Neuroscience & Biobehavioral Reviews,
Journal Year:
2025,
Volume and Issue:
unknown, P. 106131 - 106131
Published: April 1, 2025
People
diagnosed
with
cancer
who
undergo
chemotherapy
commonly
encounter
cognitive
changes,
particularly
in
executive
functions
(EFs).
EFs
support
goal-directed
behaviours,
EF
deficits
implicated
various
neurocognitive
impairments.
We
conducted
five
meta-analyses
of
the
rodent
models
to
investigate
impact
across
domains.
A
systematic
search
PubMed,
Web
Science,
Scopus,
and
PsycINFO
yielded
56
eligible
papers.
Our
findings
supported
clinical
literature
suggesting
selective
on
different
Specifically,
chemotherapy-treated
animals
performed
significantly
more
poorly
than
controls
tasks
assessing
working
memory,
behavioural
flexibility,
problem-solving,
no
significant
group
differences
inhibition
or
attention.
Subgroup
analyses
revealed
that
alkylating
agents,
antitumor
antibiotics,
combination
therapies
were
strongly
associated
memory
deficits,
whereas
mitotic
inhibitors
not.
Rodent
species,
strain,
age,
sex,
number
treatments,
time
assessment
since
end
treatment
did
not
moderate
drug
effect
any
assessed
To
increase
generalisability
translational
validity
results,
overall
reporting
quality
animal
studies
needs
be
improved
details
randomisation,
blinding,
sample
sizes,
criteria
for
exclusions.
BMC Cancer,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: Feb. 25, 2025
Cancer
survivors
may
experience
accelerated
biological
aging,
increasing
their
risk
of
mortality.
However,
the
association
between
phenotypic
age
acceleration
(PAA)
and
mortality
among
cancer
remains
unclear.
This
study
aimed
to
evaluate
relationship
PAA
all-cause
mortality,
cancer-specific
non-cancer
adult
in
United
States.
We
utilized
data
from
National
Health
Nutrition
Examination
Survey
(NHANES)
1999
2018,
including
2,643
(unweighted)
patients
aged
≥
20
years.
Phenotypic
was
calculated
using
ten
physiological
biomarkers,
residuals
regressing
on
chronological
(age
residuals,
AAR)
were
used
determine
status.
Participants
divided
into
without
groups
based
sign
residuals.
Weighted
Cox
proportional
hazards
regression
models
assess
adjusting
for
demographic
characteristics,
lifestyle
factors,
comorbidities.
Restricted
cubic
spline
(RCS)
employed
explore
dose-response
AAR
Over
a
median
follow-up
9.16
years,
991
participants
died.
After
multiple
covariates,
significantly
associated
with
increased
risks
(HR
=
2.07;
95%
CI:
1.69–2.54),
2.15;
1.52–3.04),
2.06;
1.66–2.57).
Each
one-unit
increase
4%
all-cause,
cancer-specific,
1.04;
1.03–1.05).
RCS
indicated
linear
Among
U.S.
survivors,
is
serve
as
an
important
biomarker
predicting
prognosis
survivors.
Neuroscience & Biobehavioral Reviews,
Journal Year:
2025,
Volume and Issue:
unknown, P. 106131 - 106131
Published: April 1, 2025
People
diagnosed
with
cancer
who
undergo
chemotherapy
commonly
encounter
cognitive
changes,
particularly
in
executive
functions
(EFs).
EFs
support
goal-directed
behaviours,
EF
deficits
implicated
various
neurocognitive
impairments.
We
conducted
five
meta-analyses
of
the
rodent
models
to
investigate
impact
across
domains.
A
systematic
search
PubMed,
Web
Science,
Scopus,
and
PsycINFO
yielded
56
eligible
papers.
Our
findings
supported
clinical
literature
suggesting
selective
on
different
Specifically,
chemotherapy-treated
animals
performed
significantly
more
poorly
than
controls
tasks
assessing
working
memory,
behavioural
flexibility,
problem-solving,
no
significant
group
differences
inhibition
or
attention.
Subgroup
analyses
revealed
that
alkylating
agents,
antitumor
antibiotics,
combination
therapies
were
strongly
associated
memory
deficits,
whereas
mitotic
inhibitors
not.
Rodent
species,
strain,
age,
sex,
number
treatments,
time
assessment
since
end
treatment
did
not
moderate
drug
effect
any
assessed
To
increase
generalisability
translational
validity
results,
overall
reporting
quality
animal
studies
needs
be
improved
details
randomisation,
blinding,
sample
sizes,
criteria
for
exclusions.
