Intervention modalities for brain fog caused by long-COVID: systematic review of the literature

Neurological Sciences, Journal Year: 2024, Volume and Issue: 45(7), P. 2951 - 2968

Published: May 2, 2024

Language: Английский

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CURRENT CONCEPTS IN LONG-COVID BRAIN FOG AND POSTURAL ORTHOSTATIC TACHYCARDIA SYNDROME

Annals of Allergy Asthma & Immunology, Journal Year: 2024, Volume and Issue: 133(5), P. 522 - 530

Published: Aug. 23, 2024

Language: Английский

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Cognitive Sequelae of COVID‐19: Mechanistic Insights and Therapeutic Approaches

CNS Neuroscience & Therapeutics, Journal Year: 2025, Volume and Issue: 31(3)

Published: March 1, 2025

ABSTRACT Background The COVID‐19 pandemic has left an indelible mark on the world, with mounting evidence suggesting that it not only posed acute challenges to global healthcare systems but also unveiled a complex array of long‐term consequences, particularly cognitive impairment (CI). As persistence post‐COVID‐19 neurological syndrome could evolve into next public health crisis, is imperative gain better understanding intricate pathophysiology CI in patients and viable treatment strategies. Methods This comprehensive review explores management across phases COVID‐19, from infection Long‐COVID, by synthesizing findings clinical, preclinical, mechanistic studies identify key contributors CI, as well current therapeutic approaches. Results Key mechanisms contributing include persistent neuroinflammation, cerebrovascular complications, direct neuronal injury, activation kynurenine pathway, psychological distress. Both pharmacological interventions, such anti‐inflammatory therapies agents targeting neuroinflammatory pathways, non‐pharmacological strategies, including rehabilitation, show promise addressing these challenges. Although much derived preclinical animal studies, provide foundational insights potential Conclusion By knowledge, this highlights importance COVID‐19‐related offers actionable for mitigation recovery community continues grapple pandemic's impact.

Language: Английский

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Updates on the neurological manifestations of SARS-CoV-2 infection

Current Opinion in Infectious Diseases, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Purpose of review Since its emergence in 2020, the COVID-19 pandemic has created a global surge survivors experiencing neurologic effects from SARS-CoV-2 infection. This aims to provide an updated synthesis acute and chronic neurological manifestations COVID-19, outline current therapeutic strategies for these conditions. Recent findings Epidemiological studies have shown that patients with symptoms during infection tend poorer hospital functional outcomes. While risk adverse including cognitive dysfunction, headache, autonomic fatigue are thought be greatest following original strain alpha variant, they remain prevalent after subsequent less virulent strains as well. Some recent work also found link between structural brain changes. However, ongoing trials show promising results pharmacologic nonpharmacologic treatments targeting postacute sequelae COVID-19. Summary Lingering still pose considerable individual, healthcare system, socioeconomic repercussions. Both preventive multimodal treatment approaches necessary address Further research is required assess lasting impacts on nervous particularly potential contribution development neurodegenerative diseases.

Language: Английский

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“Inflammatory Pathways in Patients with Post-acute Sequelae of COVID-19 – The Role of the Clinical Immunologist”

Annals of Allergy Asthma & Immunology, Journal Year: 2024, Volume and Issue: 133(5), P. 507 - 515

Published: Aug. 23, 2024

Language: Английский

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