Hidden in Plants—A Review of the Anticancer Potential of the Solanaceae Family in In Vitro and In Vivo Studies DOI Open Access
Tomasz Kowalczyk, Anna Merecz-Sadowska, Patrícia Rijo

et al.

Cancers, Journal Year: 2022, Volume and Issue: 14(6), P. 1455 - 1455

Published: March 11, 2022

Many of the anticancer agents that are currently in use demonstrate severe side effects and encounter increasing resistance from target cancer cells. Thus, despite significant advances therapy recent decades, there is still a need to discover develop new, alternative agents. The plant kingdom contains range phytochemicals play important roles prevention treatment many diseases. Solanaceae family widely used various diseases, including cancer, due its bioactive ingredient content. purpose this literature review highlight antitumour activity extracts-single isolated compounds nanoparticles with extracts-and their synergistic effect chemotherapeutic vitro vivo models. In addition, biological properties plants have not yet been investigated, which represents challenge an opportunity for future therapy.

Language: Английский

Carbon-Based Fluorescent Nano-Biosensors for the Detection of Cell-Free Circulating MicroRNAs DOI Creative Commons

Pooja Ratre,

Nazim Nazeer, Roshani Kumari

et al.

Biosensors, Journal Year: 2023, Volume and Issue: 13(2), P. 226 - 226

Published: Feb. 4, 2023

Currently, non-communicable diseases (NCDs) have emerged as potential risks for humans due to adopting a sedentary lifestyle and inaccurate diagnoses. The early detection of NCDs using point-of-care technologies significantly decreases the burden will be poised transform clinical intervention healthcare provision. An imbalance in levels circulating cell-free microRNAs (ccf-miRNA) has manifested NCDs, which are passively released into bloodstream or actively produced from cells, improving efficacy disease screening providing enormous sensing potential. effective ccf-miRNA continues significant technical challenge, even though sophisticated equipment is needed analyze readouts expression patterns. Nanomaterials come light solution they provide advantages over other widely used diagnostic techniques measure miRNAs. Particularly, CNDs-based fluorescence nano-biosensors great interest. Owing excellent characteristics CNDs, developing such sensors ccf-microRNAs been much more accessible. Here, we critically examined recent advancements fluorescence-based CNDs biosensors, including tools manufacturing these biosensors. Green synthesis methods scaling up high-quality, fluorescent natural source discussed. various surface modifications that help attach biomolecules utilizing covalent conjugation multiple applications, self-assembly, sensing, imaging, analyzed. current review particular interest researchers interested materials chemistry, nanomedicine, related fields, focus on ccf-miRNAs applications medical field.

Language: Английский

Citations

27
MicroRNA Dysregulation in Early Breast Cancer Diagnosis: A Systematic Review and Meta-Analysis DOI Open Access

Alejandro Garrido-Palacios,

Ana María Rojas-Carvajal, Ana María Núñez-Negrillo

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(9), P. 8270 - 8270

Published: May 5, 2023

Breast cancer continues to be the leading cause of death in women worldwide. Mammography, which is current gold standard technique used diagnose it, presents strong limitations early ages where breast much more aggressive and fatal. MiRNAs present numerous body fluids might represent a new line research biomarkers, especially oncomiRNAs, known play an important role suppression development neoplasms. The aim this systematic review meta-analysis was evaluate dysregulated miRNA biomarkers their diagnostic accuracy cancer. Two independent researchers reviewed included studies according preferred reporting items for reviews meta-analyses (PRISMA) guidelines. A protocol registered PROSPERO with registration number “CRD42021256338”. Observational case-control-based analyzing concentrations microRNAs have been published within last 10 years were selected, miRNAs healthy controls analyzed. Random-effects miR-155 performed on provided enough data calculate odds ratios. We determined that 34 substantially could considered Individually, better results than mammography average. However, when several are screen, forming panel, sensitivity specificity rates improve, they can associated classic such us CA-125 or CEA. Based our meta-analysis, promising biomarker patient population.

Language: Английский

Citations

24
Melodic maestros: Unraveling the role of miRNAs in the diagnosis, progression, and drug resistance of malignant pleural mesothelioma DOI

Mai A. Abd‐Elmawla,

Sherif S. Abdel Mageed, Tohada M. AL‐Noshokaty

et al.

Pathology - Research and Practice, Journal Year: 2023, Volume and Issue: 250, P. 154817 - 154817

Published: Sept. 13, 2023

Language: Английский

Citations

24
Liquid Biopsy in the Clinical Management of Cancers DOI Open Access

Ho-Yin Ho,

Kei-See Chung,

Chau-Ming Kan

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(16), P. 8594 - 8594

Published: Aug. 6, 2024

Liquid biopsy, a noninvasive diagnosis that examines circulating tumor components in body fluids, is increasingly used cancer management. An overview of relevant literature emphasizes the current state liquid biopsy applications care. Biomarkers particularly DNA (ctDNA), RNAs (ctRNA), cells (CTCs), extracellular vesicles (EVs), and other components, offer promising opportunities for early diagnosis, treatment selection, monitoring, disease assessment. The implementation precision medicine has shown significant potential various types, including lung cancer, colorectal breast prostate cancer. Advances genomic molecular technologies such as next-generation sequencing (NGS) digital polymerase chain reaction (dPCR) have expanded utility enabling detection somatic variants actionable alterations tumors. also demonstrated predicting responses, monitoring minimal residual (MRD), assessing heterogeneity. Nevertheless, standardizing techniques, interpreting results, integrating them into clinical routine remain challenges. Despite these challenges, implications management, offering dynamic approach to understanding biology guiding personalized strategies.

