The mediating role of trait mental fatigue in cognitive decline among PwMS: Implications for verbal memory and information processing speed DOI Creative Commons

Nefeli Tsoukaki,

Alexandra Anagnostopoulou, Panagiotis Kartsidis

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 18, 2024

Abstract Trait mental fatigue (MF) and cognitive dysfunction significantly impair the quality of life in people with multiple sclerosis (PwMS), particularly impacting information processing speed (IPS) verbal learning-memory (VL/M). We assessed 66 PwMS 38 healthy controls (HC) via oral form Symbol Digit Modalities Test (SDMT-Of) for IPS, Greek Verbal Learning (GVLT) VL/M, subscale Modified Fatigue Impact Scale (MFIS-c) MF. This aimed at investigating mediating role MF relationship between IPS VL/M PwMS. performed worse than HC across all domains. Mediation analysis, controlling age, sex, education, disease duration, MS-type, revealed a significant effect on became non-significant once was introduced, whereas indirect through remained significant. No mediation effects were observed HC, even after underscoring unique impact MS. study highlights trait deficits among PwMS, suggesting that interventions targeting could enhance performance. The is registered ClinicalTrials.gov Identifier NCT04806568 (https://www.clinicaltrials.gov/study/NCT04806568).

Language: Английский

Investigation of type IV collagen biomarkers in multiple sclerosis DOI
Signe Holm Nielsen,

Camilla Bramlev,

M.A. Karsdal

et al.

Multiple Sclerosis and Related Disorders, Journal Year: 2025, Volume and Issue: unknown, P. 106436 - 106436

Published: April 1, 2025

Language: Английский

Citations

0
Effect of Aerobic Exercise versus Non-Invasive Brain Stimulation on Cognitive Function in Multiple Sclerosis: A Systematic Review and Meta-Analysis DOI Creative Commons
Mahmoud Elkhooly, Arianna Di Stadio, Evanthia Bernitsas

et al.

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(8), P. 771 - 771

Published: July 30, 2024

In this study, we investigated the effects of noninvasive brain stimulation (NIBS) and exercise on cognition in patients with multiple sclerosis (pwMS).

Language: Английский

Citations

0
The mediating role of trait mental fatigue in cognitive decline among PwMS: Implications for verbal memory and information processing speed DOI Creative Commons

Nefeli Tsoukaki,

Alexandra Anagnostopoulou, Panagiotis Kartsidis

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 18, 2024

Abstract Trait mental fatigue (MF) and cognitive dysfunction significantly impair the quality of life in people with multiple sclerosis (PwMS), particularly impacting information processing speed (IPS) verbal learning-memory (VL/M). We assessed 66 PwMS 38 healthy controls (HC) via oral form Symbol Digit Modalities Test (SDMT-Of) for IPS, Greek Verbal Learning (GVLT) VL/M, subscale Modified Fatigue Impact Scale (MFIS-c) MF. This aimed at investigating mediating role MF relationship between IPS VL/M PwMS. performed worse than HC across all domains. Mediation analysis, controlling age, sex, education, disease duration, MS-type, revealed a significant effect on became non-significant once was introduced, whereas indirect through remained significant. No mediation effects were observed HC, even after underscoring unique impact MS. study highlights trait deficits among PwMS, suggesting that interventions targeting could enhance performance. The is registered ClinicalTrials.gov Identifier NCT04806568 (https://www.clinicaltrials.gov/study/NCT04806568).

Language: Английский

Citations

0