Personalized auricular vagus nerve stimulation: beat-to-beat deceleration dominates in systole-gated stimulation during inspiration - a pilot study DOI Creative Commons
Johanna Tischer, József Constantin Széles, Eugenijus Kaniušas

et al.

Frontiers in Physiology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 6, 2025

Neuromodulation comes into focus as a non-pharmacological therapy with the vagus nerve modulation target. The auricular stimulation (aVNS) has emerged to treat chronic diseases while re-establishing sympathovagal balance and activating parasympathetic anti-inflammatory pathways. aVNS leads still over under-stimulation is limited in therapeutic efficiency. A potential avenue personalization of based on time-varying cardiorespiratory rhythms human body. In pilot study, we propose personalized cardiac-gated evaluate its effects instantaneous beat-to-beat intervals (RR intervals). Modulation RR expected reveal efficiency since efferent cardiac branch stimulated afferent governs RR. Five healthy subjects were subjected aVNS. Each subject underwent two 25-min sessions. first session started non-gated open-loop aVNS, followed by systole-gated closed-loop then non-gated, diastole-gated, each for 5min. second session, systole diastole gated interchanged. Changes are analysed comparing prolongation respect proceeding interval where took place. These changes considered function onset, angle starting R peak. influence respiration phases cardiovagal modulation. results show that tends prolong shorten when after before peak, respectively. later time onset within diastole-gated longer be subsequent interval. tendency raises increasing gradually levels off delay from one slope this rise larger than When considering individual phases, inspiratory seems largest values thus modulatory capacity time-gated This study indicates modulate heartbeat activity which attenuated diseases. highest during inspiration.

Language: Английский

Does transcutaneous auricular vagus nerve stimulation alter pupil dilation? A living Bayesian meta-analysis DOI Creative Commons

Ipek Pervaz,

Lilly Thurn,

Cecilia Vezzani

et al.

Brain stimulation, Journal Year: 2025, Volume and Issue: 18(2), P. 148 - 157

Published: Jan. 29, 2025

Language: Английский

Citations

2
Personalized auricular vagus nerve stimulation: beat-to-beat deceleration dominates in systole-gated stimulation during inspiration - a pilot study DOI Creative Commons
Johanna Tischer, József Constantin Széles, Eugenijus Kaniušas

et al.

Frontiers in Physiology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 6, 2025

Neuromodulation comes into focus as a non-pharmacological therapy with the vagus nerve modulation target. The auricular stimulation (aVNS) has emerged to treat chronic diseases while re-establishing sympathovagal balance and activating parasympathetic anti-inflammatory pathways. aVNS leads still over under-stimulation is limited in therapeutic efficiency. A potential avenue personalization of based on time-varying cardiorespiratory rhythms human body. In pilot study, we propose personalized cardiac-gated evaluate its effects instantaneous beat-to-beat intervals (RR intervals). Modulation RR expected reveal efficiency since efferent cardiac branch stimulated afferent governs RR. Five healthy subjects were subjected aVNS. Each subject underwent two 25-min sessions. first session started non-gated open-loop aVNS, followed by systole-gated closed-loop then non-gated, diastole-gated, each for 5min. second session, systole diastole gated interchanged. Changes are analysed comparing prolongation respect proceeding interval where took place. These changes considered function onset, angle starting R peak. influence respiration phases cardiovagal modulation. results show that tends prolong shorten when after before peak, respectively. later time onset within diastole-gated longer be subsequent interval. tendency raises increasing gradually levels off delay from one slope this rise larger than When considering individual phases, inspiratory seems largest values thus modulatory capacity time-gated This study indicates modulate heartbeat activity which attenuated diseases. highest during inspiration.

Language: Английский

Citations

0