The Impact of COVID-19 on the Diagnosis and Treatment of Lung Cancer at a Canadian Academic Center: A Retrospective Chart Review

Current Oncology, Journal Year: 2021, Volume and Issue: 28(6), P. 4247 - 4255

Published: Oct. 20, 2021

The large burden of COVID-19 on health care systems worldwide has raised concerns among medical oncologists about the impact diagnosis and treatment lung cancer patients. In this retrospective cohort study, we investigated before during era. New diagnoses decreased by 34.7% pandemic with slightly more advanced stages disease, there was a significant increase in utilization radiosurgery as first definitive treatment, decrease both systemic well surgery compared to pre-COVID-19 There no delay starting chemotherapy radiation time. However, observed seems have had major at our center patterns Many fear that they will see an newly diagnosed patients coming year. This study is still ongoing further data be collected analyzed better understand total patient population.

Language: Английский

---

Lung Cancer and Severe Acute Respiratory Syndrome Coronavirus 2 Infection: Identifying Important Knowledge Gaps for Investigation

Journal of Thoracic Oncology, Journal Year: 2021, Volume and Issue: 17(2), P. 214 - 227

Published: Nov. 10, 2021

Language: Английский

---

Robotic versus Video-Assisted Thoracic Surgery for Lung Cancer: Short-Term Outcomes of a Propensity Matched Analysis

Cancers, Journal Year: 2023, Volume and Issue: 15(8), P. 2391 - 2391

Published: April 21, 2023

Robot-assisted thoracic surgery (RATS) has gained popularity for the treatment of lung cancer, but its quality outcome measures are still being evaluated. The purpose this study was to compare perioperative outcomes cancer resection using RATS versus video-assisted (VATS). To achieve aim, we conducted a retrospective analysis consecutive patients who underwent between July 2015 and December 2020. A propensity-matched performed based on patients' performance status, forced expiratory volume in 1 s% predicted, diffusing capacity lungs carbon monoxide% surgical procedure (lobectomy or segmentectomy). Following propensity matching, total 613 were included analysis, which 328 RATS, 285 VATS, with satisfactory indicators. results indicated that had significantly longer operating time than VATS (132.4 ± 37.3 122.4 27.7 min; mean difference 10 min 95% CI [confidence interval], 4.2 15.9

Language: Английский

---

Report on lung cancer surgery during COVID-19 pandemic at a high volume US institution

Journal of Thoracic Disease, Journal Year: 2022, Volume and Issue: 14(8), P. 2874 - 2879

Published: July 21, 2022

The impact of COVID-19 has been felt in every field medicine. We sought to understand how lung cancer surgery was affected at a high volume institution. hypothesized that patients would wait longer for surgery, have more advanced tumors, and experience complications during the crisis.A retrospective review conducted, comparing pathologically confirmed non-small cell (NSCLC) surgical cases performed 2019 from March May 2020, height crisis. Clinical pathologic stage, tumor size, time follow up time, were evaluated.A total 375 vs. 58 2020. Overall, there no differences distribution clinical stages or median times between groups (COVID-19 16.5 days pre-COVID-19 17 days, P=0.54), nor when subdivided into Stage I-II III-IV. Case lowest April 2020 with 6 37 2019, P<0.01. Tumor size clinically larger group (median 2.1 1.9 cm, P=0.05) but not final pathology. No observed 31.0% 30.9%, P=1.00). tested positive disease their hospital stay by 15 first follow-up.Surgical different among undergoing before pandemic. Importantly, became infected as result stay. significant decrease is concerning untreated cancers may progress without proper treatment.

Language: Английский

---

Three-year survival follow-up of patients with gastrointestinal cancer treated during the COVID-19 pandemic in Spain: data from the PANDORA-TTD20 study

The Oncologist, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 16, 2024

Abstract Introduction The initial SARS-CoV-2 pandemic wave in Spain 2020 precipitated significant paradigm shifts gastrointestinal oncology patient management. This study captures the “Zeitgeist” of this period by analyzing adaptive strategies, treatment modifications, and survival outcomes, leveraging a 3-year follow-up perspective to extract insights from unprecedented experience. Methods We conducted multicenter, retrospective cohort utilizing RETUD-TTD registry, encompassing 703 patients across 19 Spanish centers April 2020. evaluated alterations clinical practice, therapeutic approaches, coronavirus disease 2019 (COVID-19)-related impacts, survival. A Bayesian hierarchical model was employed identify potential regional-specific frailties. Results peak catalyzed substantial oncological care delivery. Outpatient consultations decreased 13%, with notable selection bias toward cases more favorable prognostic indicators. Multidisciplinary tumor board discussions were significantly curtailed (eg, mean monthly colorectal cancer discussed reduced 40 23), compromising qualitative measures. occurred concurrently an average over 3 oncologists per center on medical leave. Contrary concerns, healthcare system demonstrated remarkable resilience. majority received standard-of-care therapies regulatory approval, albeit regimen modifications 15% cases. These adaptations included extended dosing intervals, dose intensity modulations, transitions oral formulations while maintaining unexpectedly stable long-term outcomes. frailty detected minimal unmeasured factors related geographic location, type pandemic-induced adaptation did not impact revealed that 2019’s less pronounced than other core variables. Conclusions decentralized exhibited robustness managing pre-pandemic diagnosed malignancies, despite asymmetrical, occasionally severe organizational disruptions. gleaned experience could inform future crisis preparedness strategies optimize provision during subsequent public health emergencies.

