Archives of Pharmacal Research, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 3, 2024
Language: Английский
Biomolecules, Journal Year: 2021, Volume and Issue: 11(6), P. 894 - 894
Published: June 16, 2021
Chalcones (1,3-diaryl-2-propen-1-ones) are precursors for flavonoids and isoflavonoids, which common simple chemical scaffolds found in many naturally occurring compounds. Many chalcone derivatives were also prepared due to their convenient synthesis. as weandhetic analogues have attracted much interest broad biological activities with clinical potentials against various diseases, particularly antitumor activity. The family has demonstrated potential vitro vivo activity cancers via multiple mechanisms, including cell cycle disruption, autophagy regulation, apoptosis induction, immunomodulatory inflammatory mediators. It represents a promising strategy develop chalcones novel anticancer agents. In addition, the combination of other therapies is expected be an effective way improve therapeutic efficacy. However, despite encouraging results response observed studies, full description toxicity required use safe drugs treatment cancer. this review, we will summarize recent advances agents mechanisms action. Besides, future applications scope toward prevention cancer brought out.
Language: Английский
Citations
252
Plants, Journal Year: 2021, Volume and Issue: 10(12), P. 2751 - 2751
Published: Dec. 14, 2021
There are more than 30 species of Glycyrrhiza genus extensively spread worldwide. It was the most prescribed herb in Ancient Egyptian, Roman, Greek, East China, and West from Former Han era. various beneficial effects licorice root extracts, such as treating throat infections, tuberculosis, respiratory, liver diseases, antibacterial, anti-inflammatory, immunodeficiency. On other hand, traditional medicines getting attraction to treat many diseases. Therefore, it is vital screen medicinal plants find potential new compounds chronic diseases cardiovascular, anticancer, hepatoprotective, etc. This work comprehensively reviews ethnopharmacological uses, phytochemistry, biological activities, clinical evidence, toxicology licorice, which will serve a resource for future fundamental studies. An attempt has been made establish pharmacological effect different In addition, focus this review article on molecular mechanism extracts their four flavonoids (isoliquiritigenin, liquiritigenin, lichalocone, glabridin) pharmacologic activities. Licorice could be natural alternative current therapy exterminate emerging disorders with mild side effects. provide systematic insights into ancient drug further development use.
Language: Английский
Citations
205
Cancer Letters, Journal Year: 2024, Volume and Issue: 600, P. 217156 - 217156
Published: Aug. 8, 2024
Cancer cells display an altered metabolic phenotype, characterised by increased glycolysis and lactate production, even in the presence of sufficient oxygen - a phenomenon known as Warburg effect. This reprogramming is crucial adaptation that enables cancer to meet their elevated energy biosynthetic demands. Importantly, tumor microenvironment plays pivotal role shaping sustaining this shift cells. review explores intricate relationship between effect, highlighting how communication within niche regulates cell metabolism impacts progression therapeutic resistance. We discuss potential targeting effect promising strategy, with aim disrupting advantage enhancing our understanding complex interplay microenvironment.
Language: Английский
Citations
20
European Journal of Medicinal Chemistry, Journal Year: 2021, Volume and Issue: 229, P. 114062 - 114062
Published: Dec. 21, 2021
Language: Английский
Citations
76
Antioxidants, Journal Year: 2022, Volume and Issue: 11(7), P. 1349 - 1349
Published: July 11, 2022
Oxidative stress could lead to a variety of body dysfunctions, including neurodegeneration and cancer, which are closely associated with intracellular signal transducers such as reactive oxygen species (ROS). It has been suggested that ROS is the upstream regulator autophagy, it provides negative feedback regulation remove oxidative damage. Defects in ROS-autophagic redox homeostasis increased production accumulation damaged organelles turn promote metabolic reprogramming induce tumorigenesis. One significant characteristic pancreatic cancer cellular energy metabolism, facilitates rapid growth, invasiveness, survival cells. Thus, rectification dysfunction essential therapeutic targeting. Isoliquiritigenin (ISL) chalcone obtained from plant Glycyrrhiza glabra, powdered root licorice consumed for centuries different regions world. ISL known be natural antioxidant possesses diversified functions, This review contains discussions on herbal source, biological properties, anticancer potential ISL. first time activities elucidated, coverage involvement antioxidation, regulation, autophagy development. Furthermore, some remarks related compounds isoflavonoid biosynthetic pathway will also discussed.
