Mitochondrial-based therapies for neurodegenerative diseases: a review of the current literature DOI Creative Commons

Al-Hassan Soliman Wadan,

Ahmed Shaaban, Mohamed El‐Sadek

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: March 31, 2025

Abstract Neurodegenerative disorders present significant challenges to modern medicine because of their complex etiology, pathogenesis, and progressive nature, which complicate practical treatment approaches. Mitochondrial dysfunction is an important contributor the pathophysiology various neurodegenerative illnesses, including Alzheimer’s disease (AD), Parkinson’s (PD), amyotrophic lateral sclerosis (ALS). This review paper examines current literature highlighting multifaceted functions mitochondria, energy production, calcium signaling, apoptosis regulation, mitochondrial biogenesis, dynamics, axonal transport, endoplasmic reticulum–mitochondrial interactions, mitophagy, proteostasis, crucial involvement in neuronal health. The emphasizes increasing recognition as a critical factor progression disorders, marking shift from traditional symptom management innovative mitochondrial-based therapies. By discussing mechanisms, quality control (MQC) processes impact oxidative stress, this highlights need for novel therapeutic strategies restore function, protect connections integrity, slow progression. comprehensive aims provide insights into potential interventions that could transform landscape diseases, addressing symptoms underlying pathophysiological changes.

Language: Английский

Mitochondria transfer for myelin repair DOI Creative Commons
Sabah Mozafari, Luca Peruzzotti-Jametti, Stefano Pluchino

et al.

Journal of Cerebral Blood Flow & Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: March 13, 2025

Demyelination is a common feature of neuroinflammatory and degenerative diseases the central nervous system (CNS), such as multiple sclerosis (MS). It often linked to disruptions in intercellular communication, bioenergetics metabolic balance accompanied by mitochondrial dysfunction cells oligodendrocytes, neurons, astrocytes, microglia. Although current MS treatments focus on immunomodulation, they fail stop or reverse demyelination’s progression. Recent advancements highlight exchange promising therapeutic target, with potential restore homeostasis, enhance promote myelin repair. With this review we will provide insights into CNS decoupling, focusing role demyelinating conditions. We then discuss emerging cell-free biotherapies exploring transferring mitochondria via biogenic carriers like extracellular vesicles (EVs) synthetic liposomes, aimed at enhancing function support for Lastly, address key challenges clinical application these strategies future directions optimize biotherapies. The field hold promise restoring repair, potentially transforming landscape diseases.

Language: Английский

Citations

0
Mitochondrial-based therapies for neurodegenerative diseases: a review of the current literature DOI Creative Commons

Al-Hassan Soliman Wadan,

Ahmed Shaaban, Mohamed El‐Sadek

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: March 31, 2025

Abstract Neurodegenerative disorders present significant challenges to modern medicine because of their complex etiology, pathogenesis, and progressive nature, which complicate practical treatment approaches. Mitochondrial dysfunction is an important contributor the pathophysiology various neurodegenerative illnesses, including Alzheimer’s disease (AD), Parkinson’s (PD), amyotrophic lateral sclerosis (ALS). This review paper examines current literature highlighting multifaceted functions mitochondria, energy production, calcium signaling, apoptosis regulation, mitochondrial biogenesis, dynamics, axonal transport, endoplasmic reticulum–mitochondrial interactions, mitophagy, proteostasis, crucial involvement in neuronal health. The emphasizes increasing recognition as a critical factor progression disorders, marking shift from traditional symptom management innovative mitochondrial-based therapies. By discussing mechanisms, quality control (MQC) processes impact oxidative stress, this highlights need for novel therapeutic strategies restore function, protect connections integrity, slow progression. comprehensive aims provide insights into potential interventions that could transform landscape diseases, addressing symptoms underlying pathophysiological changes.

Language: Английский

Citations

0