Neurobiological and Microbiota Alterations After Bariatric Surgery: Implications for Hunger, Appetite, Taste, and Long-Term Metabolic Health DOI Creative Commons
Sebastián Chapela, Ludwig Roberto Álvarez Córdova, Andrés Martinuzzi

et al.

Brain Sciences, Journal Year: 2025, Volume and Issue: 15(4), P. 363 - 363

Published: March 31, 2025

Bariatric surgery (BS) is an effective intervention for obesity, inducing significant neurobiological and gut microbiota changes that influence hunger, appetite, taste perception, long-term metabolic health. This narrative review examines these alterations by analyzing recent findings from clinical preclinical studies, including neuroimaging, microbiome sequencing, hormonal assessments. BS modulates appetite-regulating hormones, reducing ghrelin while increasing glucagon-like peptide-1 (GLP-1) peptide tyrosine-tyrosine (PYY), leading to enhanced satiety decreased caloric intake. Neuroimaging studies reveal structural functional in brain regions involved reward processing cognitive control, contributing reduced cravings altered food choices. Additionally, reshapes the microbiota, beneficial species such as Akkermansia muciniphila, which pathways through short-chain fatty acid production bile metabolism. These highlight complex interplay between post-surgical regulation. Understanding mechanisms essential optimizing post-operative care, nutritional strategies behavioral interventions. Future research should explore how impact outcomes, guiding development of targeted therapies enhance recovery quality life patients.

Language: Английский

Molecular Mechanisms Underlying Neuroinflammation Intervention with Medicinal Plants: A Critical and Narrative Review of the Current Literature DOI Creative Commons
Sandra Maria Barbalho, Beatriz Leme Boaro,

Jéssica da Silva Camarinha Oliveira

et al.

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(1), P. 133 - 133

Published: Jan. 20, 2025

Neuroinflammation is a key factor in the progression of neurodegenerative diseases, driven by dysregulation molecular pathways and activation brain’s immune system, resulting release pro-inflammatory oxidative molecules. This chronic inflammation exacerbated peripheral leukocyte infiltration into central nervous system. Medicinal plants, with their historical use traditional medicine, have emerged as promising candidates to mitigate neuroinflammation offer sustainable alternative for addressing conditions green healthcare framework. review evaluates effects medicinal plants on neuroinflammation, emphasizing mechanisms action, effective dosages, clinical implications, based systematic search databases such PubMed, SCOPUS, Web Science. The findings highlight that like Cleistocalyx nervosum var. paniala, Curcuma longa, Cannabis sativa, Dioscorea nipponica reduce cytokines (TNF-α, IL-6, IL-1β), inhibit enzymes (COX-2 iNOS), activate antioxidant pathways, particularly Nrf2. NF-κB primary pathway inhibited across studies. While anti-inflammatory potential these significant, variability dosages phytochemical compositions limits translation. Here, we are modulators underscoring therapeutic potential. Future research should focus animal models, standardized protocols, safety assessments, integrating advanced methodologies, genetic studies nanotechnology, enhance applicability disease management.

Language: Английский

Citations

2
Effect of nutritional supplements on gut microbiome in individuals with neurodevelopmental disorders: a systematic review and narrative synthesis DOI Creative Commons

Elaheh Dehghani,

Keyvan Karimi,

Soheil Arekhi

et al.

BMC Nutrition, Journal Year: 2025, Volume and Issue: 11(1)

Published: March 29, 2025

Neurodevelopmental disorders (NDDs) encompass a range of disruptive conditions with varying prevalence rates and multiple contributing factors. Recent studies have suggested potential connection between NDDs the gut-brain axis. Furthermore, there is evidence indicating that nutritional supplements might an impact on gastrointestinal (GI) behavioral symptoms. This study aimed to explore effects gut microbiota symptoms in individuals NDDs. A systematic search databases such as PubMed, Scopus, Web Science, Embase, APA PsycINFO was conducted, utilizing relevant keywords until February 2025. In addition, for gray literature carried out Google Scholar ProQuest. The risk bias assessed using ROBINS-I tool non-randomized RoB-1 randomized controlled trials. Due heterogeneity studies, Synthesis without Meta-analysis (SWiM) approach employed. overall findings from indicated positive supplementation reducing Gastrointestinal Severity Index (GIS) score alleviating GI Supplementation probiotics vitamins increased good microbiomes (GM) decrease bad (BM) among autism spectrum disorder (ASD). Moreover, Firmicutes Bacteroidetes ratio (F/R ratio) exhibited significant changes after supplementation. Additionally, improvements were observed various assessment scores, including ATEC, ABC, CARS, PGI-2. Nutritional can influence by modulating microbiome, dysbiosis, enhancing barrier integrity. Shifting F/R be considered reason improving influencing neurotransmitter activity neuroinflammation. Targeting axis interventions focus offers promising adjunct therapy management NDD. Registration review protocol. PROSPERO registration no. CRD42023460449.

Language: Английский

Citations

1
Pathological and Inflammatory Consequences of Aging DOI Creative Commons
Mario García‐Domínguez

Biomolecules, Journal Year: 2025, Volume and Issue: 15(3), P. 404 - 404

Published: March 12, 2025

Aging is a complex, progressive, and irreversible biological process that entails numerous structural functional changes in the organism. These affect all bodily systems, reducing their ability to respond adapt environment. Chronic inflammation one of key factors driving development age-related diseases, ultimately causing substantial decline abilities older individuals. This persistent inflammatory state (commonly known as “inflammaging”) characterized by elevated levels pro-inflammatory cytokines, an increase oxidative stress, perturbation immune homeostasis. Several factors, including cellular senescence, contribute this milieu, thereby amplifying conditions such cardiovascular disease, neurodegeneration, metabolic disorders. Exploring mechanisms chronic aging essential for developing targeted interventions aimed at promoting healthy aging. review explains strong connection between inflammation, highlighting potential therapeutic approaches like pharmacological treatments, dietary strategies, lifestyle changes.

Language: Английский

Citations

0
Neurobiological and Microbiota Alterations After Bariatric Surgery: Implications for Hunger, Appetite, Taste, and Long-Term Metabolic Health DOI Creative Commons
Sebastián Chapela, Ludwig Roberto Álvarez Córdova, Andrés Martinuzzi

et al.

Brain Sciences, Journal Year: 2025, Volume and Issue: 15(4), P. 363 - 363

Published: March 31, 2025

Bariatric surgery (BS) is an effective intervention for obesity, inducing significant neurobiological and gut microbiota changes that influence hunger, appetite, taste perception, long-term metabolic health. This narrative review examines these alterations by analyzing recent findings from clinical preclinical studies, including neuroimaging, microbiome sequencing, hormonal assessments. BS modulates appetite-regulating hormones, reducing ghrelin while increasing glucagon-like peptide-1 (GLP-1) peptide tyrosine-tyrosine (PYY), leading to enhanced satiety decreased caloric intake. Neuroimaging studies reveal structural functional in brain regions involved reward processing cognitive control, contributing reduced cravings altered food choices. Additionally, reshapes the microbiota, beneficial species such as Akkermansia muciniphila, which pathways through short-chain fatty acid production bile metabolism. These highlight complex interplay between post-surgical regulation. Understanding mechanisms essential optimizing post-operative care, nutritional strategies behavioral interventions. Future research should explore how impact outcomes, guiding development of targeted therapies enhance recovery quality life patients.

Language: Английский

Citations

0