Competency in Navigating Arbitrary Spaces as an Invariant for Analyzing Cognition in Diverse Embodiments

Entropy, Journal Year: 2022, Volume and Issue: 24(6), P. 819 - 819

Published: June 12, 2022

One of the most salient features life is its capacity to handle novelty and namely thrive adapt new circumstances changes in both environment internal components. An understanding this central several fields: evolution form function, design effective strategies for biomedicine, creation novel forms via chimeric bioengineering technologies. Here, we review instructive examples living organisms solving diverse problems propose competent navigation arbitrary spaces as an invariant thinking about scaling cognition during evolution. We argue that our innate recognize agency intelligence unfamiliar guises lags far behind ability detect it familiar behavioral contexts. The multi-scale competency essential adaptive potentiating providing top-down control (not micromanagement) address complex disease injury. observer-focused viewpoint agnostic scale implementation, illustrating how pivoted similar explore exploit metabolic, transcriptional, morphological, finally 3D motion spaces. By generalizing concept behavior, gain perspectives on evolution, system-level biomedical interventions, construction bioengineered intelligences. This framework a first step toward relating highly embodiments, which will be progress artificial regenerative medicine thriving world increasingly populated by synthetic, bio-robotic, hybrid beings.

Language: Английский

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Darwin’s agential materials: evolutionary implications of multiscale competency in developmental biology

Cellular and Molecular Life Sciences, Journal Year: 2023, Volume and Issue: 80(6)

Published: May 8, 2023

Abstract A critical aspect of evolution is the layer developmental physiology that operates between genotype and anatomical phenotype. While much work has addressed mechanisms evolvability specific genetic architectures with emergent complexity, one not been sufficiently explored: implications morphogenetic problem-solving competencies for evolutionary process itself. The cells works are passive components: rather, they have numerous capabilities behavior because derive from ancestral unicellular organisms rich repertoires. In multicellular organisms, these must be tamed, can exploited, by process. Specifically, biological structures a multiscale competency architecture where cells, tissues, organs exhibit regulative plasticity—the ability to adjust perturbations such as external injury or internal modifications still accomplish adaptive tasks across metabolic, transcriptional, physiological, problem spaces. Here, I review examples illustrating how physiological circuits guiding cellular collective impart computational properties agential material serves substrate then explore ways in which intelligence during morphogenesis affect evolution, providing new perspective on search This key feature software life helps explain remarkable speed robustness sheds light relationship genomes functional phenotypes.

Language: Английский

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Principled Limitations on Self-Representation for Generic Physical Systems

Entropy, Journal Year: 2024, Volume and Issue: 26(3), P. 194 - 194

Published: Feb. 24, 2024

The ideas of self-observation and self-representation, the concomitant idea self-control, pervade both cognitive life sciences, arising in domains as diverse immunology robotics. Here, we ask a very general way whether, to what extent, these make sense. Using generic model physical interactions, prove theorem several corollaries that severely restrict applicable notions self-observation, self-control. We show, particular, adding observational, representational, or control capabilities meta-level component system cannot, even principle, lead complete representation whole. conclude self-representation can at best be heuristic, self models general, empirically tested by systems implement them.

Language: Английский

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A computational model of cell membrane bioelectric polarization and depolarization, connected with cell proliferation, in different tissue geometries

Journal of Theoretical Biology, Journal Year: 2022, Volume and Issue: 557, P. 111338 - 111338

Published: Nov. 4, 2022

Language: Английский

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Morphoceuticals: Perspectives for discovery of drugs targeting anatomical control mechanisms in regenerative medicine, cancer and aging

Drug Discovery Today, Journal Year: 2023, Volume and Issue: 28(6), P. 103585 - 103585

Published: April 12, 2023

Morphoceuticals are a new class of interventions that target the setpoints anatomical homeostasis for efficient, modular control growth and form. Here, we focus on subclass: electroceuticals, which specifically cellular bioelectrical interface. Cellular collectives in all tissues form networks via ion channels gap junctions process morphogenetic information, controlling gene expression allowing cell to adaptively dynamically pattern formation. Recent progress understanding this physiological system, including predictive computational models, suggests targeting interfaces can embryogenesis maintain shape against injury, senescence tumorigenesis. We propose roadmap drug discovery focused manipulating endogenous bioelectric signaling regenerative medicine, cancer suppression antiaging therapeutics.

