Peritumoral Microenvironment in High-Grade Gliomas: From FLAIRectomy to Microglia–Glioma Cross-Talk DOI Creative Commons
Roberto Altieri, Davide Barbagallo, Francesco Certo

et al.

Brain Sciences, Journal Year: 2021, Volume and Issue: 11(2), P. 200 - 200

Published: Feb. 6, 2021

Cellular composition and molecular signatures of the glioma core compared with infiltrative margins are different, it is well known that tumor edge enriched in microglia. In this review literature, we summarize role peritumoral area high-grade gliomas (HGGs) from surgical biological points view. There evidence on dual microglia HGGs—a scavenger-tumoricidal when activated an M1 phenotype a favoring growth infiltration/migration M2 phenotype. Microglia polarization mediated by complex pathways involving cross-talk cells. scenario, extracellular vesicles their miRNA cargo seem to play central role. The switch specific correlates prognosis pathological assessment microglial setting can predict patient’s outcome. Some authors have designed engineered cell as biologically active vehicle for delivery intraoperative near-infrared fluorescent dye aim helping surgeons detect infiltrated areas during resection. Furthermore, pharmacological modulation microglia-glioma paves way more effective therapies.

Language: Английский

Nanocarrier-based drug combination therapy for glioblastoma DOI Creative Commons
Mengnan Zhao, Demian van Straten, Marike L. D. Broekman

et al.

Theranostics, Journal Year: 2020, Volume and Issue: 10(3), P. 1355 - 1372

Published: Jan. 1, 2020

The current achievements in treating glioblastoma (GBM) patients are not sufficient because many challenges exist, such as tumor heterogeneity, the blood brain barrier, glioma stem cells, drug efflux pumps and DNA damage repair mechanisms.Drug combination therapies have shown increasing benefits against those challenges.With help of nanocarriers, enhancement efficacy safety could be gained using synergistic combinations different therapeutic agents.In this review, we will discuss major issues for GBM treatment, rationales with or without nanocarriers principle enhanced permeability retention effect involved nanomedicine-based targeting promising nanodiagnostics -therapeutics.We also summarize recent progress clinical perspectives nanocarrier-based therapies.The goal article was to provide better understanding key considerations develop new nanomedicine nanotheranostics options fight GBM.

Language: Английский

Citations

293
Mouse models of glioblastoma for the evaluation of novel therapeutic strategies DOI Creative Commons
Alexander F. Haddad, Jacob S. Young, Dominic Amara

et al.

Neuro-Oncology Advances, Journal Year: 2021, Volume and Issue: 3(1)

Published: Jan. 1, 2021

Abstract Glioblastoma (GBM) is an incurable brain tumor with a median survival of approximately 15 months despite aggressive standard care that includes surgery, chemotherapy, and ionizing radiation. Mouse models have advanced our understanding GBM biology the development novel therapeutic strategies for patients. However, model selection crucial when testing developmental therapeutics, each mouse has unique advantages disadvantages can influence validity translatability experimental results. To shed light on this process, we discuss strengths limitations 3 types in review: syngeneic models, genetically engineered xenograft including traditional cell lines patient-derived models.

Language: Английский

Citations

129
Glioblastoma: An Update in Pathology, Molecular Mechanisms and Biomarkers DOI Open Access
Zhong Lan, Xin Li, Xiao-Qin Zhang

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(5), P. 3040 - 3040

Published: March 6, 2024

Glioblastoma multiforme (GBM) is the most common and malignant type of primary brain tumor in adults. Despite important advances understanding molecular pathogenesis biology this past decade, prognosis for GBM patients remains poor. characterized by aggressive biological behavior high degrees inter-tumor intra-tumor heterogeneity. Increased cellular heterogeneity may not only help more accurately define specific subgroups precise diagnosis but also lay groundwork successful implementation targeted therapy. Herein, we systematically review key achievements pathogenesis, mechanisms, biomarkers decade. We discuss pathology GBM, including genetics, epigenetics, transcriptomics, signaling pathways. that have potential clinical roles. Finally, new strategies, current challenges, future directions discovering therapeutic targets will be discussed.

Language: Английский

Citations

33
Exploring ncRNA-mediated regulation of EGFR signalling in glioblastoma: From mechanisms to therapeutics DOI
Riya Thapa, Muhammad Afzal, Ahsas Goyal

et al.

Life Sciences, Journal Year: 2024, Volume and Issue: 345, P. 122613 - 122613

Published: April 4, 2024

Language: Английский

Citations

26
Clustering Functional Magnetic Resonance Imaging Time Series in Glioblastoma Characterization: A Review of the Evolution, Applications, and Potentials DOI Creative Commons
Matteo De Simone, Giorgio İaconetta, Giuseppina Palermo

et al.

