Efficacy of Mitochondrial-Based Interventions in the Management of Clinical Depression—A Systematic Review DOI Open Access

Joshua Sauren,

David Hoehfeld,

Leif Gerrit Keferstein

et al.

Published: Sept. 22, 2023

Background: Depression, a multifaceted mental health condition, necessitates multidimensional approach to treatment. This study aimed elucidate the potential efficacy of various mitochondrial interventions, ranging from pharmacological treatments lifestyle modifications, in alleviating depressive symptoms and enhancing overall well-being assess diverse range assessments for managing depression by synthesizing findings selected studies. Methods: A systematic compilation studies, employing observational, interventional, animal-based designs, was undertaken intricate relationship between function as well signs symptoms. The PRISMA guidelines were employed conducting this review specific set selection criterion formulated team reviewers relevant papers. Results: synthesized results 21 papers highlighted these interventions target aspects depression. Hyperbaric oxygen therapy psychotherapy demonstrated significant reductions anxiety scores, with hyperbaric particularly effective improving nerve daily living activities. Whole-body cryotherapy displayed substantial improvements quality life. Frequent sauna bathing exhibited lower risk males. Dietary patterns, including Paleolithic Mediterranean diets, showcased protective effects against depression, anxiety, stress. ketogenic diet revealed promise ameliorating psychosis alongside positive metabolic changes. Fasting though challenging, associated levels without increased fatigue. Bright white light enhanced remission rates reduced scores bipolar Probiotic supplementation reducing markers, although further investigation is warranted. Conclusion: array explored underlines nature While offer hope more personalized approaches, it imperative consider variability sample sizes, methodologies among mechanisms underlying observed remain partially understood, emphasizing need continued mechanistic research. sets stage future investigations clinical practices, showcasing mitigating challenges posed paving way treatment strategies.

Language: Английский

Mitochondria: It is all about energy DOI Creative Commons

Amaloha Casanova,

Anne Wevers, Santiago Navarro‐Ledesma

et al.

Frontiers in Physiology, Journal Year: 2023, Volume and Issue: 14

Published: April 25, 2023

Mitochondria play a key role in both health and disease. Their function is not limited to energy production but serves multiple mechanisms varying from iron calcium homeostasis the of hormones neurotransmitters, such as melatonin. They enable influence communication at all physical levels through interaction with other organelles, nucleus, outside environment. The literature suggests crosstalk between mitochondria circadian clocks, gut microbiota, immune system. might even be hub supporting integrating activity across these domains. Hence, they (missing) link Mitochondrial dysfunction related metabolic syndrome, neuronal diseases, cancer, cardiovascular infectious inflammatory disorders. In this regard, diseases Alzheimer’s, Parkinson’s, amyotrophic lateral sclerosis (ALS), chronic fatigue syndrome (CFS), pain are discussed. This review focuses on understanding mitochondrial action that allow for maintenance pathways toward dysregulated mechanisms. Although have allowed us adapt changes over course evolution, turn, evolution has shaped mitochondria. Each evolution-based intervention influences its own way. use physiological stress triggers tolerance stressor, achieving adaptability resistance. describes strategies could recover functioning providing comprehensive, root-cause-focused, integrative approach recovering treating people suffering diseases.

Language: Английский

Citations

111
Metabolic reprogramming directed by super-enhancers in tumors: An emerging landscape DOI Creative Commons

Zongjiang Zhou,

Jinghe Li,

Diabate Ousmane

et al.

Molecular Therapy, Journal Year: 2024, Volume and Issue: 32(3), P. 572 - 579

Published: Feb. 6, 2024

Metabolic reprogramming is an essential hallmark of tumors, and metabolic abnormalities are strongly associated with the malignant phenotype tumor cells. This closely related to transcriptional dysregulation. Super-enhancers extremely active cis-regulatory regions in genome, can amalgamate a complex set regulatory components that crucial for establishing cell identity, promoting tumorigenesis, enhancing aggressiveness. In addition, alterations signaling pathways often accompanied by changes super-enhancers. Presently, there surge interest potential pathogenesis various tumors through regulation super-enhancers oncogenic mutations this review, we summarize functions super-enhancers, pathways, reprogramming. particular, focus on role super-enhancer metabolism its impact review also discusses prospects directions field

Language: Английский

Citations

8
Super enhancer lncRNAs: a novel hallmark in cancer DOI Creative Commons
Ping Song,

Rongyan Han,

Fan Yang

et al.

Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)

Published: April 2, 2024

Abstract Super enhancers (SEs) consist of clusters enhancers, harboring an unusually high density transcription factors, mediator coactivators and epigenetic modifications. SEs play a crucial role in the maintenance cancer cell identity promoting oncogenic transcription. enhancer lncRNAs (SE-lncRNAs) refer to either transcript from locus or interact with SEs, whose transcriptional activity is highly dependent on SEs. Moreover, these SE-lncRNAs can their associated regions cis modulate expression oncogenes key signal pathways cancers. Inhibition would be promising therapy for cancer. In this review, we summarize research different kinds cancers so far decode mechanism carcinogenesis provide novel ideas therapy.

Language: Английский

Citations

7
Fusobacterium nucleatum promotes colorectal cancer metastasis by excretion of miR-122-5p from cells via exosomes DOI Creative Commons

Mengjiao Zhang,

Yifeng Wang, L.‐C. YU

et al.

iScience, Journal Year: 2023, Volume and Issue: 26(9), P. 107686 - 107686

Published: Aug. 19, 2023

Fusobacterium nucleatum (Fn) infection and microRNAs (miRNAs) are closely associated with colorectal cancer (CRC) development, but the mechanism by which Fn regulates tumor-suppressive miRNAs via exosomes facilitates CRC metastasis remains unclear. Here, we identified that significantly increased exosomal miR-122-5p levels in serum of patients cell culture supernatants through two miRNA panels high-throughput sequencing RT-qPCR analysis. In Fn-infected patients, were negatively their expression tissues. Downregulated was demonstrated to enhance migration, invasion, abilities cells vivo vitro. Secretion into is mediated hnRNPA2B1. Mechanistically, activated TGF-β1/Smads signaling pathway promote EMT regulation miR-122-5p/FUT8 axis. conclusion, may stimulate excrete exosome-wrapped miR-122-5p, activate FUT8/TGF-β1/Smads axis metastasis.

Language: Английский

Citations

14
Super-Enhancers and Their Parts: From Prediction Efforts to Pathognomonic Status DOI Open Access

Anastasia V. Vasileva,

Marina G. Gladkova, German A. Ashniev

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(6), P. 3103 - 3103

Published: March 7, 2024

Super-enhancers (SEs) are regions of the genome that play a crucial regulatory role in gene expression by promoting large-scale transcriptional responses various cell types and tissues. Recent research suggests alterations super-enhancer activity can contribute to development progression disorders. The aim this is explore multifaceted roles super-enhancers regulation their significant implications for understanding treating complex diseases. Here, we study summarise classification constituents, possible modes interaction, cross-regulation, including RNAs (seRNAs). We try investigate opportunity SE dynamics prediction based on hierarchy enhancer single elements (enhancers) aggregated action. To further our understanding, conducted an silico experiment compare differentiate between locus-control (LCRs), shedding light enigmatic relationship LCRs SEs within human genome. Particular attention paid specific mechanisms diversity, exemplified oncological, cardiovascular, immunological diseases, as well overview several anti-SE therapies. Overall, work presents comprehensive analysis across different aiming provide insights into may act rationale future clinical interventions targeting these elements.

Language: Английский

Citations

6
A quality comparison for Xiecun Huangjiu with different aging stages based on chemical profile, aroma composition and microbial succession DOI Creative Commons
Yu Zhao, Min Li, Ping Zhan

et al.

Food Chemistry X, Journal Year: 2024, Volume and Issue: 21, P. 101132 - 101132

Published: Jan. 9, 2024

The Xiecun Huangjiu (XCHJ), an exemplary representation of North Huangjiu, exhibits a distinct and invigorating aroma predominantly formed during its aging period. In this study, we observed dynamic changes in 16 key compounds by gas chromatography-mass spectrometry (GC–MS) the XCHJ, with such as phenethylalcohol, isoamylalcohol, benzaldehyde, ethylbenzoate initially increasing then decreasing. Ultra-Performance Liquid Chromatography (UPLC) detected nineteen amino acids, total content ranging from 1901.45 to 3764.45 mg/L. High-throughput sequencing indicated that Pseudomonas, Ochrobactrum, Moesziomyces Aspergillus et al. were abundant aged XCHJ. Totally, 4 bacteria 8 fungi exhibited strong associations production. Physicochemical properties primarily interacted Aspergillus, Pseudeurotium, Thermomyces, Bacteroides Blautia. Furthermore, co-occurrence network analysis highlighted significant interactions between Pantoea, Rhodotorula, Monascus, acids. These findings provide valuable insights for regulation

Language: Английский

Citations

4
Identification of glutamine metabolism-related gene signature to predict colorectal cancer prognosis DOI Creative Commons
Yang Xie, Jun Li,

Qing Tao

et al.

