Advances in clinical chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 93 - 142
Published: Dec. 14, 2024
Language: Английский
Periodontology 2000, Journal Year: 2023, Volume and Issue: 96(1), P. 250 - 280
Published: Dec. 10, 2023
The oral squamous cell carcinoma (OSCC) 5 year survival rate of 41% has marginally improved in the last few years, with less than a 1% improvement per from 2005 to 2017, higher rates when detected at early stages. Based on histopathological grading dysplasia, it is estimated that severe dysplasia malignant transformation 7%-50%. Despite these numbers, does not reliably predict its clinical behavior. Thus, more accurate markers predicting progression cancer would enable better targeting lesions for closer follow-up, especially stages disease. In this context, molecular biomarkers derived genetics, proteins, and metabolites play key roles oncology. These signatures can help likelihood OSCC development and/or have potential detect disease an stage and, support treatment decision-making responsiveness. Also, identifying reliable detection be obtained non-invasively enhance management OSCC. This review will discuss emerged different biological areas, including genomics, transcriptomics, proteomics, metabolomics, immunomics, microbiomics.
Language: Английский
Citations
30
Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)
Published: April 2, 2025
The Wnt signaling pathway plays a crucial role in development and tissue homeostasis, regulating key cellular processes such as proliferation, differentiation, apoptosis. However, its abnormal activation is strongly associated with tumorigenesis, metastasis, resistance to therapy, making it vital target for cancer treatment. This review provides comprehensive insight into the of cancer, examining normal physiological functions, dysregulation malignancies, therapeutic potential. We emphasize importance predicting sensitivity identify biomarkers across various types. Additionally, we address challenges future prospects Wnt-targeted therapies, including biomarker discovery, advancements emerging technologies, their application clinical practice.
Language: Английский
Citations
1
BMC Cancer, Journal Year: 2024, Volume and Issue: 24(1)
Published: May 6, 2024
Abstract Background 5-Fluorouracil (5FU) is a primary chemotherapeutic agent used to treat oral squamous cell carcinoma (OSCC). However, the development of drug resistance has significantly limited its clinical application. Therefore, there an urgent need determine mechanisms underlying and identify effective targets. In recent years, Wingless Int-1 (WNT) signaling pathway been increasingly studied in cancer resistance; however, role WNT3, ligand canonical WNT pathway, OSCC 5FU-resistance not clear. This study delved into this potential connection. Methods 5FU-resistant lines were established by gradually elevating concentration culture medium. Differential gene expressions between parental resistant cells underwent RNA sequencing analysis, which was then substantiated via Real-time quantitative PCR (RT-qPCR) western blot tests. The influence on chemoresistance ascertained through WNT3 knockdown or overexpression. inhibitor methyl 3-benzoate (MSAB) probed for capacity boost 5FU efficacy. Results study, WNT/β-catenin notably activated lines, confirmed transcriptome RT-qPCR, verification. Additionally, key responsible activation, identified. By knocking down overexpressing cells, we found that promoted OSCC. addition, MSAB reversed cells. Conclusions These data underscored activation identified promoting effect upregulation carcinoma. may provide new therapeutic strategy reversing
Language: Английский
Citations
5
Cancers, Journal Year: 2022, Volume and Issue: 14(15), P. 3834 - 3834
Published: Aug. 8, 2022
In 2000 and 2011, Hanahan Weinberg published two papers in which they defined the characteristics that cells must fulfil order to be considered neoplastic all types of tumours affect humans, authors called “hallmarks cancer”. These have represented a milestone our understanding biology many cancers made it possible reach high levels scientific evidence relation prognostic impact these hallmarks on different tumour types. However, date, there is no study globally analyses evidence-based knowledge importance oral oropharyngeal squamous cell carcinomas. For this reason, we set out conduct scoping review systematic reviews with aim detecting gaps relevance cancer proposed by cancer, potentially malignant disorders, point future lines research field.
Language: Английский
Citations
20
Head and Neck Pathology, Journal Year: 2025, Volume and Issue: 19(1)
Published: Jan. 7, 2025
Language: Английский
Citations
0
Frontiers in Oral Health, Journal Year: 2025, Volume and Issue: 6
Published: March 27, 2025
Objectives The purpose of this systematic review and meta-analysis was to appraise, both quantitatively qualitatively, the extant evidence regarding role EGFR upregulation in predicting malignant transformation risk associated with oral potentially disorders (OPMD). Methods A comprehensive search undertaken Web Science, Embase, MEDLINE (via PubMed), Scopus databases for longitudinal primary-level articles, whether prospective or retrospective design, without restrictions on language publication date. QUIPS tool employed assessing potential bias. conducted addition sensitivity analyses influence small-study effects. Results In total, eight studies, which were treated as nine distinct units analytical purposes, included final sample, encompassed 653 patients OPMD follow-up data. found be significantly an elevated (RR = 2.17, 95%CI 1.73–2.73, p < 0.001). Subgroup demonstrated that protein overexpression 2.02, 1.55–2.63, 0.001) gene amplification 2.70, 1.72–4.25, 0.001), nuclear staining 3.47, 1.50-8.01, 0.004) >10% cutoff point 2.27, 1.33–3.87, 0.003). Conclusion present demonstrates overexpression, assessed through immunohistochemical technique, functions a marker risk. Systematic Review Registration https://www.crd.york.ac.uk/PROSPERO/view/CRD42024626482 , identifier: CRD42024626482).
