Boosting Psychotherapy With Noninvasive Brain Stimulation: The Whys and Wherefores of Modulating Neural Plasticity to Promote Therapeutic Change DOI Creative Commons
Daniele Saccenti, Leonor J. Romero Lauro, Sofia Crespi

et al.

Neural Plasticity, Journal Year: 2024, Volume and Issue: 2024(1)

Published: Jan. 1, 2024

The phenomenon of neural plasticity pertains to the intrinsic capacity neurons undergo structural and functional reconfiguration through learning experiential interaction with environment. These changes could manifest themselves not only as a consequence various life experiences but also following therapeutic interventions, including application noninvasive brain stimulation (NIBS) psychotherapy. As standalone therapies, both NIBS psychotherapy have demonstrated their efficacy in amelioration psychiatric disorders’ symptoms, certain variability terms effect sizes duration. Consequently, scholars suggested convenience integrating two interventions into multimodal treatment boost prolong outcomes. Such an approach is still its infancy, physiological underpinnings substantiating effectiveness utility combined are be clarified. Therefore, this opinion paper aims provide theoretical framework consisting compelling arguments why adding can promote change. Namely, we will discuss effects thus providing rationale explain potential advantages approach.

Language: Английский

Decoding Neural Circuit Dysregulation in Bipolar Disorder: Toward an Advanced Paradigm for Multidimensional Cognitive, Emotional, and Psychomotor Treatment DOI Creative Commons

Luca Steardo,

Martina D’Angelo, Francesco Monaco

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2025, Volume and Issue: 169, P. 106030 - 106030

Published: Feb. 1, 2025

Bipolar disorder (BD) is characterized by a complex constellation of emotional, cognitive, and psychomotor disturbances, each deeply intertwined with underlying dysfunctions in large-scale brain networks neurotransmitter systems. This manuscript integrates recent advances neuroimaging, neuromodulation, pharmacological research to provide comprehensive view BD's pathophysiology, emphasizing the role network-specific their clinical manifestations. We explore how dysregulation within fronto-limbic network, particularly involving prefrontal cortex (PFC) amygdala, underpins emotional instability that defines both manic depressive episodes. Additionally, impairments central executive network (CEN) default mode (DMN) are linked cognitive deficits, hyperactivity DMN driving rumination inflexibility, while CEN underactivity contributes attentional lapses impaired function. Psychomotor symptoms, which oscillate between mania retardation depression, closely associated imbalances systems, dopamine serotonin, basal ganglia-thalamo-cortical motor pathway. Recent studies indicate these disturbances further exacerbated disruptions connectivity, leading control regulation. Emerging therapeutic strategies discussed, focus on neuromodulation techniques such as transcranial magnetic stimulation (TMS) deep (DBS), show promise restoring balance critical networks. Furthermore, interventions modulate synaptic functioning neuronal plasticity offer potential for addressing symptoms BD. underscores need an integrative treatment approach simultaneously targets neural circuits systems address full spectrum Drawing advancements neurobiological models frameworks, this proposal outlines pathway development precision-tailored interventions. These approaches designed optimize outcomes, ultimately striving elevate quality life individuals living bipolar (BD), remaining firmly grounded latest empirical evidence theoretical insights.

Language: Английский

Citations

1
Individualised Transcranial Magnetic Stimulation Targeting of the Left Dorsolateral Prefrontal Cortex for Enhancing Cognition: A Randomised Controlled Trial DOI Creative Commons
Donel Martin, Yon Su,

Ho Fung Chan

et al.

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(4), P. 299 - 299

Published: March 22, 2024

Repetitive transcranial magnetic stimulation (rTMS) has been demonstrated to produce cognitive enhancing effects across different neuropsychiatric disorders; however, so far, these have limited. This trial investigated the efficacy of using a novel individualised approach target left dorsolateral prefrontal cortex (L-DLPFC) for flexibility based on performance task. First, forty healthy participants had their single site at L-DLPFC determined each individual’s random letter generation Participants then received, in cross-over single-blinded experimental design, session intermittent theta burst (iTBS) DLPFC site, an active control and sham iTBS. Following treatment condition, completed Task Switching task Colour–Word Stroop test. There was no significant main effect condition primary outcome measure switch reaction times from [F = 1.16 (2, 21.6), p 0.33] or any secondary measures. The current results do not support use our targeting methodology participants. Research into alternative methodological approaches is required further improve rTMS’s effects.

Language: Английский

Citations

8
Interpersonal neural synchrony and mental disorders: unlocking potential pathways for clinical interventions DOI Creative Commons
Kerstin Konrad, Christian Gerloff, Simon H. Kohl

et al.

Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: March 11, 2024

Introduction Interpersonal synchronization involves the alignment of behavioral, affective, physiological, and brain states during social interactions. It facilitates empathy, emotion regulation, prosocial commitment. Mental disorders characterized by interaction dysfunction, such as Autism Spectrum Disorder (ASD), Reactive Attachment (RAD), Social Anxiety (SAD), often exhibit atypical with others across multiple levels. With introduction “second-person” neuroscience perspective, our understanding interpersonal neural (INS) has improved, however, so far, it hardly impacted development novel therapeutic interventions. Methods To evaluate potential INS-based treatments for mental disorders, we performed two systematic literature searches identifying studies that directly target INS through neurofeedback (12 publications; 9 independent studies) or stimulation techniques (7 studies), following PRISMA guidelines. In addition, narratively review indirect manipulations biofeedback, hormonal We discuss ASD, RAD, SAD using a database search assess acceptability (4 neurostimulation in patients dysfunction. Results Although behavioral approaches, engaging eye contact cooperative actions, have been shown to be associated increased INS, little is known about long-term consequences Few proof-of-concept utilized techniques, like transcranial direct current neurofeedback, showing feasibility preliminary evidence interventions can boost synchrony connectedness. Yet, optimal protocols parameters are still undefined. For SAD, far no randomized controlled trial proven efficacy intervention although general methods seem well accepted these patient groups. Discussion Significant work remains translate into effective disorders. Future research should focus on mechanistic insights technological advancements, rigorous design standards. Furthermore, will key compare targeting those other modalities define dyads clinical

