Exploring the dynamic interplay between cancer stem cells and the tumor microenvironment: implications for novel therapeutic strategies

Journal of Translational Medicine, Journal Year: 2023, Volume and Issue: 21(1)

Published: Oct. 2, 2023

Cancer stem cells (CSCs) have emerged as key contributors to tumor initiation, growth, and metastasis. In addition, CSCs play a significant role in inducing immune evasion, thereby compromising the effectiveness of cancer treatments. The reciprocal communication between microenvironment (TME) is observed, with TME providing supportive niche for CSC survival self-renewal, while CSCs, turn, influence polarization persistence TME, promoting an immunosuppressive state. Consequently, these interactions hinder efficacy current therapies, necessitating exploration novel therapeutic approaches modulate target CSCs. this review, we highlight intricate strategies employed by evade surveillance develop resistance therapies. Furthermore, examine dynamic interplay shedding light on how interaction impacts progression. Moreover, provide overview advanced that specifically which hold promise future clinical translational studies treatment.

Language: Английский

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Cancer metastasis: Molecular mechanisms and clinical perspectives

Pharmacology & Therapeutics, Journal Year: 2023, Volume and Issue: 250, P. 108522 - 108522

Published: Sept. 1, 2023

Language: Английский

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Targeting Cancer Stem Cells as the Key Driver of Carcinogenesis and Therapeutic Resistance

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(2), P. 1786 - 1786

Published: Jan. 16, 2023

The emerging concept of cancer stem cells (CSCs) as the key driver behind carcinogenesis, progression, and diversity has displaced prior model a tumor composed with similar subsequently acquired mutations an equivalent capacity for renewal, invasion, metastasis. This significant change shifted research focus toward targeting CSCs to eradicate cancer. may be characterized using cell surface markers. They are defined by their self-renew differentiate, resist conventional therapies, generate new tumors following repeated transplantation in xenografted mice. CSCs' functional capabilities governed various intracellular extracellular variables such pluripotency-related transcription factors, internal signaling pathways, external stimuli. Numerous natural compounds synthetic chemicals have been investigated ability disrupt these regulatory components inhibit stemness terminal differentiation CSCs, hence achieving clinical implications. However, no treatment focuses on biological consequences drugs functions established. article provides biomedical discussion at time along overview origin, features, characterization, isolation techniques, novel targeted therapeutic approaches. Additionally, we highlighted factors endorsed controlling or helping promote CSCs. Our objective was encourage future studies prospective treatments develop framework application single combined therapeutics forms

Language: Английский

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Natural Compounds and Breast Cancer: Chemo-Preventive and Therapeutic Capabilities of Chlorogenic Acid and Cinnamaldehyde

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(3), P. 361 - 361

Published: March 11, 2024

Globally, breast cancer is not only the most frequently diagnosed but also leading cause of death in women. Depending on histotype, conventional treatment options vary greatly efficacy and accompanying side effects. Thus, there a need for more effective safer strategies that impact at all stages. Plant-based natural products are easily available, with them proving inexpensive. Two such phytochemicals chlorogenic acid cinnamaldehyde. Studies have shown their against different molecular subtypes cancers vitro vivo. In this review, we discuss current status anticancer research specific emphasis We describe multiple mechanisms action destroying cells, potential uses, translational applications. include future directions investigations to progress cinnamaldehyde from bench bedside.

Language: Английский

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Intricate relationship between cancer stemness, metastasis, and drug resistance

MedComm, Journal Year: 2024, Volume and Issue: 5(10)

Published: Sept. 21, 2024

Cancer stem cells (CSCs) are widely acknowledged as the drivers of tumor initiation, epithelial-mesenchymal transition (EMT) progression, and metastasis. Originating from both hematologic solid malignancies, CSCs exhibit quiescence, pluripotency, self-renewal akin to normal cells, thus orchestrating heterogeneity growth. Through a dynamic interplay with microenvironment (TME) intricate signaling cascades, undergo transitions differentiated cancer culminating in therapy resistance disease recurrence. This review undertakes an in-depth analysis multifaceted mechanisms underlying stemness CSC-mediated therapy. Intrinsic factors encompassing TME, hypoxic conditions, oxidative stress, alongside extrinsic processes such drug efflux mechanisms, collectively contribute therapeutic resistance. An exploration into key pathways, including JAK/STAT, WNT, NOTCH, HEDGEHOG, sheds light on their pivotal roles sustaining phenotypes. Insights gleaned preclinical clinical studies hold promise refining discovery efforts optimizing interventions, especially chimeric antigen receptor (CAR)-T cell therapy, cytokine-induced killer (CIK) natural (NK) cell-mediated CSC-targeting others. Ultimately use sorting single sequencing approaches for elucidating fundamental characteristics inherent will enhance our comprehension CSC intratumor heterogeneity, which ultimately would inform about tailored personalized interventions.