Language: Английский
Citations
0
Oral Diseases, Journal Year: 2025, Volume and Issue: unknown
Published: April 24, 2025
ABSTRACT Objectives To evaluate current evidence on prognostic factors in oral squamous cell carcinomas (OSCCs), through a comprehensive meta‐analysis of total 255 primary‐level studies (63,114 patients). Materials and Methods MEDLINE, Embase, Web Science, Scopus were searched before January 2024. The risk bias was analyzed using the Quality Prognosis Studies tool. Results Among main influential parameters have been lymph node involvement any measured forms, cN (overall survival: HR = 2.20, 95% CI 1.98–2.45, p < 0.001; disease‐specific 1.95, 1.44–2.65, 0.05; disease‐free 2.13, 1.77–2.56, 0.001), pN 2.04, 1.64–2.54, 2.83, 1.68–4.77, 2.73, 1.96–3.81, 0.001) extracapsular spread 2.12, 1.81–2.47, 2.08, 1.43–3.03, 2.27, 1.92–2.69, 0.001). In relation to T‐parameter, invasion depth greater than 5 mm strongly influenced mortality 3.19, 1.74–5.84, 1.97, 1.22–3.20, 0.006). M parameter has most relevant negative factor—although with less robust results due lack primary level studies: cM 2.95, 2.09–4.17, 6.26, 1.54–25.42, 0.01; 2.78, 1.57–4.93, 0.001); pM 5.19, 1.94–13.90, 0.01). Conclusions death recurrence is increased if diagnosis achieved when neck nodes are affected, tumor large, or given rise distant metastases, which points imperative need implement measures for improving early disease by acting all actors responsible diagnostic delay OSCC.
Language: Английский
Citations
0
Frontiers in Oral Health, Journal Year: 2025, Volume and Issue: 6
Published: May 12, 2025
Oral Squamous Cell Carcinoma (OSCC), the main form of oral cancer, is a major health problem globally that affects 400,000 people every year. It has been postulated periodontitis, chronic inflammatory disease characterized by alveolar bone resorption, an independent risk factor for OSCC. However, mechanisms underlying this link are not fully elucidated. demonstrated Wnt/β-catenin pathway key to transformation potentially malignant disorders (OPMD) towards OSCC (i.e., leukoplakia), particularly in OPMD histologically diagnosed as dysplasia. Using GEO database carcinogenesis (GSE85195), transcriptional modification 19 Wnt ligands and 4 regulatory proteins β-catenin, including E-cadherin, APC, AXIN GSK3B, during leukoplakia, early late stages OSCC, was determined. The expression these targets also assessed periodontitis (GEO GSE223924). Together, it found Wnt3, Wnt3a, Wnt5b Wnt7b concomitantly upregulated carcinogenesis. With results, information retrieved from literature, review discusses potential role molecular mechanism could interlink
Language: Английский
Citations
0
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(15), P. 11888 - 11888
Published: July 25, 2023
The aim of this systematic review and meta-analysis was to evaluate the current evidence in relation clinicopathological prognostic significance epidermal growth factor receptor (EGFR) overexpression patients with oral squamous cell carcinoma (OSCC). We searched MEDLINE/PubMed, Embase, Web Science, Scopus for studies published before November 2022. evaluated quality primary-level using QUIPS tool, conducted meta-analyses, examined inter-study heterogeneity via subgroup analyses meta-regressions, performed small-study effects analyses. Fifty (4631 patients) met inclusion criteria. EGFR significantly associated poor overall survival (hazard ratio [HR] = 1.38, 95% confidence intervals [CI] 1.06–1.79, p 0.02), N+ status (odds [OR] 1.37, 95%CI 1.01–1.86, 0.04), moderately–poorly differentiated OSCC (OR 1.43, CI 1.05–1.94, 0.02). In addition, better results were obtained by application a cutoff point ≥10% tumor cells (p < 0.001). conclusion, our supports that immunohistochemical assessment may be useful as biomarker OSCC.
Language: Английский
Citations
7
Cancers, Journal Year: 2022, Volume and Issue: 14(15), P. 3673 - 3673
Published: July 28, 2022
The aim of this systematic review and meta-analysis was to evaluate the current evidence on prognostic clinicopathological significance value telomerase reverse transcriptase (TERT) upregulation in patients with oral squamous cell carcinoma (OSCC). PubMed, Embase, Web Science, Scopus were searched for studies published before April 2022, not restricted by date or publication language. methodological quality primary-level critically assessed using Quality Prognosis Studies (QUIPS) tool. We carried out meta-analyses, explored heterogeneity its sources, performed subgroup, meta-regression, sensitivity, small-study effects analyses. Twenty-one (1698 patients) met inclusion criteria. TERT protein overexpression significantly associated worse overall survival (hazard ratio [HR] = 3.01, 95% CI 1.70−5.35, p < 0.001), disease-free (HR 4.03, 1.80−9.05, higher histological grade OSCC (odds [OR] 3.20, 1.83−5.62, 0.001). These large effect sizes consistently obtained homogeneous subgroups (p > 0.10, I2 0.0, respectively), which reflects a high evidence. On other hand, gene mutations constantly nonsignificant null all outcomes investigated, evidencing no value. In conclusion, our findings indicate that is indicator poor cancer. Our support immunohistochemical assessment overexpression, could probably be incorporated into evaluation OSCC.
Language: Английский
Citations
9