Potential Uses of Olive Oil Secoiridoids for the Prevention and Treatment of Cancer: A Narrative Review of Preclinical Studies

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(3), P. 1234 - 1234

Published: Jan. 27, 2021

The Mediterranean diet (MD) is a combination of foods mainly rich in antioxidants and anti-inflammatory nutrients that have been shown to many health-enhancing effects. Extra-virgin olive oil (EVOO) an important component the MD. importance EVOO can be attributed phenolic compounds, represented by alcohols, hydroxytyrosol, tyrosol, secoiridoids, which include oleocanthal, oleacein, oleuropein, ligstroside (along with aglycone glycosidic derivatives latter two). Each secoiridoid has studied characterized, their effects on human health documented several studies. Secoiridoids antioxidant, anti-inflammatory, anti-proliferative properties and, therefore, exhibit anti-cancer activity. This review summarizes most recent findings regarding pharmacological properties, molecular targets, action mechanisms focusing attention preventive activities. It provides critical analysis preclinical, vitro vivo, studies these natural bioactive compounds used as agents against various cancers. prospects for possible use cancer prevention treatment also discussed.

Language: Английский

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Valorizing the usage of olive leaves, bioactive compounds, biological activities, and food applications: A comprehensive review

Frontiers in Nutrition, Journal Year: 2022, Volume and Issue: 9

Published: Nov. 8, 2022

Olive oil production is a significant source of economic profit for Mediterranean nations, accounting around 98 percent global output. usage has increased dramatically in recent years, owing to its organoleptic characteristics and rising knowledge health advantages. The culture olive trees the manufacture industrial table produces enormous volumes solid waste dark liquid effluents, involving leaves, pomace, mill wastewaters. These by-products cause an issue manufacturers pose major environmental concerns. As result, partial reuse, like other agronomical wastes, goal be achieved. Because these are high bioactive chemicals, which, if isolated, might denote components with added value food, cosmetic, nutraceutical sectors, indeed, they include amounts beneficial organic acids, carbohydrates, proteins, fibers, phenolic materials, which distributed differently between various wastes depending on method techniques. However, extraction recovery materials from chosen problem their reasonable value, rigorous detection quantification required. primary aims this review context outline vital chemicals by-products, evaluate main developments extraction, purification, identification, study uses food packaging systems safety problems.

Language: Английский

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Influence of Olive Oil and Its Components on Breast Cancer: Molecular Mechanisms

Molecules, Journal Year: 2022, Volume and Issue: 27(2), P. 477 - 477

Published: Jan. 12, 2022

Breast cancer is the most frequent malignant neoplasia and a leading cause of mortality in women worldwide. The Mediterranean diet has been proposed as healthy dietary pattern with protective effects several chronic diseases, including breast cancer. This characterized by consumption abundant plant foods olive oil principal source fat, which considered one main components potential antioxidant, anti-inflammatory anticancer effects. Extra-virgin (EVOO) bioactive compounds, mainly monounsaturated fatty acids, triterpenes polyphenols, such phenolic alcohols (e.g., hydroxytyrosol), secoiridoids oleuropein oleocanthal), lignans pinoresinol) or flavonoids luteolin). While epidemiological evidence still limited, experimental vivo vitro data have shown effect this its compounds on mammary carcinogenesis. Such account through complex multiple mechanisms, changes epigenetics, transcriptome protein expression that modulate signaling pathways. Molecular targets EVOO role acquisition hallmarks. Although further research needed to elucidate their beneficial human prevention progression disease, points context heathy choice, while may be promising adjuvants strategies.

Language: Английский

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Olive byproducts and their bioactive compounds as a valuable source for food packaging applications

Comprehensive Reviews in Food Science and Food Safety, Journal Year: 2022, Volume and Issue: 21(2), P. 1218 - 1253

Published: Jan. 24, 2022

Abstract Among the most important agro‐industrial activities in Mediterranean basin, olive oil production has a high impact on economy of many countries. However, extraction generates huge quantities byproducts, including leaves, pomace residues, stones and wastewater, which have severe environmental impacts mainly because their phytotoxicity great organic content. Olive byproducts are regarded as inexpensive abundant raw materials rich bioactive compounds with varied health‐related activities. Several phenolic terpenoids were recovered from using different conventional advanced methods due to potential be used food, packaging, pharmaceutical, cosmetic industries. Recently, use functional enhance properties packaging systems was investigated sustainable strategy for food preservation, fostering sustainability olive‐oil chain, promoting circular economy. In this framework, main goals review summarize advancements extraction, purification, characterization, finally discuss applications well safety‐related aspects.

Language: Английский

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Therapeutic Properties and Use of Extra Virgin Olive Oil in Clinical Nutrition: A Narrative Review and Literature Update

Nutrients, Journal Year: 2022, Volume and Issue: 14(7), P. 1440 - 1440

Published: March 31, 2022

Extra virgin olive oil (EVOO) is a cornerstone of the Mediterranean diet (MedD). In this narrative review, we synthesize and illustrate various characteristics clinical applications EVOO its components—such as oleic acid, hydroxytyrosol, oleuropein—in field nutrition dietetics. The evidence split into therapy, acid-based enteral formulations oral supplementation formulations, parenteral nutrition, nutraceutical minor components EVOO. has diverse beneficial health properties, current supports use whole in therapy to improve cardiovascular health, lipoprotein metabolism, diabetes mellitus nutrition. Nevertheless, more intervention studies humans are needed chisel specific recommendations for therapeutic through different other diseases populations.

