Glutamate transporter activator LDN-212320 prevents chronic pain-induced cognitive impairment and anxiety-like behaviors in a mouse model

Behavioural Brain Research, Journal Year: 2025, Volume and Issue: unknown, P. 115440 - 115440

Published: Jan. 1, 2025

Language: Английский

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A positive allosteric modulator of α7 nicotinic receptor reduces levodopa-induced dyskinesias in hemi-parkinsonian mice

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177655 - 177655

Published: April 1, 2025

Language: Английский

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Neuroinflammation and stress-induced pathophysiology in major depressive disorder: mechanisms and therapeutic implications

Frontiers in Cellular Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: April 23, 2025

Major depressive disorder (MDD) is one of the most common mental health conditions, characterized by pervasive and persistent low mood, self-esteem, a loss interest or pleasure in activities that are typically enjoyable. Despite decades research into etiology pathophysiological mechanisms depression, therapeutic outcomes for many individuals remain less than expected. A promising new area focuses on stress-induced neuroinflammatory processes, such as excessive activation crosstalk microglia astrocytes central nervous system under stress, well elevated levels pro-inflammatory cytokines, which closely linked to onset progression depression. This review summarizes through neuroinflammation induces promotes development also highlights effective roles small molecules with anti-inflammatory activity treatment MDD. Understanding specific further impacts using technologies single-cell RNA sequencing elucidate subtypes interactions great importance developing more strategies

Language: Английский

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Novel Glutamate Transporter Modulator Cefepime Prevents Comorbid Pain and Depressive-Like Behaviors in Mice

Published: Jan. 1, 2025

Language: Английский

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