Structural Brain Pattern Abnormalities in Tinnitus with and without Hearing Loss DOI Creative Commons
Qin Li,

Qiu Ge,

Chengchao Shi

et al.

Hearing Research, Journal Year: 2025, Volume and Issue: unknown, P. 109274 - 109274

Published: April 1, 2025

Subjective tinnitus often coexists with hearing loss, and they share common pathophysiological mechanisms. This comorbidity induces whole-brain gray matter volume (GMV) alterations, manifesting as distributed structural changes in neural networks rather than isolated regional modifications. Multivariate analysis of brain patterns is therefore essential to differentiate their underlying Fifty patients 50 age-/gender-matched controls underwent MRI audiometry. Patients were stratified by level into 22 loss (T+HL) 28 without (T-HL). To investigate specific Source-Based Morphometry (SBM), a multivariate analytical approach based on Independent Component Analysis (ICA), was applied identify covarying GMV. The associations between these covariance clinical characteristics examined using Spearman's correlation analysis. Our results showed that T-HL patients, abnormalities the medial prefrontal cortex, precuneus, auditory cortex negatively correlated distress. In contrast, T+HL insular pattern associated depressive symptoms. findings revealed tinnitus-related involve regions such middle frontal gyrus, supplementary motor area (SMA), anterior cingulate (ACC), correlating distress, suggesting adaptive mechanisms perception. Moreover, involving insula, putamen, superior temporal gyrus appears be primarily driven loss. These support audiometric-based subgrouping management.

Language: Английский

Structural Brain Pattern Abnormalities in Tinnitus with and without Hearing Loss DOI Creative Commons
Qin Li,

Qiu Ge,

Chengchao Shi

et al.

Hearing Research, Journal Year: 2025, Volume and Issue: unknown, P. 109274 - 109274

Published: April 1, 2025

Subjective tinnitus often coexists with hearing loss, and they share common pathophysiological mechanisms. This comorbidity induces whole-brain gray matter volume (GMV) alterations, manifesting as distributed structural changes in neural networks rather than isolated regional modifications. Multivariate analysis of brain patterns is therefore essential to differentiate their underlying Fifty patients 50 age-/gender-matched controls underwent MRI audiometry. Patients were stratified by level into 22 loss (T+HL) 28 without (T-HL). To investigate specific Source-Based Morphometry (SBM), a multivariate analytical approach based on Independent Component Analysis (ICA), was applied identify covarying GMV. The associations between these covariance clinical characteristics examined using Spearman's correlation analysis. Our results showed that T-HL patients, abnormalities the medial prefrontal cortex, precuneus, auditory cortex negatively correlated distress. In contrast, T+HL insular pattern associated depressive symptoms. findings revealed tinnitus-related involve regions such middle frontal gyrus, supplementary motor area (SMA), anterior cingulate (ACC), correlating distress, suggesting adaptive mechanisms perception. Moreover, involving insula, putamen, superior temporal gyrus appears be primarily driven loss. These support audiometric-based subgrouping management.

Language: Английский

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