AdipoRon’s Impact on Alzheimer’s Disease—A Systematic Review and Meta-Analysis

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 484 - 484

Published: Jan. 8, 2025

Alzheimer's disease (AD) remains a leading cause of cognitive decline and mortality worldwide, characterized by neurodegeneration, synaptic deficiencies, neuroinflammation. Despite advancements in early detection, diagnosis, treatment, AD presents substantial challenges due to its complex pathology, heterogeneity, the limited efficacy current therapies. Consequently, there is pressing need for novel therapeutic agents target multifaceted aspects enhance treatments, minimize adverse effects. AdipoRon, an adiponectin receptor agonist, has garnered interest potential neuroprotective effects, including reducing neuroinflammation, improving mitochondrial function, mitigating tau hyperphosphorylation. This review aimed evaluate effects AdipoRon-based replacement therapy against AD, using comprehensive approach grounded PICO framework-Population, Intervention, Comparison, Outcomes. A total six studies were reviewed, vitro vivo investigations examining AdipoRon's impact on various models. These involved different cell lines transgenic mouse models, assessing outcomes such as phosphorylation, relevant molecular pathways. By synthesizing data from these studies, our thoroughly explains mechanisms action, agent AD. analysis aims highlight state knowledge, identify gaps research, suggest directions future clinical applications.

Language: Английский

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The Peripheral Amyloid-β Nexus: Connecting Alzheimer’s Disease with Atherosclerosis through Shared Pathophysiological Mechanisms

NeuroMolecular Medicine, Journal Year: 2025, Volume and Issue: 27(1)

Published: March 3, 2025

Abstract Alzheimer’s disease (AD) and atherosclerosis (AS) are two chronic diseases with seemingly distinct pathologies. However, emerging research points to a bidirectional relationship driven by common mechanisms, such as inflammation, oxidative stress, dysregulation of Amyloid-Beta (Aβ). This review focuses on the role Aβ critical molecular link between AD AS, emphasizing its contribution neuronal impairment vascular damage. Specifically, peripheral produced in pancreas skeletal muscle tissues exacerbates AS promoting endothelial dysfunction insulin resistance (IR). Furthermore, accelerates progression impairing cerebral blood flow inducing hypoxia, causing accumulation. critically evaluates recent findings, highlighting inconsistencies clinical studies suggesting future directions. Understanding influence could pave way for novel therapeutic approaches targeting shared pathways, particularly clearance inflammation.

Language: Английский

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Response to Intermittent hypoxia and oxidative stress in patients with sleep apnea syndrome

Sleep and Biological Rhythms, Journal Year: 2025, Volume and Issue: 23(2), P. 213 - 214

Published: Jan. 22, 2025

Language: Английский

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