Language: Английский

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Anti-tumor Activity and Epigenetic Impact of the Polyphenol Oleacein in Multiple Myeloma

Cancers, Journal Year: 2019, Volume and Issue: 11(7), P. 990 - 990

Published: July 16, 2019

Olive oil contains different biologically active polyphenols, among which oleacein, the most abundant secoiridoid, has recently emerged for its beneficial properties in various disease contexts. By using vitro models of human multiple myeloma (MM), we here investigated anti-tumor potential oleacein and underlying bio-molecular sequelae. Within a low micromolar range, reduced viability MM primary samples cell lines even presence bone marrow stromal cells (BMSCs), while sparing healthy peripheral blood mononuclear cells. We also demonstrated that inhibited clonogenicity, prompted cycle blockade triggered apoptosis. evaluated epigenetic impact on cells, observed dose-dependent accumulation both acetylated histones α-tubulin, along with down-regulation several class I/II histone deacetylases (HDACs) at mRNA protein level, providing evidence HDAC inhibitory activity this compound; conversely, no effect global DNA methylation was found. Mechanistically, HDACs inhibition by associated Sp1, major transactivator promoter, via Caspase 8 activation. Of translational significance, synergistically enhanced anti-MM proteasome inhibitor carfilzomib. Altogether, these results indicate is endowed properties, associate significant as single agent or combination These findings may pave way to novel epi-therapeutic approaches based natural agents.

Language: Английский

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The Double-Edged Sword of Oleuropein in Ovarian Cancer Cells: From Antioxidant Functions to Cytotoxic Effects

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(1), P. 842 - 842

Published: Jan. 3, 2023

Oleuropein plays a key role as pro-oxidant well an antioxidant in cancer. In this study, the activity of oleuropein, vitro model ovarian (OCCs) and breast cancer cells (BCCs) was investigated. Cell viability cell death were analyzed. Oxidative stress measured by CM-H2DCFDA flow cytometry assay. Mitochondrial dysfunction evaluated based on mitochondrial reactive oxygen species (ROS) GPX4 protein levels. Further, effects iron metabolism analyzed measuring intracellular labile pool (LIP). We confirmed that high doses oleuropein show anti-proliferative pro-apoptotic HEY MCF-7 cells. Moreover, our results indicate low impair without affecting mortality cells, also decrease LIP ROS levels, keeping them unchanged For first time, data reduce erastin-mediated death. Interestingly, decreases levels OCCs treated with erastin. Noteworthily, we observed increased amount scavenging enzyme together consistent reduction ROS, confirming oxidative model.

Language: Английский

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Polyphenol-Rich Extracts from Agroindustrial Waste and Byproducts: Results and Perspectives According to the Green Chemistry and Circular Economy

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(23), P. 12871 - 12895

Published: June 3, 2024

Polyphenols are natural secondary metabolites found in plants endowed with multiple biological activities (antioxidant, anti-inflammatory, antimicrobial, cardioprotective, and anticancer). In view of these properties, they find many applications used as active ingredients nutraceutical, food, pharmaceutical, cosmetic formulations. accordance green chemistry circular economy strategies, can also be recovered from agroindustrial waste reused various sectors, promoting sustainable processes. This review described structural characteristics, methods for extraction, polyphenolic extracts obtained two selected plant materials the Mediterranean area olive (Olea europaea L.) pomegranate (Punica granatum based on recent literature, highlighting future research perspectives.

Language: Английский

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Antioxidant Extracts from Greek and Spanish Olive Leaves: Antimicrobial, Anticancer and Antiangiogenic Effects

Antioxidants, Journal Year: 2024, Volume and Issue: 13(7), P. 774 - 774

Published: June 27, 2024

L. is the most valuable species of

Language: Английский

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Olive leaf extract impairs mitochondria by pro-oxidant activity in MDA-MB-231 and OVCAR-3 cancer cells

Biomedicine & Pharmacotherapy, Journal Year: 2020, Volume and Issue: 134, P. 111139 - 111139

Published: Dec. 24, 2020

Breast and ovarian cancers are the leading fifth reason for tumor death among females, respectively. Recently, many studies demonstrated antiproliferative activities of natural aliments in cancer. In this study, we investigated antitumor potential Olive Leaf Extract (OLE) triple-negative breast cancer cells. A HPLC/DAD analysis on OLE has been performed to assess total polyphenolics other secondary metabolites content. HCEpiC, MDA-MB-231, OVCAR-3 cell lines were used. MTS, Cytofluorimetric, Western Blot analyze viability, proliferation, apoptosis, oxidative stress. Fluorimetric IncuCyte® analyses carried out evaluate apoptosis mitochondrial function. We confirmed that OLE, containing a quantity oleuropein 87 % extract, shows anti-proliferative pro-apoptotic activity MDA-MB-231 For first time, our results indicate inhibits viability inducing cycle arrest, it also increases apoptotic up-regulating protein level cleaved-PARP caspase 9. Moreover, data show treatment causes significant decrease functionality, paralleled by reduction membrane potential. Interestingly, increased intracellular reactive oxygen species (ROS) together with decreased ROS scavenging enzymes, confirming stress both models. Our demonstrate generation represented primary mechanism activity, as pretreatment antioxidant N-acetylcysteine prevented OLE-induced arrest apoptosis.

Language: Английский

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