Radiomics Analysis of Preprocedural CT Imaging for Outcome Prediction after Transjugular Intrahepatic Portosystemic Shunt Creation

Life, Journal Year: 2024, Volume and Issue: 14(6), P. 726 - 726

Published: June 3, 2024

Purpose: To evaluate the role of radiomics in preoperative outcome prediction cirrhotic patients who underwent transjugular intrahepatic portosystemic shunt (TIPS) using “controlled expansion covered stents”. Materials and Methods: This retrospective institutional review board-approved study included undergoing TIPS with controlled stent placement. From CT images, whole liver was segmented into Volumes Interest (VOIs) at unenhanced portal venous phase. Radiomics features were extracted, collected, analyzed. Subsequently, receiver operating characteristic (ROC) curves drawn to assess which could predict patients’ outcomes. The endpoints studied 6-month overall survival (OS), development hepatic encephalopathy (HE), grade II or higher HE according West Haven Criteria, clinical response, defined as absence rebleeding ascites. A radiomic model for then designed. Results: total 76 consecutive creation enrolled. highest performances terms area under curve (AUROC) observed “clinical response” “survival 6 months” 0.755 0.767, phase, respectively. Specifically, on basal scans, accuracy, specificity, sensitivity 66.42%, 63.93%, 73.75%, At an accuracy 65.34%, a specificity 62.38%, 74.00% demonstrated. Conclusions: pre-interventional machine learning-based algorithm be useful predicting response after patients.

Language: Английский

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Predicting the Response of Patients Treated with 177Lu-DOTATATE Using Single-photon Emission Computed Tomography–Computed Tomography Image-based Radiomics and Clinical Features

Journal of Medical Signals & Sensors, Journal Year: 2024, Volume and Issue: 14(10)

Published: Oct. 1, 2024

In this study, we want to evaluate the response Lutetium-177 (

Language: Английский

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Inter- and intra-tumoral heterogeneity on [68Ga]Ga-DOTA-TATE/[68Ga]Ga-DOTA-TOC PET/CT predicts response to [177Lu]Lu-DOTA-TATE PRRT in neuroendocrine tumor patients

Deleted Journal, Journal Year: 2024, Volume and Issue: 8(1)

Published: Nov. 29, 2024

Abstract Background Indices of tumor heterogeneity on somatostatin receptor PET/CT scans may potentially serve as predictive biomarkers treatment efficacy in neuroendocrine (NET) patients undergoing [ 177 Lu]Lu-DOTA-TATE PRRT. Methods NET who underwent therapy at the University Iowa from August 2018 to February 2021 were retrospectively evaluated. Radiomic features pre-PRRT evaluated using a custom MIM Software® LesionID workflow. Conventional metrics burden, such expression and volume, calculated addition indices for each lesion (intra-lesional) then summarized across all lesions throughout body (inter-lesional). Endpoints included post-PRRT 24-month time progression (TTP) overall survival (OS). Cox regression models used assess ability imaging factors TTP OS. LASSO-penalized was build multivariable model outcome. Results Eighty with mean age 65.1 years included, most (71.3%) completing 4 cycles Median 19.1 months, OS 60 months 50%. A large degree variability between evidenced related expression. On analysis, total liver-corrected SUVmean selected TTP. The not able significantly predict (C-statistic = 0.58, 95% CI 0.50–0.62). Total skewness resulting death 0.62, 0.53–0.67), but limited, by low C-statistic. Conclusions Our exploratory analysis provides preliminary results showing that inter- intra-tumor pretreatment images therapy. However, prospective evaluation larger cohort is needed further whether comprehensive characterization within patient can help guide decisions.

Language: Английский

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SSTR-based theranostics in neuroendocrine prostate cancer (NEPC)

Clinical and Translational Imaging, Journal Year: 2022, Volume and Issue: 11(4), P. 321 - 328

Published: Dec. 12, 2022

Language: Английский

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Prediction of High Pathological Grade in Prostate Cancer Patients Undergoing [18F]-PSMA PET/CT: A Preliminary Radiomics Study

Lecture notes in computer science, Journal Year: 2024, Volume and Issue: unknown, P. 49 - 58

Published: Jan. 1, 2024

Language: Английский

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