Decoding Microglial Polarization and Metabolic Reprogramming in Neurodegenerative Diseases: Implications for Disease Progression and Therapy DOI Creative Commons
Ran Gao, Ya Gao, Wenting Su

et al.

Aging and Disease, Journal Year: 2025, Volume and Issue: unknown, P. 0 - 0

Published: Jan. 1, 2025

As the resident macrophages of brain, microglia are crucial immune cells specific to central nervous system (CNS). They constantly surveil their surroundings and trigger immunological reactions, playing a key role in various neurodegenerative diseases (ND). illnesses progress, exhibit multiple phenotypes. Traditionally, have been classified into two main phenotypes upon activation: pro-inflammatory M1 polarization anti-inflammatory M2 polarization. However, this classification is now considered overly simplistic, as it unable fully convey intricacy diversity inflammatory response. Immune regulatory factors, such chemokines secreted by microglia, essential for modulating brain development, maintaining neural milieu, orchestrating responses injury, along with subsequent repair processes. recent years, significance metabolic reprogramming both physiological microglial activity ND has also become increasingly recognized. Upon activation-triggered infection, or ND-microglia typically modify processes transitioning from oxidative phosphorylation (OXPHOS) glycolysis. This shift facilitates rapid energy production but may enhance responses. review seeks summarize function involvement ND.

Language: Английский

Decoding Microglial Polarization and Metabolic Reprogramming in Neurodegenerative Diseases: Implications for Disease Progression and Therapy DOI Creative Commons
Ran Gao, Ya Gao, Wenting Su

et al.

Aging and Disease, Journal Year: 2025, Volume and Issue: unknown, P. 0 - 0

Published: Jan. 1, 2025

As the resident macrophages of brain, microglia are crucial immune cells specific to central nervous system (CNS). They constantly surveil their surroundings and trigger immunological reactions, playing a key role in various neurodegenerative diseases (ND). illnesses progress, exhibit multiple phenotypes. Traditionally, have been classified into two main phenotypes upon activation: pro-inflammatory M1 polarization anti-inflammatory M2 polarization. However, this classification is now considered overly simplistic, as it unable fully convey intricacy diversity inflammatory response. Immune regulatory factors, such chemokines secreted by microglia, essential for modulating brain development, maintaining neural milieu, orchestrating responses injury, along with subsequent repair processes. recent years, significance metabolic reprogramming both physiological microglial activity ND has also become increasingly recognized. Upon activation-triggered infection, or ND-microglia typically modify processes transitioning from oxidative phosphorylation (OXPHOS) glycolysis. This shift facilitates rapid energy production but may enhance responses. review seeks summarize function involvement ND.

Language: Английский

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