Prostate cancer treatment costs increase more rapidly than for any other cancer—how to reverse the trend?

The EPMA Journal, Journal Year: 2022, Volume and Issue: 13(1), P. 1 - 7

Published: March 1, 2022

According to GLOBOCAN, about 1.41 million new prostate cancer (PCa) cases were registered in the year 2020 globally. The corresponding socio-economic burden is enormous. Anti-cancer mRNA-based therapy a promising approach, principle of which currently applied for anti-COVID-19 vaccination, undergoing detailed investigation populations considering its short- and long-term effectiveness potential side effects. Pragmatically considered, it will take years or even decades make mRNA working any type cancers, if possible, individual malignancy sub-types are many specifically PCa. Actually, costs treating PCa increasing more rapidly than those other cancer. trend has be reversed now, not couple years. In general, two main components making reactive (management clinically manifested disease) treatment particularly expensive. On one hand, incidence disease metastatic as subtype. To this end, rates young middle-aged male sub-populations should taken into account contributor potentially developed later on life. patient stratification differentiate between non-metastatic (no need an extensive costly treatment) aggressive subtypes requiring personalised algorithms challenging. Considering current statistics, becomes obvious that medicine got at limit management. Multi-professional expertise unavoidable create implement anti-PCa programmes population. our strategic paper, we exemplify challenging management by providing expert recommendations primary (health risk assessment), secondary (prediction prevention PCa) tertiary (making palliative care chronic framework predictive, preventive medicine.

Language: Английский

---

Anti-prostate cancer protection and therapy in the framework of predictive, preventive and personalised medicine — comprehensive effects of phytochemicals in primary, secondary and tertiary care

The EPMA Journal, Journal Year: 2022, Volume and Issue: 13(3), P. 461 - 486

Published: July 8, 2022

Abstract According to the GLOBOCAN 2020, prostate cancer (PCa) is most often diagnosed male in 112 countries and leading cancer-related death 48 countries. Moreover, PCa incidence permanently increases adolescents young adults. Also, rates of metastasising continuously grow up populations. Corresponding socio-economic burden enormous: treatment costs increase more rapidly than for any other cancer. In order reverse current trends exploding cases costs, pragmatic decisions should be made, favour advanced populational screening programmes effective anti-PCa protection at level health-to-disease transition (sub-optimal health conditions) demonstrating highest cost-efficacy treatments. For doing this, paradigm change from reactive treatments clinically manifested predictive approach personalised prevention essential. Phytochemicals are associated with potent anti-cancer activity targeting each stage carcinogenesis including cell apoptosis proliferation, invasiveness metastatic disease. example, their positive effects demonstrated stabilising restoring mitochondrial quality, which if compromised strongly sub-optimal conditions strong predisposition aggressive sub-types. Further, phytochemicals significantly enhance response cells therapies radio- chemotherapy. Evident plant-based mitigation negative side-effects frequently observed conventional has been reported. Finally, dual anti-viral such as these silibinin have being highly relevant improved management secondary tertiary care, under pandemic conditions, since PCa-affected individuals per evidence vulnerable towards COVID-19 infection. Here, we present a comprehensive data analysis considered primary care well an disease framework predictive, preventive medicine.

Language: Английский

---

Clarifying the effect of gut microbiota on allergic conjunctivitis risk is instrumental for predictive, preventive, and personalized medicine: a Mendelian randomization analysis

The EPMA Journal, Journal Year: 2023, Volume and Issue: 14(2), P. 235 - 248

Published: May 22, 2023

Language: Английский

---

Targeting benign prostate hyperplasia treatments: AR/TGF-β/NOX4 inhibition by apocynin suppresses inflammation and proliferation

Journal of Advanced Research, Journal Year: 2023, Volume and Issue: 57, P. 135 - 147

Published: April 14, 2023

Apocynin (Apo), an NADPH oxidase (NOX) inhibitor, has been widely used to treat various inflammatory diseases. However, the therapeutic effects of Apo on benign prostatic hyperplasia (BPH), a multifactorial disease associated with chronic inflammation and hormone imbalance, remain unknown. The link between androgen signaling, reactive oxygen species (ROS), prostate cell proliferation may contribute pathogenesis BPH; therefore, aim this study was identify specific signaling pathway involved demonstrate whether anti-oxidant plays role in prevention treatment BPH. Ingenuity analysis si-RNA transfection were conducted receptor (AR) NOX4 linkage Pathological markers BPH measured by H&E staining, immunoblotting, ELISA, qRT-PCR, immunofluorescence examine effect Apo. Rats stimulated testosterone BPH-1 cells as models. AR network-mediated oxidative stress upregulated model. Next, we examined mouse In testosterone-induced rat model, alleviated pathological enlargement suppressed androgen/AR signaling. upregulation proinflammatory promoted expression factors. Furthermore, regulated TGF-β/Glut9/activin macrophage programming. cells, AR-mediated TGFB alleviating stress. activated anti-inflammatory systems polarization cells. knockdown partially abolished beneficial indicating AR-dependent contrast existing therapies, provide new application for treatment, especially BPH, targeting AR/TGF-β/NOX4 pathway.