Language: Английский

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Bioelectric pharmacology of cancer: A systematic review of ion channel drugs affecting the cancer phenotype

Progress in Biophysics and Molecular Biology, Journal Year: 2024, Volume and Issue: 191, P. 25 - 39

Published: July 5, 2024

Language: Английский

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Competency in Navigating Arbitrary Spaces: Intelligence as an Invariant for Analyzing Cognition in Diverse Embodiments

Published: April 24, 2022

One of the most salient features life is its capacity to handle novelty: thrive and adapt new circumstances changes both environment internal components. An understanding this central several fields: evolution form function, design effective strategies for biomedicine, creation novel forms via chimeric bioengineering technologies. Here, we review instructive examples living organisms solving diverse problems, propose competent navigation in arbitrary spaces as an invariant thinking about scaling cognition during evolution. We argue that our innate recognize agency intelligence unfamiliar guises lags far behind ability detect it familiar behavioral contexts. The multi-scale competency essential adaptive potentiating providing top-down control (not micromanagement) address complex disease injury. observer-focused viewpoint agnostic scale implementation, illustrating how pivoted similar explore exploit metabolic, transcriptional, morphological, finally 3D motion spaces. By generalizing concept behavior, gain perspectives on evolution, system-level biomedical interventions, construction bioengineered intelligences. This framework a first step toward relating highly embodiments, which will be progress artificial regenerative medicine, thriving world increasingly populated by synthetic, bio-robotic, hybrid beings.

Language: Английский

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Bioelectricity of non-excitable cells and multicellular pattern memories: Biophysical modeling

Physics Reports, Journal Year: 2022, Volume and Issue: 1004, P. 1 - 31

Published: Dec. 22, 2022

Language: Английский

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The Sentient Cell

Oxford University Press eBooks, Journal Year: 2023, Volume and Issue: unknown

Published: Oct. 5, 2023

Abstract This volume is the natural follow-up to Arthur Reber’s 2019 book, The First Minds: Caterpillars, ‘Karyotes, and Consciousness (TFM). In that earlier work, Cellular Basis of (CBC) theory was developed based on a number efforts published in variety journals between 1997 as well talks, colloquia, presentations at conferences. core proposition TFM life mind are co-terminous. All organisms, all species extant extinct, sentient. have an existentially secure consciousness—without which they would been evolutionary dead-ends, unable survive chaotic, dangerous environment first appeared. And, importantly, forms sentience, cognitive functioning right up including those expressed by humans, evolved from original expression consciousness birth prokaryotes. unicellular widely accepted, foundational principle biological social sciences. CBC simply applies same sentience.

Language: Английский

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Asymptotic burnout and homeostatic awakening: a possible solution to the Fermi paradox?

Journal of The Royal Society Interface, Journal Year: 2022, Volume and Issue: 19(190)

Published: May 1, 2022

Previous studies show that city metrics having to do with growth, productivity and overall energy consumption scale superlinearly, attributing this the social nature of cities. Superlinear scaling results in crises called 'singularities', where population demand tend infinity a finite amount time, which must be avoided by ever more frequent 'resets' or innovations postpone system's collapse. Here, we place emergence cities planetary civilizations context major evolutionary transitions. With perspective, hypothesize once civilization transitions into state can described as one virtually connected global city, it will face an 'asymptotic burnout', ultimate crisis singularity-interval time becomes smaller than innovation. If develops capability understand its own trajectory, have window affect fundamental change prioritize long-term homeostasis well-being over unyielding growth-a consciously induced trajectory 'homeostatic awakening'. We propose new resolution Fermi paradox: either collapse from burnout redirect themselves prioritizing homeostasis, cosmic expansion is no longer goal, making them difficult detect remotely.

Language: Английский

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