Targeting CB2 receptor with a novel antagonist reverses cognitive decline, neurodegeneration and pyroptosis in a TAU-dependent frontotemporal dementia mouse model
Brain Behavior and Immunity,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 1, 2025
Language: Английский
Acute cannabis intoxication among the paediatric population
Frontiers in Toxicology,
Journal Year:
2025,
Volume and Issue:
7
Published: April 14, 2025
This
narrative
review
synthesizes
the
toxicological,
clinical
and
medico-legal
aspects
of
paediatric
cannabis
intoxication.
By
providing
a
comprehensive
overview,
it
aims
to
inform
future
research,
guide
policymaking,
enhance
toxicological
practice
in
addressing
this
growing
public
health
concern.
The
pharmacokinetics
cannabinoid
ingestion
children
are
significantly
influenced
by
immaturity
their
gastrointestinal
tract
metabolic
enzyme
systems,
resulting
altered
oral
bioavailability.
Clinical
data
indicate
that
Δ9-tetrahydrocannabinol
(THC)-related
effects
paediatricpaediatric
patients
typically
emerge
within
2
hours
ingestion,
with
more
severe
symptoms
developing
4
hours.
endocannabinoid
system
(ECS)
undergoes
significant
developmental
changes,
marked
differences
receptor
expression
distribution
across
fetal,
neonatal,
adult
brains.
During
neurodevelopment,
CB1
receptors
exhibit
unique
patterns,
including
transient
localization
brainstem
regions
critical
for
neurovegetative
functions.
These
dynamics
likely
explain
children’s
heightened
sensitivity
THC’s
neurological
effects,
often
outcomes
compared
adults.
reliable
detection
cannabinoids
involves
integrating
screening
methods
confirmatory
analytical
techniques.
Urine
immunoassay
testing
is
widely
considered
an
helpful
toolto
assess
previous
exposure,
becoming
positive
3–4
h
ingestion.
However,
method
prone
false
positives.
Plasma
THC
concentration,
when
measured
close
event,
offers
valuable
insights
into
quantity
ingested
correlation
between
exposure
impairment
window.
Hair
analysis,
while
useful
distinguishing
acute
chronic
use,
susceptible
various
biases.
rising
incidence
intoxication
underscores
urgent
need
targeted
interventions
stricter
regulatory
frameworks.
Preventive
measures
such
as
child-resistant
packaging,
education
campaigns,
use
during
pregnancy
essential
mitigate
risks.
Clinicians
should
consider
differential
diagnosis
presenting
unexplained
neurological,
immune,
or
symptoms.
Language: Английский
Cannabis, Endocannabinoids and Brain Development: From Embryogenesis to Adolescence
Cells,
Journal Year:
2024,
Volume and Issue:
13(22), P. 1875 - 1875
Published: Nov. 13, 2024
The
endocannabinoid
signalling
system
(ECS)
plays
a
critical
role
from
the
very
beginning
of
embryogenesis.
Accordingly,
ECS
is
engaged
early
on
in
nervous
development,
starting
neurulation,
supported
by
identification
components—both
receptors
and
enzymes
controlling
metabolism—at
these
stages.
In
particular,
regarding
brain,
involved
tightly
regulated
sequence
events
that
comprise
brain
neurogenesis
to
neuronal
migration,
morphological
guidance
for
connectivity,
synaptic
circuitry
refinement.
importance
this
broad
across
various
development
processes
further
underscored
growing
understanding
consequences
cannabis
exposure
at
different
developmental
Despite
considerable
knowledge
we
have
significant
gaps
our
remain,
particularly
long-term
impact
underlying
mechanisms
This
review
provides
an
overview
current
state
throughout
embryogenesis
adulthood,
discusses
exposure,
especially
during
adolescence—a
period
maturation
refinement
coinciding
with
increased
risk
use.
