Role of STAT3 signaling pathway in breast cancer

Cell Communication and Signaling, Journal Year: 2020, Volume and Issue: 18(1)

Published: Feb. 28, 2020

Abstract Breast cancer has grown to be the second leading cause of cancer-related deaths in women. Only a few treatment options are available for breast due widespread occurrence chemoresistance, which emphasizes need discover and develop new methods treat this disease. Signal transducer activator transcription 3 (STAT3) is an early tumor diagnostic marker known promote malignancy. Recent clinical preclinical data indicate involvement overexpressed constitutively activated STAT3 progression, proliferation, metastasis chemoresistance cancer. Moreover, pathways comprised upstream regulators downstream targets have been discovered. In addition, small molecule inhibitors targeting activation found efficient therapeutic This systematic review discusses advances discovery drugs

Language: Английский

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Circulating biomarkers in patients with glioblastoma

British Journal of Cancer, Journal Year: 2019, Volume and Issue: 122(3), P. 295 - 305

Published: Oct. 31, 2019

Abstract Gliomas are the most common tumours of central nervous system and aggressive form is glioblastoma (GBM). Despite advances in treatment, patient survival remains low. GBM diagnosis typically relies on imaging techniques postoperative pathological diagnosis; however, both procedures have their inherent limitations. Imaging modalities cannot differentiate tumour progression from treatment-related changes that mimic progression, known as pseudoprogression, which might lead to misinterpretation therapy response delay clinical interventions. In addition limitations, tissue biopsies invasive time be performed over course treatment evaluate ‘real-time’ dynamics. an attempt address these liquid been proposed field. Blood sampling a minimally procedure for endure could provide tumoural information guide therapy. Tumours shed content, such circulating cells, cell-free nucleic acids, proteins extracellular vesicles, into circulation, biomarkers reported cross blood–brain barrier. The use emerging field GBM. this review, we aim summarise current literature biomarkers, namely DNA vesicles potential non-invasively sampled manage patients with

Language: Английский

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Functions and clinical significance of circular RNAs in glioma

Molecular Cancer, Journal Year: 2020, Volume and Issue: 19(1)

Published: Feb. 15, 2020

Abstract CircRNAs are a class of single-stranded RNA molecules with covalently closed loop structure and have been characterized by high stability, abundance, conservation, display tissue/developmental stage-specific expression, furthermore, based on the abundance in distinct body fluids or exosomes, circRNAs present novel biomarkers targets for diagnosis prognosis cancers. Recently, regulatory mechanisms biogenesis molecular functions, including miRNAs RBPs sponge, translation as well transcriptional splicing regulation, gradually uncovered, although various aspects remained to be elucidated combination deep-sequence bioinformatics. Accumulating studies indicated that more enriched neuronal tissues partly due specific genes promoting circularization, suggesting dysregulation is closely related diseases nervous system, glioma. In this review, we elaborate biogenesis, databases advances especially involved pathways, highlight its great value diagnostic therapeutic

Language: Английский

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microRNAs (miRNAs) in Glioblastoma Multiforme (GBM)—Recent Literature Review

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(4), P. 3521 - 3521

Published: Feb. 9, 2023

Glioblastoma multiforme (GBM) is the most common, malignant, poorly promising primary brain tumor. GBM characterized by an infiltrating growth nature, abundant vascularization, and a rapid aggressive clinical course. For many years, standard treatment of gliomas has invariably been surgical supported radio- chemotherapy. Due to location significant resistance conventional therapies, prognosis glioblastoma patients very poor cure rate low. The search for new therapy targets effective therapeutic tools cancer current challenge medicine science. microRNAs (miRNAs) play key role in cellular processes, such as growth, differentiation, cell division, apoptosis, signaling. Their discovery was breakthrough diagnosis diseases. Understanding structure miRNAs may contribute understanding mechanisms regulation dependent on miRNA pathogenesis diseases underlying these short non-coding RNAs, including glial tumors. This paper provides detailed review latest reports relationship between changes expression individual formation development gliomas. use this also discussed.

Language: Английский

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Liquid Biopsy in Glioblastoma: Opportunities, Applications and Challenges

Cancers, Journal Year: 2019, Volume and Issue: 11(7), P. 950 - 950

Published: July 5, 2019

Liquid biopsy represents a minimally invasive procedure that can provide similar information from body fluids to what is usually obtained tissue sample. Its implementation in the clinical setting might significantly renew field of medical oncology, facilitating introduction concepts precision medicine and patient-tailored therapies. These advances may be useful diagnosis brain tumors currently require surgery for collection, or perform genetic tumor profiling disease classification guidance therapy. In this review, we will summarize most recent putative applications liquid glioblastoma, common malignant adult tumor. Moreover, discuss remaining challenges hurdles terms technology biology its application.

