Non-coding RNAs in hepatocellular carcinoma: Insights into regulatory mechanisms, clinical significance, and therapeutic potential DOI Creative Commons

Han Qin,

Mengchen Wang,

Xi Dong

et al.

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: Oct. 10, 2022

Hepatocellular carcinoma (HCC) is a complex and heterogeneous malignancy with high incidence poor prognosis. In addition, owing to the lack of diagnostic prognostic markers, current multimodal treatment options fail achieve satisfactory outcomes. Tumor immune microenvironment (TIME), angiogenesis, epithelial-mesenchymal transition (EMT), invasion, metastasis, metabolism, drug resistance are important factors influencing tumor development therapy. The intercellular communication these processes mediated by variety bioactive molecules regulate pathophysiological in recipient cells. Among molecules, non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long (lncRNAs), circular (circRNAs), account for large part human transcriptome, their dysregulation affects progression HCC. purpose this review evaluate potential regulatory mechanisms ncRNAs HCC, summarize novel biomarkers from somatic fluids (plasma/serum/urine), explore some small-molecule modulators as drugs. Thus, through review, we aim contribute deeper understanding mechanisms, early diagnosis, prognosis, precise

Language: Английский

Breast Cancer Chemoresistance: Insights into the Regulatory Role of lncRNA DOI Open Access

Seyedeh Tayebeh Ahmadpour,

Charlotte Orré,

Priscila Bertevello

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(21), P. 15897 - 15897

Published: Nov. 2, 2023

Long noncoding RNAs (lncRNAs) are a subclass of composed more than 200 nucleotides without the ability to encode functional proteins. Given their involvement in critical cellular processes such as gene expression regulation, transcription, and translation, lncRNAs play significant role organism homeostasis. Breast cancer (BC) is second most common worldwide evidence has shown relationship between aberrant lncRNA BC development. One main obstacles control multidrug chemoresistance, which associated with deregulation multiple mechanisms efflux transporter activity, mitochondrial metabolism reprogramming, epigenetic regulation well apoptosis autophagy. Studies have large number pathways. However, underlying mechanism not clearly elucidated. In this review, we present principal chemoresistance that can be directly or indirectly regulated by lncRNA, highlighting importance controlling chemoresistance. Understanding these deep detail may interest clinical outcome patients could used therapeutic targets overcome therapy resistance.

Language: Английский

Citations

14
Exploring the role of noncoding RNAs in cancer diagnosis, prognosis, and precision medicine DOI Creative Commons
Basmah Eldakhakhny,

Abdulaziz M. Sutaih,

Moaaz A. Siddiqui

et al.

Non-coding RNA Research, Journal Year: 2024, Volume and Issue: 9(4), P. 1315 - 1323

Published: July 1, 2024

This review article studies the complex field of noncoding RNAs (ncRNAs) in cancer biology, focusing on their potential use as biomarkers and therapeutic targets. NcRNAs include circular (circRNAs), long (lncRNAs), microRNAs (miRNAs). We discuss how ncRNAs affect gene expression cancerous cells, spread cancer, metastasis. The illustrates pathways through which can oncogenesis, tumor suppression, resistance. It also assesses clinical uses non-coding (ncRNAs), including utility diagnosis, prognosis. Besides, for personalized therapy is documented. Finally, it concluded that understanding role ncRNA importance regarding carcinogenesis, therapy.

Language: Английский

Citations

5
Advancements in long non-coding RNA-based therapies for cancer: targeting, delivery, and clinical implications DOI
Muhammad Ammad, Zeeshan Javed, Haleema Sadia

et al.

Medical Oncology, Journal Year: 2024, Volume and Issue: 41(11)

Published: Oct. 20, 2024

Language: Английский

Citations

5
A review of non-coding RNA related to NF-κB signaling pathway in the pathogenesis of osteoarthritis DOI
Tong Feng, Qiaofeng Wu

International Immunopharmacology, Journal Year: 2022, Volume and Issue: 106, P. 108607 - 108607

Published: Feb. 15, 2022

Language: Английский

Citations

20
Non-coding RNAs in hepatocellular carcinoma: Insights into regulatory mechanisms, clinical significance, and therapeutic potential DOI Creative Commons

Han Qin,

Mengchen Wang,

Xi Dong

et al.

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: Oct. 10, 2022

Hepatocellular carcinoma (HCC) is a complex and heterogeneous malignancy with high incidence poor prognosis. In addition, owing to the lack of diagnostic prognostic markers, current multimodal treatment options fail achieve satisfactory outcomes. Tumor immune microenvironment (TIME), angiogenesis, epithelial-mesenchymal transition (EMT), invasion, metastasis, metabolism, drug resistance are important factors influencing tumor development therapy. The intercellular communication these processes mediated by variety bioactive molecules regulate pathophysiological in recipient cells. Among molecules, non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long (lncRNAs), circular (circRNAs), account for large part human transcriptome, their dysregulation affects progression HCC. purpose this review evaluate potential regulatory mechanisms ncRNAs HCC, summarize novel biomarkers from somatic fluids (plasma/serum/urine), explore some small-molecule modulators as drugs. Thus, through review, we aim contribute deeper understanding mechanisms, early diagnosis, prognosis, precise

Language: Английский

Citations

20