Language: Английский

Citations

6
The resting-state brain activity and connectivity mediates the effect of overt narcissism on negative physical self DOI
Xin‐hui Xie, Linlin Fan,

Ximei Chen

et al.

Behavioural Brain Research, Journal Year: 2025, Volume and Issue: unknown, P. 115546 - 115546

Published: March 1, 2025

Language: Английский

Citations

0
Cognitive Outcomes After Transcranial Magnetic Stimulation for the Treatment of Late-Life Depression: Résultats cognitifs après la stimulation magnétique transcrânienne pour le traitement de la dépression chez les personnes âgées DOI Creative Commons

Katharina Göke,

Shawn M. McClintock, Linda Mah

et al.

The Canadian Journal of Psychiatry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 29, 2025

Background Late-life depression (LLD) is often accompanied by cognitive impairment, which may persist despite antidepressant treatment. Repetitive transcranial magnetic stimulation (rTMS) an efficacious treatment for depression, with potential benefits on functioning. However, research effects inconclusive, relatively sparse in LLD, and predominantly focused group-level changes. This study aimed to explore individual-level changes following rTMS patients LLD. Method Data were analyzed from 153 LLD the FOUR-D (ClinicalTrials.gov identifier: NCT02998580) who received bilateral standard or theta burst (TBS) targeting dorsolateral prefrontal cortex (DLPFC). Cognitive function was assessed pre- post-treatment using measures of executive function, information processing speed, learning memory. Reliable change indices, adjusted practice test-retest reliability, employed evaluate Chi-square tests examined if proportions improvers differed expected proportions. Results performance baseline end remained stable most patients. Reliably improved observed 0.0% 20.0% participants across measures, while worsened 2.7%. A small but significant proportion (20.0%) showed improvement verbal learning. Conclusions Bilateral TBS DLPFC yielded no substantial enhancing effects, although a after Importantly, both interventions cognitively safe time. Future needed approaches enhance

Language: Английский

Citations

0
Consensus review and considerations on TMS to treat depression: A comprehensive Update Endorsed by the National Network of depression Centers, the clinical TMS Society, and the International Federation of clinical Neurophysiology DOI Creative Commons
Nicholas T. Trapp, Anthony Purgianto, Joseph J. Taylor

et al.

Clinical Neurophysiology, Journal Year: 2024, Volume and Issue: 170, P. 206 - 233

Published: Dec. 20, 2024

Language: Английский

Citations

3
Ischemic core detection threshold of computed tomography perfusion (CTP) in acute stroke DOI
Luigi Asmundo, Moreno Zanardo, Massimo Cressoni

et al.

La radiologia medica, Journal Year: 2024, Volume and Issue: 129(10), P. 1522 - 1529

Published: Aug. 20, 2024

Language: Английский

Citations

0
Commentary on “Cortical stimulation depth of nTMS investigated in a cohort of convexity meningiomas above the primary motor cortex” DOI

M Lastilla,

Francesco Carbone

Journal of Neuroscience Methods, Journal Year: 2024, Volume and Issue: 409, P. 110208 - 110208

Published: June 22, 2024

Language: Английский

Citations

0
Effects of repetitive transcranial magnetic stimulation combined with cognitive training for improving response inhibition: A proof-of-concept, single-blind randomised controlled study DOI Creative Commons
Haifeng Jiang, Stevan Nikolin, Adriano H. Moffa

et al.

Behavioural Brain Research, Journal Year: 2024, Volume and Issue: 480, P. 115372 - 115372

Published: Dec. 4, 2024

Language: Английский

Citations

0
Boosting Psychotherapy With Noninvasive Brain Stimulation: The Whys and Wherefores of Modulating Neural Plasticity to Promote Therapeutic Change DOI Creative Commons
Daniele Saccenti, Leonor J. Romero Lauro, Sofia Crespi

et al.

Neural Plasticity, Journal Year: 2024, Volume and Issue: 2024(1)

Published: Jan. 1, 2024

The phenomenon of neural plasticity pertains to the intrinsic capacity neurons undergo structural and functional reconfiguration through learning experiential interaction with environment. These changes could manifest themselves not only as a consequence various life experiences but also following therapeutic interventions, including application noninvasive brain stimulation (NIBS) psychotherapy. As standalone therapies, both NIBS psychotherapy have demonstrated their efficacy in amelioration psychiatric disorders’ symptoms, certain variability terms effect sizes duration. Consequently, scholars suggested convenience integrating two interventions into multimodal treatment boost prolong outcomes. Such an approach is still its infancy, physiological underpinnings substantiating effectiveness utility combined are be clarified. Therefore, this opinion paper aims provide theoretical framework consisting compelling arguments why adding can promote change. Namely, we will discuss effects thus providing rationale explain potential advantages approach.

Language: Английский

Citations

0