<i>In silico</i> and <i>in vivo</i> anti-stress potential of <i>Stachytarpheta cayennensis</i> (Verbenaceae) in mice DOI

ItunuOluwa M. Akanmu,

Lateef Abiola Akinpelu,

Abubakar Babando Aliyu

et al.

Nigerian Journal of Pharmacy, Journal Year: 2024, Volume and Issue: 58(2), P. 370 - 385

Published: Nov. 4, 2024

Background: Stachytarpheta cayennensis is locally used as an antistress agent but no scientific rationale for its use. Hence, this study evaluated the potential of ethanol leaf extract (ELSC) in mice. Methods: The stress induced anxiety was assessed using elevated plus maze following acute restraint silico studies previously reported compounds from (S. cayennensis) were also carried out. Results and discussion: There significant (p<0.001) increase status stressed control mice compared to unstressed suggesting induction. However, ELSC at 125 250 mg/kg diazepam significantly reduced indices group reversal stress-induced results revealed betulinic acid most favourable compound terms pharmacokinetics, toxicity profile binding affinity. post docking analysis showed that positive drug (diazepam) interacted with amino residues target receptor protein active pockets. Moreso, has a stronger affinity (-7.8Kcal/Mol) (-6.9 Kcal/Mol), may be more effective than diazepam. Conclusion: This therefore, concluded least part responsible observed effect cayennensis. further out on acid.

Language: Английский

Exercising4Cognition: Can Short Bouts of Aerobic Exercise Improve Cognitive Performance in Healthy Adults for Primary Health Prevention? Previous Findings and Suggestions for the Future DOI Open Access
Cornelia Herbert

Healthcare, Journal Year: 2025, Volume and Issue: 13(4), P. 368 - 368

Published: Feb. 10, 2025

Background: Regular physical activity (PA) and regular exercise (RE) are essential for an active healthy lifestyle. Additionally, the short-term effects have been investigated to understand how acute bout of impacts cognitive processing, important aspect mental health well-being. Previous studies confirmed positive effects. However, several factors human can influence this relationship. Aim/Methods/Results: This perspective paper has three main objectives: firstly, discussing that exercise-cognition significantly across according previous reviews meta-analytic could be explained theoretically; secondly, highlighting knowledge gaps research questions future research; thirdly, what conclusion drawn promotion. A particular focus is given bouts aerobic adults as target group primary prevention. Conclusions: The summary findings shows on performance in depend (a) such duration intensity exercise, (b) type task domain functions, (c) individual individuals. Still, open concern ideal duration, timing exercise. In particular, more needed determine whether exercises short above especially below moderate improve functions adults. Methodologically, these should addressed by multimethod designs consider intra- interindividual comparisons different response levels (self-report, behavioral, psychophysiological). conclusion, answering pave way recommendations healthcare professionals prescribe brief a booster young To end, concepts extended arousal neurovisceral integration useful framework models include factors, like self-regulatory abilities interactions motivation during, pre-to-post testing sessions.

Language: Английский

Citations

0

<i>In silico</i> and <i>in vivo</i> anti-stress potential of <i>Stachytarpheta cayennensis</i> (Verbenaceae) in mice DOI

ItunuOluwa M. Akanmu,

Lateef Abiola Akinpelu,

Abubakar Babando Aliyu

et al.

Nigerian Journal of Pharmacy, Journal Year: 2024, Volume and Issue: 58(2), P. 370 - 385

Published: Nov. 4, 2024

Background: Stachytarpheta cayennensis is locally used as an antistress agent but no scientific rationale for its use. Hence, this study evaluated the potential of ethanol leaf extract (ELSC) in mice. Methods: The stress induced anxiety was assessed using elevated plus maze following acute restraint silico studies previously reported compounds from (S. cayennensis) were also carried out. Results and discussion: There significant (p<0.001) increase status stressed control mice compared to unstressed suggesting induction. However, ELSC at 125 250 mg/kg diazepam significantly reduced indices group reversal stress-induced results revealed betulinic acid most favourable compound terms pharmacokinetics, toxicity profile binding affinity. post docking analysis showed that positive drug (diazepam) interacted with amino residues target receptor protein active pockets. Moreso, has a stronger affinity (-7.8Kcal/Mol) (-6.9 Kcal/Mol), may be more effective than diazepam. Conclusion: This therefore, concluded least part responsible observed effect cayennensis. further out on acid.

Language: Английский

Citations

0