Language: Английский

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Hsa_circ_0002483 inhibited the progression and enhanced the Taxol sensitivity of non-small cell lung cancer by targeting miR-182-5p

Cell Death and Disease, Journal Year: 2019, Volume and Issue: 10(12)

Published: Dec. 16, 2019

Abstract In this study, we identified a novel circRNA, circ_0002483, and further investigated its functions in the progression Taxol resistance of NSCLC. We found that circ_0002483 was expressed at low levels NSCLC tissues cell lines. Functional assays indicated overexpression significantly inhibited proliferation invasion vitro vivo enhanced sensitivity cells to Taxol. Mechanistically, sponge multiple miRNAs including miR-182-5p (also named miR-182), miR-520q-3p, miR-582-3p, miR-587, miR-655. addition, also demonstrated regulate expression GRB2, FOXO1, FOXO3, three target genes miR-182-5p, by sponging miR-182-5p. Circ_0002483 inhibit release inhibition on FOXO3 mRNAs.

Language: Английский

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The Impact of lncRNAs in Diabetes Mellitus: A Systematic Review and In Silico Analyses

Frontiers in Endocrinology, Journal Year: 2021, Volume and Issue: 12

Published: March 19, 2021

Long non-coding RNAs (lncRNAs) are transcripts that have emerged as one of the largest and diverse RNA families regulate gene expression. Accumulating evidence has suggested a number lncRNAs involved in diabetes mellitus (DM) pathogenesis. However, results about lncRNA expressions DM patients still inconclusive. Thus, we performed systematic review literature on subject followed by bioinformatics analyses to better understand which dysregulated pathways they act. Pubmed, Embase, Gene Expression Omnibus (GEO) repositories were searched identify studies investigated expression cases with non-diabetic controls. LncRNAs consistently submitted analysis retrieve their target genes potentially affected signaling under regulation. Fifty-three eligible articles included this after application inclusion exclusion criteria. Six hundred thirty-eight differentially expressed between controls at least study. Among them, six (Anril, Hotair, Malat1, Miat, Kcnq1ot1, Meg3) compared Moreover, these participate several metabolism-related pathways, evidencing importance DM. This suggests DM, constituting potential biomarkers disease.

Language: Английский

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The Interplay between Glioblastoma Cells and Tumor Microenvironment: New Perspectives for Early Diagnosis and Targeted Cancer Therapy

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(4), P. 331 - 331

Published: March 29, 2024

Glioblastoma multiforme (GBM) stands out as the most tremendous brain tumor, constituting 60% of primary cancers, accompanied by dismal survival rates. Despite advancements in research, therapeutic options remain limited to chemotherapy and surgery. GBM molecular heterogeneity, intricate interaction with tumor microenvironment (TME), non-selective treatments contribute neoplastic relapse. Diagnostic challenges arise from advanced-stage detection, necessitating exploration novel biomarkers for early diagnosis. Using data literature a bioinformatic tool, current manuscript delineates interplay between human GBM, astrocytes, myeloid cells, underscoring selected protein pathways belonging astroglia lineage, which can be considered targeted therapies. Moreover, pivotal role extracellular vesicles (EVs) orchestrating favorable cancer progression is highlighted, suggesting their utility identifying

Language: Английский

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Survival analysis of immune-related lncRNA in low-grade glioma

BMC Cancer, Journal Year: 2019, Volume and Issue: 19(1)

Published: Aug. 16, 2019

Low-grade glioma is grade I-II glioma. Immunotherapy a promising way of tumor killing. Research on immune molecular mechanisms in low-grade gliomas and discovery new checkpoints for are great importance.Gene sequencing data clinical were downloaded from TCGA database. Prognosis related lncRNAs identified by Cox regression their possible functions found gene enrichment set analysis.A total 529 samples 5 non-tumor brain tissue obtained the Two hundred forty-seven immune-associated screened. showed that 16 immune-related associated with prognosis, 7 independent risk factors. Gene analysis suggests these molecules enriched extracellular region, sequence-specific DNA binding, neuropeptide signaling pathway, transcriptional misregulation cancer, cytokine-cytokine receptor interaction, protein digestion absorption, chemokine etc. CONCLUSION: The identification lncRNA may provide targets research treatment

Language: Английский

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The landscape of circRNAs in gliomas temozolomide resistance: Insights into molecular pathways

Non-coding RNA Research, Journal Year: 2024, Volume and Issue: 9(4), P. 1178 - 1189

Published: May 21, 2024

As the deadliest type of primary brain tumor, gliomas represent a significant worldwide health concern. Circular RNA (circRNA), unique non-coding molecule, seems to be one most alluring target molecules involved in pathophysiology many kinds cancers. CircRNAs have been identified as prospective targets and biomarkers for diagnosis treatment numerous disorders, particularly malignancies. Recent research has established clinical link between temozolomide (TMZ) resistance certain circRNA dysregulations glioma tumors. may play therapeutic role controlling or overcoming TMZ provide guidance novel kind individualized therapy. To address biological characteristics circRNAs their potential induce TMZ, this review highlighted summarized possible roles that molecular pathways drug resistance, including Ras/Raf/ERK PI3K/Akt signaling pathway metabolic processes gliomas.

Language: Английский

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