Language: Английский
Citations
40
MedComm, Journal Year: 2023, Volume and Issue: 4(3)
Published: May 26, 2023
In the central nervous system diseases, glioma is one of most common malignancies around world. Despite recent improvements in therapies for glioma, prognosis some high-risk remains poor. isoliquiritigenin (ISL) reported to have antioxidative and antitumor activities. However, potential mechanisms between ISL circle RNAs (circRNAs) tumorigenesis process not yet been reported. Here, we treated cells with ISL, circRNA expression levels were detected. Circ0030018 was found significantly downregulated by ISL. Therefore, explored circ0030018 profiles functions finding that evidently overexpressed cell lines. Colony formation, CCK-8, transwell assay made clear silencing dramatically cut down growth invasion. Moreover, ROS level detected find silence remarkably enhanced oxidative stress glioma. Mechanism studies conducted investigate underlying basis function unveiling realized its partially through miR-1236/HER2 signaling conclusion, our study investigated roles on circ0030018/miR-1236/HER2 pathway progression. could act as prospective biologic signature or therapeutic target
Language: Английский
Citations
40
Journal of Ethnopharmacology, Journal Year: 2023, Volume and Issue: 318, P. 117059 - 117059
Published: Aug. 20, 2023
Language: Английский
Citations
34
Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14
Published: Sept. 20, 2023
Bazhen Decoction (BZD) is a common adjuvant therapy drug for colorectal cancer (CRC), although its anti-tumor mechanism unknown. This study aims to explore the core components, key targets, and potential mechanisms of BZD treatment CRC.The Traditional Chinese Medicine Systems Pharmacology (TCMSP) was employed acquire BZD's active ingredient targets. Meanwhile, Drugbank, Therapeutic Target Database (TTD), DisGeNET, GeneCards databases were used retrieve pertinent targets CRC. The Venn plot obtain intersection Cytoscape software construct an "herb-ingredient-target" network identify GO KEGG pathway enrichment analyses conducted using R language software. Molecular docking ingredients drugs accomplished PyMol Autodock Vina Cell animal research confirmed efficacy in treating cancer.BZD comprises 173 effective ingredients. Using four databases, 761 related CRC identified. yielded 98 which utilized network. effector components with most quercetin, kaempferol, licochalcone A, naringenin. Protein-protein interaction (PPI) analysis revealed that AKT1, MYC, CASP3, ESR1, EGFR, HIF-1A, VEGFR, JUN, INS, STAT3. findings from molecular suggest exhibits favorable binding target. Furthermore, demonstrates can modulate multiple signaling pathways CRC, like T cell receptor, PI3K-Akt, apoptosis, P53, VEGF pathway. In vitro, studies have shown dose-dependently inhibits colon growth invasion promotes apoptosis. Animal experiments reverse abnormal expression PI3K, AKT, STAT3, TP53 genes. also increases ratio CD4+ cells CD8+ spleen tumor tissues, boosting IFN-γ expression, essential immunity. has downregulate PD-1 on surfaces, indicating ability effectively restore function by inhibiting immune checkpoints. results HE staining safety profiles.BZD treats through metabolic pathways. genes such as TP53, suppresses progression regulating PI3K-AKT, VEGF. increase number promote activation tumor-bearing mice, enhancing against cancer. Among them, naringenin, formaronetin are more highly predictive mice. great significance development novel anti-cancer drugs. It highlights importance pharmacology-based approaches studying complex traditional medicine formulations.
Language: Английский
Citations
27
Journal of Xenobiotics, Journal Year: 2024, Volume and Issue: 14(4), P. 1541 - 1569
Published: Oct. 18, 2024
Plants are continuously exposed to environmental challenges, including pollutants, pesticides, and heavy metals, collectively termed xenobiotics. These substances induce oxidative stress by generating reactive oxygen species (ROS), which can damage cellular components such as lipids, proteins, nucleic acids. To counteract this, plants have evolved complex metabolic pathways detoxify process these harmful compounds. Oxidative in primarily arises from the overproduction of hydrogen peroxide (H2O2), superoxide anions (O2•−), singlet (1O2), hydroxyl radicals (•OH), by-products activities photosynthesis respiration. The presence xenobiotics leads a notable increase ROS, result disruption. combat developed strong antioxidant defense mechanism that includes enzymatic antioxidants work together eliminate thereby reducing their effects. In addition defenses, also synthesize various non-enzymatic antioxidants, flavonoids, phenolic acids, vitamins. compounds effectively neutralize ROS help regenerate other offering extensive protection against stress. metabolism xenobiotic occurs three stages: first involves modification, refers chemical alteration make them less harmful. second conjugation, where modified combined with solubility, facilitating elimination plant. third stage compartmentalization, is storage or isolation conjugated specific parts plant, helping prevent vital functions. Secondary metabolites found plants, alkaloids, terpenoids, play role detoxification Gaining deeper understanding mechanisms essential, this knowledge lead formulation plant-derived strategies aimed at alleviating effects pollution enhancing human health improving capabilities, discussed review.
Language: Английский
Citations
12
Drug Design Development and Therapy, Journal Year: 2024, Volume and Issue: Volume 18, P. 3233 - 3253
Published: July 1, 2024
Gastric cancer (GC) is a prevalent gastrointestinal tumor characterized by high mortality and recurrence rates. Current treatments often have limitations, prompting researchers to explore novel anti-tumor substances develop new drugs. Flavonoids, natural compounds with diverse biological activities, are gaining increasing attention in this regard. We searched from PubMed, Web of Science, SpringerLink other databases find the relevant literature last two decades. Using "gastric cancer", "stomach cancers", "flavonoid", "bioflavonoid", "2-Phenyl-Chromene" as keywords, were searched, then analyzed summarized mechanism flavonoids treatment GC. It was revealed that involves inhibiting growth, proliferation, invasion, metastasis, well inducing cell death through various processes such apoptosis, autophagy, ferroptosis, pyroptosis. Additionally, combining chemotherapeutic agents like 5-FU platinum can potentially reduce chemoresistance. Flavonoids also demonstrated enhanced activity when used combination products. Consequently, review proposes innovative perspectives for development anti-GC agents.
Language: Английский
Citations
11