Role of Nanomedicine in Transforming Pharmacotherapy for Substance Use Disorder (SUD) DOI Creative Commons
Akshata Y. Patne, Subhra Mohapatra, Shyam S. Mohapatra

et al.

Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Journal Year: 2025, Volume and Issue: 17(2)

Published: March 1, 2025

ABSTRACT The field of nanomedicine offers revolutionary potential to reshape the discovery and development therapeutics for diverse human diseases. However, its application has been limited in improving Substance Use Disorders (SUDs), which represent a profound public health crisis, including major types such as opioid, alcohol, stimulant, cannabis use disorders. Pharmacotherapy, cornerstone SUD management, reduced morbidity, mortality, societal impact addiction, though efficacy ranged from none moderate. Thus, there is unmet need transform pharmacotherapy curb epidemic addiction. This article explores roles nanomedicine‐inspired precision‐targeted drug delivery, sustained release, combination therapies increase therapeutic minimize side effects. Additionally, it discusses innovative mechanisms that align with neurobiological complexities addiction synergistic approaches integrate behavioral interventions, device‐based therapies, emerging modalities immunotherapy neurostimulation. Despite these advancements, barriers treatment accessibility, adherence challenges, inequitable resource distribution persist, particularly underserved populations. By harnessing transformative capabilities integrating into holistic, equitable, personalized care frameworks, this review highlights path forward revolutionize landscape. underscores continued nano‐SUD research strategies alleviate substantial burden on individuals, families, society.

Language: Английский

Prevalence of Substance Use and Associated Factors Among Secondary School Students in Marrakech Region, Morocco DOI Creative Commons
Abdelmounaim Baslam,

Samia Boussaa,

Karima Raoui

et al.

Psychoactives, Journal Year: 2025, Volume and Issue: 4(1), P. 1 - 1

Published: Jan. 2, 2025

Adolescence is a phase characterized by reckless and risky behaviors, including the initiation use of various illicit substances such as cannabis alcohol. When ingested or administered, these affect mental processes delivering pleasure, inner peace, satisfaction. The aim this study was to determine prevalence associated factors psychoactive substance (PAS) among adolescents. A cross-sectional conducted, 300 participants surveyed using structured questionnaire. Data were collected Mediterranean School Survey Project on Alcohol Other Drugs (MedSPAD) assess use, Diagnostic Statistical Manual Mental Disorders (DSM-5) diagnose disorders (SUDs), Early Trauma Inventory Self-Report Short Form (ETISR-SF) identify childhood maltreatment, well socio-demographic characteristics. During period, secondary school students participated. Their mean age 17.92 ± 1.40 years, ranging from 15 22. There slightly more males (56.7%) than females. total 40.67% admitted at least one PAS once, while current 26%. Tobacco most commonly used (22.1%), followed (7.33%). According DSM-5, 40.2% users met criteria for severe addiction. Factors with included father’s level education; place (e.g., home); poor relationships parents, siblings, teachers; maltreatment. Psychoactive found be prevalent adolescents in study.

Language: Английский

Citations

1
Effects of Physical Exercise on Substance Use Disorder: A Comprehensive Review DOI Creative Commons
Roberto Montón-Martínez,

Ismael Castellano-Galvañ,

Alba Roldán

et al.

Applied Sciences, Journal Year: 2025, Volume and Issue: 15(3), P. 1481 - 1481

Published: Jan. 31, 2025

Physical exercise has emerged as a promising complementary intervention for individuals with substance use disorders (SUD). This comprehensive review examines the neurobiological, psychological, and social benefits of in improving quality life (QOL), mental health, sleep quality, craving, physical fitness, cognitive function among SUD. Aerobic exercises, particularly those moderate intensity, demonstrate consistent efficacy reducing anxiety, depression, cravings, while also enhancing cardiovascular health psychosocial well-being. Strength training concurrent programs provide additional muscular function, although their effects on are less consistent. Mind–body disciplines like yoga Tai Chi offer accessible entry points low baseline fitness but exhibit variable outcomes, especially craving management. High-intensity interval (HIIT) shows potential reduction improvements may pose challenges initial fitness. underscores importance tailored, well-structured that align participants’ needs capabilities. Future research should prioritize standardizing protocols, incorporating technological tools, exploring hybrid models to maximize adherence therapeutic impact. remains vital, multifaceted tool SUD rehabilitation strategies.