Language: Английский

---

The Role of Different Types of microRNA in the Pathogenesis of Breast and Prostate Cancer

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(3), P. 1980 - 1980

Published: Jan. 19, 2023

Micro ribonucleic acids (microRNAs or miRNAs) form a distinct subtype of non-coding RNA and are widely recognized as one the most significant gene expression regulators in mammalian cells. Mechanistically, regulation occurs through microRNA binding with its response elements 3’-untranslated region target messenger RNAs (mRNAs), resulting post-transcriptional silencing genes, expressing mRNAs. Compared to small interfering RNAs, microRNAs have more complex regulatory patterns, making them suitable for fine-tuning expressions different tissues. Dysregulation is well known causative factors malignant cell growth. Today, there numerous data points regarding cancer transcriptomes, specificity changes various tissues, predictive value specific biomarkers. Breast (BCa) common women worldwide seriously impairs patients’ physical health. Its incidence has been predicted rise further. Mounting evidence indicates that play key roles tumorigenesis development. Prostate (PCa) commonly diagnosed cancers men. Different an important role PCa. Early diagnosis BCa PCa using very useful improving individual outcomes framework predictive, preventive, personalized (3P) medicine, thereby reducing economic burden. This article reviews types progression.

Language: Английский

---

The Carotenoid Diatoxanthin Modulates Inflammatory and Angiogenesis Pathways In Vitro in Prostate Cancer Cells

Antioxidants, Journal Year: 2023, Volume and Issue: 12(2), P. 359 - 359

Published: Feb. 2, 2023

Xanthophylls, a group of carotenoids, have attracted attention as human health benefit compounds thanks to their functionality and bioavailability. The great antioxidant anti-inflammatory abilities diatoxanthin (Dt), photoprotective xanthophyll synthetized by diatoms, were recently documented. This study investigates the capacity Dt intercept prostate cancer progression in vitro on different cell lines, exploring its role against proliferation angiogenesis. Our results highlighted chemopreventive already at low concentration (44.1 pM) suggest that Dt-induced death occurred through oxidative stress mechanisms. hypothesis was supported variations expression key genes proteins. Oxidative deaths (e.g., ferroptosis) are described types closely related pathophysiological processes many diseases, such tumors. Nonetheless, interest further strengthened ability inhibit discussed considering actual progress requirements therapy, notably for cancer.

Language: Английский

---

Inflammation-related indicators have a potential to increase overall quality of the prostate cancer management: a narrative review

Translational Andrology and Urology, Journal Year: 2023, Volume and Issue: 12(5), P. 809 - 822

Published: May 1, 2023

Background and Objective: Increasing evidence suggests that inflammation plays an essential role in cancer development progression. The levels of inflammation-related indicators are correlated with prognosis across a wide variety tumor types, including prostate (PCa), but its diagnostic prognostic value PCa remains controversial. In the present review, patients is investigated.

Language: Английский

---

The predictive, preventive, and personalized medicine of insomnia: gut microbiota and inflammation

The EPMA Journal, Journal Year: 2023, Volume and Issue: 14(4), P. 571 - 583

Published: Nov. 17, 2023

Language: Английский

---

MiR-145 inhibits cell migration and increases paclitaxel chemosensitivity in prostate cancer cells.

PubMed, Journal Year: 2023, Volume and Issue: 26(11), P. 1350 - 1359

Published: Jan. 1, 2023

Prostate cancer (PC) is one of the most commonly diagnosed malignancies among men worldwide. Paclitaxel a chemotherapeutic agent widely used to treat different types cancer. Recent studies revealed miRNAs control various genes that influence regulation many biological and pathological processes such as formation development cancer, chemotherapy resistance, etc.Between three PC cell lines (PC3, DU-145, LNCAP), PC3 showed lowest miR-145 expression was chosen for experiments. cells were treated with paclitaxel separately or in combination. To measure viability, migratory capacity, autophagy, cycle progression, apoptosis induction, MTT assay, wound-healing Annexin V/PI assay used, respectively. Moreover, quantitative real-time PCR (qRT-PCR) employed level involved apoptosis, migration, stemness properties.Obtained results illustrated transfection could enhance sensitivity increase paclitaxel-induced by modulating related genes, including Caspase-3, Caspase-9, Bax, Bcl-2. Also, combination therapy increased arrest at sub-G1 phase. cooperatively reduced migration ability related-metastatic gene expression, MMP-2, MMP-9, CD44, SOX-2. In addition, can suppress MDR1 expression.These confirmed combined inhibit proliferation chemosensitivity compared mono treatment. So, may be promising approach

Language: Английский

---

From molecular mechanisms of prostate cancer to translational applications: based on multi-omics fusion analysis and intelligent medicine

Health Information Science and Systems, Journal Year: 2023, Volume and Issue: 12(1)

Published: Dec. 18, 2023

Language: Английский

---