Cancers,
Journal Year:
2023,
Volume and Issue:
15(8), P. 2195 - 2195
Published: April 7, 2023
Metabolic
changes
are
an
important
component
of
tumor
cell
progression.
Tumor
cells
adapt
to
environmental
stresses
via
carbohydrate
and
lipid
metabolism.
Autophagy,
a
physiological
process
in
mammalian
that
digests
damaged
organelles
misfolded
proteins
lysosomal
degradation,
is
closely
associated
with
metabolism
cells,
acting
as
meter
cellular
ATP
levels.
In
this
review,
we
discuss
the
glycolytic
biosynthetic
pathways
their
impact
on
carcinogenesis
autophagy
pathway.
addition,
these
metabolic
lung
cancer.
Frontiers in Pharmacology,
Journal Year:
2023,
Volume and Issue:
14
Published: April 19, 2023
Breast
cancer
(BC)
is
the
most
common
malignancy
among
women
worldwide.
Like
many
other
cancers,
BC
therapy
challenging
and
sometimes
frustrating.
In
spite
of
various
therapeutic
modalities
applied
to
treat
cancer,
drug
resistance,
also
known
as,
chemoresistance,
very
in
almost
all
BCs.
Undesirably,
a
breast
tumor
might
be
resistant
different
curative
approaches
(e.g.,
chemo-
immunotherapy)
at
same
period
time.
Exosomes,
as
double
membrane-bound
extracellular
vesicles
1)
secreted
from
cell
species,
can
considerably
transfer
products
components
through
bloodstream.
this
context,
non-coding
RNAs
(ncRNAs),
including
miRNAs,
long
ncRNAs
(lncRNAs),
circular
(circRNAs),
are
chief
group
exosomal
constituents
with
amazing
abilities
regulate
underlying
pathogenic
mechanisms
BC,
such
proliferation,
angiogenesis,
invasion,
metastasis,
migration,
particularly
resistance.
Thereby,
considered
potential
mediators
progression
Moreover,
corresponding
circulate
bloodstream
found
body
fluids,
they
serve
foremost
prognostic/diagnostic
biomarkers.
The
current
study
aims
comprehensively
review
recent
findings
on
BC-related
molecular
signaling
pathways
affected
by
lncRNAs,
circRNAs,
focus
Also,
diagnosis
prognosis
will
discussed
detail.
Journal of Advanced Research,
Journal Year:
2023,
Volume and Issue:
55, P. 103 - 118
Published: March 4, 2023
Cancer
management
faces
multiple
obstacles,
including
resistance
to
current
therapeutic
approaches.
In
the
face
of
challenging
microenvironments,
cancer
cells
adapt
metabolically
maintain
their
supply
energy
and
precursor
molecules
for
biosynthesis
thus
sustain
rapid
proliferation
tumor
growth.
Among
various
metabolic
adaptations
observed
in
cells,
altered
glucose
metabolism
is
most
widely
studied.
The
aberrant
glycolytic
modification
has
been
associated
with
cell
division,
growth,
progression,
drug
resistance.
higher
rates
glycolysis
as
a
hallmark
modulated
by
transcription
factor
hypoxia
inducible
1
alpha
(HIF-1α),
downstream
target
PI3K/Akt
signaling,
deregulated
pathway
cancer.
We
provide
detailed
overview
current,
primarily
experimental,
evidence
on
potential
effectiveness
flavonoids
combat
glycolysis-induced
conventional
targeted
therapies.
manuscript
focuses
reducing
via
affecting
PI3K/Akt,
HIF-1α
(as
critical
that
regulated
pathway),
key
mediators
PI3K/Akt/HIF-1α
signaling
(glucose
transporters
enzymes).
working
hypothesis
proposes
–
an
attractive
application
mitigate
Phytochemicals
represent
source
promising
substances
applicable
primary,
secondary,
tertiary
care.
However,
accurate
patient
stratification
individualized
profiling
crucial
steps
paradigm
shift
from
reactive
predictive,
preventive,
personalized
medicine
(PPPM
/
3PM).
article
focused
targeting
molecular
patterns
natural
provides
evidence-based
recommendations
3PM
relevant
implementation.
Frontiers in Pharmacology,
Journal Year:
2023,
Volume and Issue:
14
Published: Oct. 17, 2023
Lactate
dehydrogenase
(LDH)
is
a
crucial
enzyme
involved
in
energy
metabolism
and
present
various
cells
throughout
the
body.
Its
diverse
physiological
functions
encompass
glycolysis,
its
abnormal
activity
associated
with
numerous
diseases.
Targeting
LDH
has
emerged
as
vital
approach
drug
discovery,
leading
to
identification
of
inhibitors
among
natural
compounds,
such
polyphenols,
alkaloids,
terpenoids.
These
compounds
demonstrate
therapeutic
potential
against
LDH-related
diseases,
including
anti-cancer
effects.
However,
challenges
concerning
limited
bioavailability,
poor
solubility,
toxicity
must
be
addressed.
Combining
led
promising
outcomes
preclinical
studies.
This
review
highlights
promise
for
treating
cancer,
cardiovascular,
neurodegenerative