Language: Английский

---

Narrowing the therapeutic window?—A case-control study on the influence of the COVID-19 pandemic on the primary UICC stage of NSCLC

Journal of Thoracic Disease, Journal Year: 2023, Volume and Issue: 15(3), P. 1106 - 1114

Published: March 1, 2023

General clinical perception suggests a decline in the diagnosis and treatment of lung cancer during SARS-CoV-2 pandemic. Early non-small cell (NSCLC) is crucial therapeutic regimes as early stages are potentially curable by operation alone or with combined therapy. Pandemic-triggered overload healthcare system may have prolonged NSCLC, possibly leading to higher tumor at first diagnosis. This study aims identify how COVID-19 affected distribution Union for International Cancer Control (UICC) stage NSCLC diagnosis.A retrospective case-control was conducted, including all patients receiving their regions Leipzig Mecklenburg-Vorpommern (MV) between January 2019 March 2021. Patient data were retrieved from registries city federal state MV. Ethical approval this evaluation archived, anonymized patient waived Scientific Committee Medical Faculty, University. Three investigation periods defined effects high incidences SARS-COV-2: curfew period an enacted security measure, incidence rates aftermath incidences. Differences UICC these pandemic studied Mann-Whitney-U-Test. Pearson's correlation calculated examine changes operability.The number diagnosed dropped substantially periods. There significant difference status imposed measures (P=0.016). N-status differed significantly (P=0.022) decrease N0- increase N3-status, respectively, while N1- N2-status remained relatively unaffected. No phase showed led delay two examined regions. resulted upon However, no inoperable shown. It remains be seen, will affect overall prognosis involved patients.

Language: Английский

---

The Collateral Damage of the Pandemic on Non-COVID Related Pneumothorax Patients: A Retrospective Cohort Study

Journal of Clinical Medicine, Journal Year: 2022, Volume and Issue: 11(3), P. 795 - 795

Published: Feb. 1, 2022

Since the onset of COVID-19 pandemic, there have been many reported cases showing consequences-or collateral damages-of on patients with non-COVID-related diseases. This study aimed to compare clinical manifestations and treatment results pneumothorax before during pandemic. We retrospectively reviewed who visited our hospital pandemic The primary outcome was difference in amount between two periods, secondary them. Multivariable logistic regression conducted find risk factors related massive pneumothorax. There were 122 88 pre-pandemic groups, respectively. no significant groups respect preoperative demographic variables. However, median significantly higher group (pre-pandemic: 34.75% [interquartile range (IQR) 18.30-62.95] vs. pandemic: 53.55% [IQR 33.58-88.80], p < 0.0001) more frequent (52.3% 30.3%, = 0.002). Furthermore, experienced re-expansion pulmonary edema after treatments (p 0.0366). In multivariable analysis, (OR: 2.70 [95% CI 1.49-4.90], 0.0011) occurrence During presented a larger size had edema, even country that handled relatively well.

Language: Английский

---

Lung cancer surgical treatment during the pandemic: a challenging situation

Journal of Thoracic Disease, Journal Year: 2022, Volume and Issue: 14(10), P. 3677 - 3680

Published: Aug. 26, 2022

Language: Английский

---

CT Scan-Guided Fine Needle Aspiration Cytology for Lung Cancer Diagnosis through the COVID-19 Pandemic: What We Have Learned

Tomography, Journal Year: 2023, Volume and Issue: 9(2), P. 759 - 767

Published: March 31, 2023

Novel coronavirus-related disease (COVID-19) has profoundly influenced hospital organization and structures worldwide. In Italy, the Lombardy Region, with almost 17% of Italian population, rapidly became most severely affected area since pandemic beginning. The first following COVID-19 surges significantly lung cancer diagnosis subsequent management. Much data have been already published regarding therapeutic repercussions whereas very few reports focused on consequences diagnostic procedures.We, here, would like to analyze novel performed in our Institution Norther Italy where we faced earliest largest outbreaks Italy.We discuss, detail, strategies developed perform biopsies safe pathways created emergency settings protect patients phases. Quite unexpectedly, no significant differences emerged between cases enrolled during those before, two populations were homogeneous considering composition complication rates.By pointing out role multidisciplinarity contexts, these will be help future for designing tailored manage a real-life setting.

Language: Английский

---

The COVID-19 Pandemic and Cancer Surgery

Indian Journal of Surgical Oncology, Journal Year: 2021, Volume and Issue: 12(S2), P. 229 - 231

Published: Nov. 4, 2021

Language: Английский

---