Language: Английский

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Peptide-functionalized gold nanostars-assisted single-cell Raman spectra for molecular analysis of tumor metastasis based on cancer stem cells

Talanta, Journal Year: 2025, Volume and Issue: 286, P. 127525 - 127525

Published: Jan. 7, 2025

Language: Английский

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Cancer Stem Cell Regulation as a Target of Therapeutic Intervention: Insights into Breast, Cervical and Lung Cancer

Cell Biochemistry and Biophysics, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

Language: Английский

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Mechanism of action of genistein on breast cancer and differential effects of different age stages

Pharmaceutical Biology, Journal Year: 2025, Volume and Issue: 63(1), P. 141 - 155

Published: Feb. 25, 2025

Context Genistein, a soy-derived isoflavone, exhibits structural similarities with 17β-estradiol and demonstrates antioxidant, anti-inflammatory, estrogenic properties. Despite its low bioavailability limiting clinical application, it shows potential for breast cancer prevention treatment.

Language: Английский

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Focal Adhesion Kinase Fine Tunes Multifaced Signals toward Breast Cancer Progression

Cancers, Journal Year: 2021, Volume and Issue: 13(4), P. 645 - 645

Published: Feb. 5, 2021

Breast cancer represents the most common diagnosed malignancy and main leading cause of tumor-related death among women worldwide. Therefore, several efforts have been made in order to identify valuable molecular biomarkers for prognosis prediction therapeutic responses breast tumor patients. In this context, emerging discoveries indicated that focal adhesion kinase (FAK), a non-receptor tyrosine kinase, might represent promising target involved tumorigenesis. Of note, high FAK expression activity tightly correlated with poor clinical outcome metastatic features tumors, including cancer. Recently, role integrin-FAK signaling mechanotransduction has suggested function within microenvironment ascertained toward angiogenesis vascular permeability. also stem cells (CSCs)-mediated initiation, maintenance tumors. addition, potential elicit tumor-promoting effects even associated capability modulate immune responses. On basis these findings, agents targeting exploited diverse preclinical models. Here, we recapitulate multifaceted action exerted by its prognostic significance Moreover, highlight recent evidence regarding usefulness inhibitors treatment

Language: Английский

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The cell cycle‐related genes RHAMM, AURKA, TPX2, PLK1, and PLK4 are associated with the poor prognosis of breast cancer patients

Journal of Cellular Biochemistry, Journal Year: 2022, Volume and Issue: 123(3), P. 581 - 600

Published: Jan. 10, 2022

Abstract Breast cancer is the third most common type of diagnosed. Cell cycle a complex but highly organized and controlled process, in which normal cells sense mitogenic growth signals that instruct them to enter progress through their cell cycle. This process culminates division generating two daughter with identical amounts genetic material. Uncontrolled proliferation one hallmarks cancer. In this study, we analyzed expression cycle‐related genes receptor for hyaluronan (HA)‐mediated motility (RHAMM), AURKA, TPX2, PLK1, PLK4 correlated prognosis collective 3952 breast patients. A high messenger RNA all studied poor prognosis. Stratifying patients according hormonal receptors, found estrogen progesterone receptor‐positive human epithelial factor 2‐negative tumors, Luminal B five correlates worse survival. qPCR analysis panel lines representative major molecular subtypes indicated predominant luminal subtype. vitro experiments showed radiation influences both triple‐negative model lines. Functional MDA‐MB‐231 small interfering knockdown TPX2 pharmacological inhibition PLK1 had an impact on colony formation. Looking potential upstream regulation by microRNAs, observed differential RHAMM, after transfecting three different microRNAs. Survival miR‐34c‐5p, miR‐375, miR‐142‐3p Our study suggests can be used as targets treatment or prognostic value

Language: Английский

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