Biomedicine & Pharmacotherapy,
Journal Year:
2022,
Volume and Issue:
156, P. 113923 - 113923
Published: Oct. 29, 2022
Malignant
tumors
are
non-communicable
diseases
that
affect
human
life
health
and
quality
of
life.
Anti-tumour-related
research
has
also
been
the
focus
difficulty
in
oncology
research.
With
rise
metabolomics,
tumour
biology,
theory
reprogramming,
amino
acid
metabolic
reprogramming
become
a
new
target
for
antitumor
Amino
acids
provide
biomolecules
such
as
nucleotides
cell
proliferation,
invasion,
immune
escape
processes.
They
essential
metabolites
activation
effects
microenvironment.
Abnormal
changes
metabolism
closely
related
to
development
immunity.
Some
proteins
or
critical
enzymes
their
pathways
can
be
used
diagnosis
prognosis
assessment
markers.
Therefore,
this
paper
reviews
on
proliferation
abnormal
alterations
during
cycle
analyzes
prospects
therapeutic
drugs
targeting
metabolism.
This
provides
theoretical
references
in-depth
study
regulation
its
possible
targets.
Cells,
Journal Year:
2022,
Volume and Issue:
11(5), P. 768 - 768
Published: Feb. 22, 2022
Immunometabolism
is
an
emerging
discipline
in
cancer
immunotherapy.
Tumor
tissues
are
heterogeneous
and
influenced
by
metabolic
reprogramming
of
the
tumor
immune
microenvironment
(TIME).
In
TIME,
multiple
cell
types
interact,
cells
compete
for
limited
nutrients,
resulting
altered
anticancer
immunity.
Therefore,
individual
may
influence
outcomes
Understanding
competition
access
to
nutrients
between
could
reveal
breadth
complexity
TIME
aid
developing
novel
therapeutic
approaches
cancer.
this
review,
we
highlight
that,
when
prevailing
type
gains
certain
advantages
over
other
types;
instance,
if
prevail
against
former
resistance.
Thus,
a
strategy
needed
selectively
suppress
such
resistant
cells.
Although
challenging,
concept
type-specific
pathway
inhibition
potent
new
Journal of Clinical Medicine,
Journal Year:
2022,
Volume and Issue:
11(3), P. 721 - 721
Published: Jan. 29, 2022
Colorectal
cancer
(CRC)
is
a
major
public
health
burden
and
one
of
the
leading
causes
cancer-related
deaths
worldwide.
Screening
programs
facilitate
early
diagnosis
can
help
to
reduce
poor
outcomes.
Serum
metabolomics
extract
vital
molecular
information
that
may
increase
sensitivity
specificity
colonoscopy
in
combination
with
histopathological
examination.
The
present
study
identifies
serum
metabolite
patterns
treatment-naïve
patients,
diagnosed
either
advanced
adenoma
(AA)
or
CRC
screenings,
framework
SAKKOPI
(Salzburg
Colon
Cancer
Prevention
Initiative)
program.
We
used
targeted
flow
injection
analysis
liquid
chromatography-tandem
mass
spectrometry
approach
(FIA-
LC-MS/MS)
characterise
metabolomes
an
initial
screening
cohort
two
validation
cohorts
(in
total
66
CRC,
76
AA
93
controls).
lipidome
was
significantly
perturbed,
proportion
lipid
species
being
downregulated
as
compared
controls.
predominant
alterations
observed
were
levels
lyso-lipids,
glycerophosphocholines
acylcarnitines,
but
additionally,
variations
quantity
hydroxylated
sphingolipids
could
be
detected.
Changed
amino
acid
metabolism
restricted
mainly
metabolites
arginine/dimethylarginine/NO
synthase
pathway.
identified
metabolic
divergences
set
foundation
for
mechanistic
studies
biochemical
pathways
become
deregulated
during
progression
through
carcinoma
sequence
highlight
key
importance
metabolites.
Biomarkers
related
these
improve
diagnosis,
well
monitoring
therapies.
Biomedicine & Pharmacotherapy,
Journal Year:
2022,
Volume and Issue:
156, P. 113923 - 113923
Published: Oct. 29, 2022
Malignant
tumors
are
non-communicable
diseases
that
affect
human
life
health
and
quality
of
life.
Anti-tumour-related
research
has
also
been
the
focus
difficulty
in
oncology
research.
With
rise
metabolomics,
tumour
biology,
theory
reprogramming,
amino
acid
metabolic
reprogramming
become
a
new
target
for
antitumor
Amino
acids
provide
biomolecules
such
as
nucleotides
cell
proliferation,
invasion,
immune
escape
processes.
They
essential
metabolites
activation
effects
microenvironment.
Abnormal
changes
metabolism
closely
related
to
development
immunity.
Some
proteins
or
critical
enzymes
their
pathways
can
be
used
diagnosis
prognosis
assessment
markers.
Therefore,
this
paper
reviews
on
proliferation
abnormal
alterations
during
cycle
analyzes
prospects
therapeutic
drugs
targeting
metabolism.
This
provides
theoretical
references
in-depth
study
regulation
its
possible
targets.
