations. Injury mechanisms accidental HT, lesions' topography, hematoma signal variability over time also discussed. Acute intra- extra-axial lesions their aspect showcased using images from our hospital. This has an educational purpose. It intended guide young emergency intensive care unit doctors, neurologists, neurosurgeons TBIs on while waiting for official radiologist's report. The presentation focuses most frequent encountered trauma. Keywords: paediatric trauma, injury, diffuse axonal haemorrhagic cortical contusions, epidural haematoma

Language: Английский

Citations

5
NHE1 Protein in Repetitive Mild TBI-Mediated Neuroinflammation and Neurological Function Impairment DOI Open Access

John P. Bielanin,

Shamseldin Metwally, Helena Oft

et al.

Published: April 22, 2024

Mild traumatic brain injuries (mTBIs) are highly prevalent and can lead to chronic behavioral cognitive deficits, often associated with the development of neurodegenerative diseases. The formation reactive oxygen species (ROS) oxidative stress have been implicated in mTBI-mediated axonal injury pathogenesis. However, underlying mechanisms contributing factors not completely understood. In this study, utilizing a murine model repetitive mTBI (r-mTBI) involving five closed-skull concussions young adult C57BL/6J mice, we observed significant elevation Na+/H+ exchanger protein (NHE1) expression GFAP+ astrocytes, IBA1+ microglia, OLIG2+ oligodendrocytes across various regions (including cerebral cortex, corpus callosum, hippocampus). This was accompanied by astrogliosis, microgliosis accumulation amyloid precursor (APP). Concurrently, r-mTBI mice displayed impaired motor learning spatial memory deficits. post-r-mTBI administration potent NHE1 inhibitor, HOE642, attenuated locomotor functional deficits as well gliosis, stress, damage, white matter damage. These findings underscore role upregulation r-mTBI-induced suggesting promising therapeutic target alleviate mTBI-induced restore neurological function.

Language: Английский

Citations

1
NHE1 Protein in Repetitive Mild TBI-Mediated Neuroinflammation and Neurological Function Impairment DOI Creative Commons

John P. Bielanin,

Shamseldin Metwally, Helena Oft

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(7), P. 836 - 836

Published: July 13, 2024

Mild traumatic brain injuries (mTBIs) are highly prevalent and can lead to chronic behavioral cognitive deficits often associated with the development of neurodegenerative diseases. Oxidative stress formation reactive oxygen species (ROS) have been implicated in mTBI-mediated axonal injury pathogenesis. However, underlying mechanisms contributing factors not completely understood. In this study, we explore these pathogenic utilizing a murine model repetitive mTBI (r-mTBI) involving five closed-skull concussions young adult C57BL/6J mice. We observed significant elevation Na

Language: Английский

Citations

0
Influencing factors on neurological prognosis after traumatic brain injury and the role of brain tissue oxygen pressure (PbtO2) monitoring DOI
Chunlei Gao,

E P Zhang,

Zhanhua Shi

et al.

American Journal of Translational Research, Journal Year: 2024, Volume and Issue: 16(12), P. 7530 - 7541

Published: Jan. 1, 2024

To identify factors influencing neurological prognosis following traumatic brain injury (TBI) and to analyze the role of tissue oxygen pressure (PbtO2) monitoring in prognostication. In this case-control study, medical records 412 individuals diagnosed with TBI were thoroughly examined analyzed. The patients divided into two groups based on their at three months post-injury: Good Prognosis (n = 321) Poor 91). Demographic clinical characteristics, partial pressure, radiological laboratory findings, treatment interventions, complications compared between groups. Logistic regression analysis was conducted risk for prognosis, predictive value these evaluated using receiver operating characteristic (ROC) curve analysis. study identified associations Injury Severity Score (ISS), Glasgow Coma Scale (GCS), PbtO2 levels, findings (diffuse axonal subarachnoid hemorrhage), parameters (platelet count arterial (PaO2)) TBI. Initial levels demonstrated independent poor outcomes (Area Under Curve (AUC) 0.804). highlights prognostic significance severity, oxygenation, determining Furthermore, emphasize potential as a valuable tool assessment.

Language: Английский

Citations

0