Evolving Landscape of Parkinson’s Disease Research: Challenges and Perspectives
ACS Omega,
Journal Year:
2025,
Volume and Issue:
10(2), P. 1864 - 1892
Published: Jan. 8, 2025
Parkinson's
disease
(PD)
is
a
progressive
neurodegenerative
disorder
that
primarily
affects
movement.
It
occurs
due
to
gradual
deficit
of
dopamine-producing
brain
cells,
particularly
in
the
substantia
nigra.
The
precise
etiology
PD
not
fully
understood,
but
it
likely
involves
combination
genetic
and
environmental
factors.
therapies
available
at
present
alleviate
symptoms
do
stop
disease's
advancement.
Research
endeavors
are
currently
directed
inventing
disease-controlling
aim
inherent
mechanisms
PD.
biomarker
breakthroughs
hold
enormous
potential:
earlier
diagnosis,
better
monitoring,
targeted
treatment
based
on
individual
response
could
significantly
improve
patient
outcomes
ease
burden
this
disease.
research
an
active
evolving
field,
focusing
understanding
mechanisms,
identifying
biomarkers,
developing
new
treatments,
improving
care.
In
report,
we
explore
data
from
CAS
Content
Collection
outline
progress
We
analyze
publication
landscape
offer
perspective
into
latest
expertise
advancements.
Key
emerging
concepts
reviewed
strategies
fight
evaluated.
Pharmacological
targets,
risk
factors,
as
well
comorbid
diseases
explored,
clinical
usage
products
against
with
their
production
pipelines
trials
for
drug
repurposing
examined.
This
review
aims
comprehensive
overview
advancing
current
about
PD,
define
challenges,
assess
growth
prospects
stimulate
efforts
battling
Language: Английский
Advances in Understanding Biomarkers and Treating Neurological Diseases -Role of the Cerebellar Dysfunction and Emerging Therapies
Ageing Research Reviews,
Journal Year:
2024,
Volume and Issue:
unknown, P. 102519 - 102519
Published: Sept. 1, 2024
Language: Английский
Brain Stimulation Techniques in Research and Clinical Practice: A Comprehensive Review of Applications and Therapeutic Potential in Parkinson’s Disease
Brain Sciences,
Journal Year:
2024,
Volume and Issue:
15(1), P. 20 - 20
Published: Dec. 27, 2024
Parkinson's
Disease
(PD)
is
a
progressive
neurodegenerative
disorder
characterized
by
range
of
motor
and
non-motor
symptoms
(NMSs)
that
significantly
impact
patients'
quality
life.
This
review
aims
to
synthesize
the
current
literature
on
application
brain
stimulation
techniques,
including
non-invasive
methods
such
as
transcranial
magnetic
(TMS),
electrical
(tES),
focused
ultrasound
(tFUS),
transcutaneous
vagus
nerve
(tVNS),
well
invasive
approaches
like
deep
(DBS).
We
explore
efficacy
safety
profiles
these
techniques
in
alleviating
both
impairments,
bradykinesia
rigidity,
symptoms,
cognitive
decline,
depression,
impulse
control
disorders.
Current
findings
indicate
while
present
favorable
profile
are
effective
for
milder
DBS
provide
significant
relief
severe
cases
unresponsive
other
treatments.
Future
research
needed
optimize
parameters,
establish
robust
clinical
protocols,
expand
technologies
across
various
stages
PD.
underscores
potential
vital
therapeutic
tool
managing
PD,
paving
way
enhanced
treatment
strategies
improved
patient
outcomes.
Language: Английский