Language: Английский
Unveiling the Potential of Phytocannabinoids: Exploring Marijuana’s Lesser-Known Constituents for Neurological Disorders
Biomolecules,
Journal Year:
2024,
Volume and Issue:
14(10), P. 1296 - 1296
Published: Oct. 13, 2024
Cannabis
sativa
is
known
for
producing
over
120
distinct
phytocannabinoids,
with
Δ
Language: Английский
Cannabinoids for treating psychiatric disorders in youth: a systematic review of randomized controlled trials
Patrick Köck,
No information about this author
Andrzej Badek,
No information about this author
Maximilian Meyer
No information about this author
et al.
Child and Adolescent Psychiatry and Mental Health,
Journal Year:
2024,
Volume and Issue:
18(1)
Published: Dec. 18, 2024
Abstract
Background
Cannabinoids
have
been
of
increasing
interest
mainly
due
to
their
putative
efficacy
in
a
wide
array
psychiatric,
psychosomatic,
and
neurological
conditions.
Aims
This
systematic
review
aims
synthesize
results
from
randomized
placebo-controlled
trials
regarding
the
dosage
cannabinoids
as
therapeutics
psychiatric
disorders
children,
adolescents,
young
adults.
Methods
All
publications
up
June
30th,
2024,
were
included
PubMed
Embase.
Eligibility
criteria
accordance
with
PRISMA-guidelines
was
applied.
RCTs
providing
pre-
post-treatment
parameters
on
cannabinoid
therapies
for
mental
comparison
controls
an
age
range
0
25
years
included.
Effect
sizes
calculated
Hedges’
g
primary
outcomes,
multilevel
random-effects
meta-analysis
conducted
account
dependent
outcomes
same
study
populations.
Results
We
identified
7603
records,
which
8
independent
clinical
(reported
9
publications)
met
pre-established
eligibility
criteria,
comprising
474
unique
participants
(245
treatment,
229
control).
Analysis
13
(of
7
trials)
revealed
modest
positive
overall
effect
symptom
improvement
or
normalization
brain
physiology
(Hedges’
=
0.308,
95%
CI:
0.167,
0.448).
Autism
spectrum
disorder
studies
showed
most
consistent
evidence
(g
0.264,
0.107,
0.421),
while
other
conditions
wider
confidence
intervals.
Age-stratified
analysis
that
adult
populations
(mean
23.3
years,
n
5
outcomes)
demonstrated
higher
0.463,
SD
0.402)
compared
pediatric
11.8
outcomes;
0.318,
0.212).
Whole
plant
preparations
0.328,
0.083,
0.573)
pharmaceutical
0.292,
0.069,
0.515)
comparable
effects.
CBD
dosages
ranged
17.5
mg
600
per
day,
no
significant
correlation
between
size
(ρ
-0.014,
p
0.963).
Mild
moderate
side
effects
reported,
but
serious
adverse
events.
Risk
bias
assessment
low
(
3)
high
5).
Conclusion
While
effects,
particularly
autism
disorders,
current
remains
insufficient
broadly
recommend
treating
youth
Larger,
controlled
standardized
are
needed
establish
definitive
recommendations.
Language: Английский
Role of peroxisome proliferator-activated receptors α and γ in mediating the beneficial effects of β-caryophyllene in a rat model of fragile X syndrome
Progress in Neuro-Psychopharmacology and Biological Psychiatry,
Journal Year:
2024,
Volume and Issue:
136, P. 111234 - 111234
Published: Dec. 24, 2024
β-Caryophyllene
(BCP)
is
a
naturally
occurring
sesquiterpene
found
in
numerous
plant
species,
including
Cannabis
sativa.
BCP
has
shown
high
safety
profile
and
wide
range
of
biological
functions,
beneficial
effects
neurodegenerative
inflammatory
diseases.
Here,
we
used
behavioral,
pharmacological,
in-silico
docking
analyses
to
investigate
the
mechanism
action
Fragile
X
Syndrome
(FXS),
most
common
inherited
cause
Autism
Spectrum
Disorder
(ASD)
intellectual
disability.
To
this
aim,
recently
validated
Fmr1-
Language: Английский