Language: Английский

Citations

9
Comprehensive insights into pathogenicity and emerging CRISPR-integrated biosensors for the early detection of breast cancer biomarkers DOI

Ashok Saini,

Neeraj Dilbaghi, Neelam Yadav

et al.

Microchemical Journal, Journal Year: 2025, Volume and Issue: unknown, P. 112908 - 112908

Published: Jan. 1, 2025

Language: Английский

Citations

1
Exploring Biomarkers for Malaria: Advances in Early Detection and Asymptomatic Diagnosis DOI Creative Commons

Jacko Abiwaqash Harmonis,

Sri Agung Fitri Kusuma, Yaya Rukayadi

et al.

Biosensors, Journal Year: 2025, Volume and Issue: 15(2), P. 106 - 106

Published: Feb. 12, 2025

Malaria is a tropical disease caused by the Plasmodium parasite, which was responsible for 249 million cases worldwide in 2022. currently diagnosed using RDTs, PCR-based methods, or blood smear microscopy. Ideal biomarkers have been identified malaria, with potential improving treatment, diagnosis, and overall clinical outcomes. This review discusses types of existing opportunities new to be used as diagnostic components detecting Plasmodium, including terms sensitivity, detection limit, specificity, species that can detected. Following comparison, five main ideal malaria were identified, namely HRP2, pLDH, hemozoin, aldolase, pGDH. These distinguished themselves markedly from others specificity detection, sensitivity analysis, use non-invasive samples. Several other biomarkers, such CRP, Ang-1, Ang-2, PCT, show their ability differentiate severity, levels these determined body comparison parasitemia. Of hemozoin aldolase still developed regarding samples different species. Further research on PCT needed evaluate potential.

Language: Английский

Citations

1
Systems epigenetic approach towards non-invasive breast cancer detection DOI Creative Commons
Chiara Herzog,

Bente Theeuwes,

Allison Jones

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 2, 2025

Language: Английский

Citations

1
Electroanalytical overview: screen-printed electrochemical sensing platforms for the detection of vital cardiac, cancer and inflammatory biomarkers DOI Creative Commons
Robert D. Crapnell, Alejandro García‐Miranda Ferrari, Nina Dempsey‐Hibbert

et al.

Sensors & Diagnostics, Journal Year: 2022, Volume and Issue: 1(3), P. 405 - 428

Published: Jan. 1, 2022

Herein we review the use of electrochemical point-of-care SPE-based sensor technologies towards detection vital, established biomarkers related to cardiac injury, cancer diagnostics and acute inflammatory conditions.

Language: Английский

Citations

31
Advances of Epigenetic Biomarkers and Epigenome Editing for Early Diagnosis in Breast Cancer DOI Open Access
Pourya Sarvari, Pouya Sarvari, Ivonne Ramírez‐Díaz

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(17), P. 9521 - 9521

Published: Aug. 23, 2022

Epigenetic modifications are known to regulate cell phenotype during cancer progression, including breast cancer. Unlike genetic alterations, changes in the epigenome reversible, thus potentially reversed by epi-drugs. Breast cancer, most common cause of death worldwide women, encompasses multiple histopathological and molecular subtypes. Several lines evidence demonstrated distortion epigenetic landscape Interestingly, mammary cells isolated from patients cultured ex vivo maintained tumorigenic exhibited aberrant modifications. Recent studies indicated that therapeutic efficiency for regimens has increased over time, resulting reduced mortality. Future medical treatment patients, however, will likely depend upon a better understanding The present review aims outline different mechanisms DNA methylation, histone modifications, ncRNAs with their impact on as well discuss highlighting central role pathogenesis. We propose new research areas may facilitate locus-specific editing therapeutics.

Language: Английский

Citations

31
Extracellular Vesicles in Breast Cancer: From Biology and Function to Clinical Diagnosis and Therapeutic Management DOI Open Access
Sylvain Loric, Jérôme Alexandre Denis, Cédric Desbène

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(8), P. 7208 - 7208

Published: April 13, 2023

Breast cancer (BC) is the first worldwide most frequent in both sexes and commonly diagnosed females. Although BC mortality has been thoroughly declining over past decades, there are still considerable differences between women with early when metastatic diagnosed. treatment choice widely dependent on precise histological molecular characterization. However, recurrence or distant metastasis occurs even recent efficient therapies. Thus, a better understanding of different factors underlying tumor escape mainly mandatory. Among leading candidates continuous interplay cells their microenvironment, where extracellular vesicles play significant role. vesicles, smaller ones, also called exosomes, can carry biomolecules, such as lipids, proteins, nucleic acids, generate signal transmission through an intercellular transfer content. This mechanism allows to recruit modify adjacent systemic microenvironment support further invasion dissemination. By reciprocity, stromal use exosomes profoundly cell behavior. review intends cover literature role vesicle production normal cancerous breast tissues. Specific attention paid for diagnosis, follow-up, prognosis because actually under spotlight researchers high-potential source liquid biopsies. Extracellular new targets therapy nanovectors drive drug delivery summarized.

Language: Английский

Citations

19