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(3), P. 296 - 296

Published: March 20, 2024

In this paper, we discuss how the clustering analysis technique can be applied to analyze functional magnetic resonance imaging (fMRI) time-series data in context of glioblastoma (GBM), a highly heterogeneous brain tumor. The precise characterization GBM is challenging and requires advanced analytical approaches. We have synthesized existing literature provide an overview algorithms help identify unique patterns within dynamics GBM. Our review shows that fMRI time series has great potential for improving differentiation between various subtypes GBM, which pivotal developing personalized therapeutic strategies. Moreover, method proves effective capturing temporal changes occurring enhancing monitoring disease progression response treatment. By thoroughly examining consolidating current research, paper contributes understanding techniques refine This article emphasizes importance incorporating cutting-edge into neuroimaging neuro-oncology research. providing detailed perspective, approach may guide future investigations boost development tailored strategies

Language: Английский

Citations

18
Dual and multi-targeted nanoparticles for site-specific brain drug delivery DOI
Yan Luo, Hang Yang, Yifan Zhou

et al.

Journal of Controlled Release, Journal Year: 2019, Volume and Issue: 317, P. 195 - 215

Published: Dec. 2, 2019

Language: Английский

Citations

99
Tumor Associated Macrophages, as the Dominant Immune Cells, Are an Indispensable Target for Immunologically Cold Tumor—Glioma Therapy? DOI Creative Commons
Ni Tong, Zhenqiang He, Yujie Ma

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2021, Volume and Issue: 9

Published: July 21, 2021

Tumor microenvironment (TME) is the cornerstone of occurrence, development, invasion and diffusion malignant central nerve system (CNS) tumor, glioma. As largest number inflammatory cells in glioma TME, tumor associated macrophages (TAMs) their secreted factors are indispensable to progression glioma, which a well-known immunologically “cold” including growth cells, invasion, migration, angiogenesis, cancer immunosuppression metabolism. TAMs intimately interface with treatment failure poor prognosis patients, density increases increasing grade. Recently, great progress has been made TAM-targeting for anti-tumor therapy. According TAMs’ function tumorigenesis progression, major strategies targeting hinder macrophage recruitment reduce viability or remodel phenotype from M2 M1. Different approaches offer unique effective effect by regulating phagocytosis, polarization pro-tumor behaviors therapy The present review summarizes significant characteristics related mechanisms addresses research on

Language: Английский

Citations

62
Ferroptosis: A New Road towards Cancer Management DOI Creative Commons
Iqra Bano, Pavel Horký, Syed Qamar Abbas

et al.

Molecules, Journal Year: 2022, Volume and Issue: 27(7), P. 2129 - 2129

Published: March 25, 2022

Ferroptosis is a recently described programmed cell death mechanism that characterized by the buildup of iron (Fe)-dependent lipid peroxides in cells and morphologically, biochemically, genetically distinct from other forms death, having emerged to play an important role cancer biology. has significant importance during treatment because combination factors, including suppression glutathione peroxidase 4 (Gpx4), cysteine deficiency, arachidonoyl (AA) peroxidation, which cause undergo ferroptosis. However, physiological significance ferroptosis throughout development still not fully understood. This current review focused on factors molecular mechanisms with diagrammatic illustrations have initiation sensitivity various malignancies. knowledge will open new road for research oncology management.

Language: Английский

Citations

49
Single-Cell Transcriptomics Revealed Subtype-Specific Tumor Immune Microenvironments in Human Glioblastomas DOI Creative Commons
Yong Xiao, Zhen Wang, Mengjie Zhao

et al.

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: May 20, 2022

Human glioblastoma (GBM), the most aggressive brain tumor, comprises six major subtypes of malignant cells, giving rise to both inter-patient and intra-tumor heterogeneity. The interaction between different tumor non-malignant cells collectively shape a microenvironment has not been systematically characterized. Herein, we sampled cellular milieu surgically resected primary tumors from 7 GBM patients using single-cell transcriptome sequencing. A lineage relationship analysis revealed that neural-progenitor-2-like (NPC2-like) state with high metabolic activity was associated origin. Mesenchymal-1-like (MES1-like) mesenchymal-2-like (MES2-like) correlated strongly immune infiltration chronic hypoxia niche responses. We identified four subsets tumor-associated macrophages/microglia (TAMs), among which TAM-1 co-opted acute hypoxia-response signatures, implicated in angiogenesis, invasion, poor prognosis. MES-like expressed highest number M2-promoting ligands compared other states while all were TAM M2-type polarization immunosuppression via set 10 ligand–receptor signaling pathways. Our results provide new insights into differential roles cell may be deployed for patient stratification personalized treatment.

Language: Английский

Citations

43
Liquid Biopsy in Glioblastoma DOI Open Access

Lorian Ronvaux,

Mattéo Riva, An Coosemans

et al.

Cancers, Journal Year: 2022, Volume and Issue: 14(14), P. 3394 - 3394

Published: July 13, 2022

Glioblastoma (GBM) is the most common and aggressive primary brain tumor. Despite recent advances in therapy modalities, overall survival of GBM patients remains poor. diagnosis relies on neuroimaging techniques. However, confirmation via histopathological molecular analysis necessary. Given intrinsic limitations such techniques, liquid biopsy (mainly blood samples) emerged as a non-invasive easy-to-implement alternative that could aid both follow-up patients. Cancer cells release tumoral content into bloodstream, circulating tumor DNA, microRNAs, cells, extracellular vesicles, or nucleosomes: all these serve marker GBM. In this narrative review, we discuss current knowledge, advantages, disadvantages each biomarker so far proposed.

Language: Английский

Citations

43