Language: Английский

Citations

0
Efficacy and Clinical Application of Physical Activity in Substance Use Disorder Rehabilitation: A Review on Mechanism and Benefits DOI Creative Commons
Gaia Calcini, Vittorio Bolcato, L Tronconi

et al.

Physiologia, Journal Year: 2025, Volume and Issue: 5(1), P. 7 - 7

Published: Feb. 12, 2025

Background: Substance Use Disorders (SUDs) are chronic conditions characterized by high relapse rates and significant psychological, physical, social complications. Despite the availability of traditional pharmacological psychotherapeutic interventions, many individuals struggle to maintain abstinence. Recently, physical activity (PA) has emerged as a promising complementary intervention. This review aims examine existing evidence on effects PA in with SUDs, particular focus neurobiological mechanisms. Methods: A narrative was conducted 30 September 2024, searching relevant keywords PubMed, Web Science, Google Scholar, Scopus. Randomized clinical trials, cohort studies, reviews, meta-analyses published between 1988 2024 were considered. Results: Fifty studies included. Key themes included role inducing neuroadaptation which is crucial for prevention impulse control, depending type specific SUD. Neurobiological modifications related interest search potential biomarkers. Additionally, explored cravings, mental health, quality life. The overall discusses psychological changes induced during SUD rehabilitation, identifies barriers participation programs, suggests organizational strategies enhance adherence. Conclusions: Physical adjunctive therapy management Disorders. Long-time longitudinal needed sustain scientific efficacy. success programs moreover depends overcoming adherence, including logistical challenges.

Language: Английский

Citations

0
A Co-Design Approach to Develop a Motivational Intervention to Promote Physical Activity Engagement and Maintenance Among Individuals in Residential Substance Use Disorder Treatment Settings DOI Creative Commons
Sascha Thal, Stephen Bright, Nikos Ntoumanis

et al.

Psychology of sport and exercise, Journal Year: 2025, Volume and Issue: unknown, P. 102829 - 102829

Published: Feb. 1, 2025

Language: Английский

Citations

0
Role of Nanomedicine in Transforming Pharmacotherapy for Substance Use Disorder (SUD) DOI Creative Commons
Akshata Y. Patne, Subhra Mohapatra, Shyam S. Mohapatra

et al.

Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Journal Year: 2025, Volume and Issue: 17(2)

Published: March 1, 2025

ABSTRACT The field of nanomedicine offers revolutionary potential to reshape the discovery and development therapeutics for diverse human diseases. However, its application has been limited in improving Substance Use Disorders (SUDs), which represent a profound public health crisis, including major types such as opioid, alcohol, stimulant, cannabis use disorders. Pharmacotherapy, cornerstone SUD management, reduced morbidity, mortality, societal impact addiction, though efficacy ranged from none moderate. Thus, there is unmet need transform pharmacotherapy curb epidemic addiction. This article explores roles nanomedicine‐inspired precision‐targeted drug delivery, sustained release, combination therapies increase therapeutic minimize side effects. Additionally, it discusses innovative mechanisms that align with neurobiological complexities addiction synergistic approaches integrate behavioral interventions, device‐based therapies, emerging modalities immunotherapy neurostimulation. Despite these advancements, barriers treatment accessibility, adherence challenges, inequitable resource distribution persist, particularly underserved populations. By harnessing transformative capabilities integrating into holistic, equitable, personalized care frameworks, this review highlights path forward revolutionize landscape. underscores continued nano‐SUD research strategies alleviate substantial burden on individuals, families, society.

Language: Английский

Citations

0