Journal of Cancer, Journal Year: 2024, Volume and Issue: 15(10), P. 3199 - 3214

Published: Jan. 1, 2024

Backgrounds: Colorectal cancer (CRC) is a highly malignant gastrointestinal malignancy with poor prognosis, which imposes significant burden on patients and healthcare providers globally.Previous studies have established that genes related to glutamine metabolism play crucial role in the development of CRC.However, no yet explored prognostic significance these CRC.Methods: CRC patient data were downloaded from The Cancer Genome Atlas (TCGA), while metabolism-related obtained Molecular Signatures Database (MSigDB) database.Univariate COX regression analysis LASSO Cox utilized identify 15 associated prognosis.The risk scores calculated stratified into high-risk low-risk groups based median score.The model's efficacy was assessed using Kaplan-Meier survival receiver operating characteristic (ROC) curve analysis.Cox employed determine score as an independent factor for CRC.Differential immune cell infiltration between ssGSEA method.The clinical applicability model validated by constructing nomograms age, gender, staging, scores.Immunohistochemistry (IHC) used detect expression levels core genes.Results: We identified CRC: NLGN1, RIMKLB, UCN, CALB1, SYT4, WNT3A, NRCAM, LRFN4, PHGDH, GRM1, CBLN1, NRG1, GLYATL1, CBLN2, VWC2.Compared group, group demonstrated longer overall (OS) CRC.Clinical correlation revealed positive stage TNM CRC.Immune indicated predominance Th2 cells group.The nomogram exhibited excellent discriminatory ability OS CRC.Immunohistochemistry gene CBLN1 expressed at lower level CRC, GLYATL1 higher level.Conclusions: In summary, we successfully comprehensively analyzed signature first time.This consistently reliably predicts prognosis patients, indicating its potential metabolic target individuals CRC.

Language: Английский

Citations

4
Pan-cancer analysis of super-enhancer-induced LINC00862 and validation as a SIRT1-promoting factor in cervical cancer and gastric cancer DOI Creative Commons
Shaojun Liu, Zhaohui Wang, Lei Hu

et al.

Translational Oncology, Journal Year: 2024, Volume and Issue: 45, P. 101982 - 101982

Published: May 7, 2024

Immune checkpoints inhibitors are effective but it needs more precise biomarkers for patient selection. We explored the biological significance of LINC00862 in pan-cancer by bioinformatics. And we studied its regulatory mechanisms using chromatin immunoprecipitation and RNA assays etc. TCGA single-cell sequencing data analysis indicated that was overexpressed majority tumor stromal cells, which related with poor prognosis. expression immune cell infiltration expression, had a high predictive value immunotherapy efficacy. Mechanistically, competitively bound to miR-29c-3p unleash SIRT1's tumor-promoting function. SIRT1 inhibitor-EX527 were screened virtual screening verified vitro vivo assays. Notably, acetyltransferase P300-mediated super-enhancer activity stimulated transcription. Collectively, could be diagnostic prognostic biomarker. also biomarker Super-enhancer is driver overexpression cervical cancer gastric cancer.

Language: Английский

Citations

4
MYC and HSF1 Cooperate to Drive Sensitivity to Polo-like Kinase 1 Inhibitor Volasertib in High Grade Serous Ovarian Cancer DOI Creative Commons
Imade Williams,

Matthew R. O’Malley,

Haddie DeHart

et al.

Cancer Research Communications, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 20, 2025

Abstract Ovarian cancer is a deadly gynecological disease with frequent recurrence. Current treatments for patients include platinum-based therapy regimens PARP inhibitors specific HR-deficient high-grade serous ovarian cancers (HGSOCs). Despite initial effectiveness, inevitably develop progression as tumor cells acquire resistance. Toward the development of new therapeutic avenues, we describe gene amplification involving both HSF1 and MYC, wherein these two genes are co-amplified in over 30% HGSCO patients. We further found that MYC transcriptional activity was highly correlated human HGSOC tumors cell lines, suggesting they may cooperate disease. CUT&RUN revealed overlapping binding throughout genome. Moreover, peaks transcription factors were nearly identical, protein-protein interaction between detected, supporting molecular cooperation. Supporting functional cooperation factors, growth co-amplification dependent on MYC. To identify target could take advantage this unique dependency, polo-like kinase 1 (PLK1) specimens. Targeting PLK1 volasertib greater than 200-fold increased potency HSF1-MYC compared to those wild-type copy number. Although success other clinical trials has been modest, current study suggests targeting precision medicine approach using biomarker HGSOC.

Language: Английский

Citations

0
Enhancer reprogramming: critical roles in cancer and promising therapeutic strategies DOI Creative Commons
Jinshou Yang,

Feihan Zhou,

Xiyuan Luo

et al.

Cell Death Discovery, Journal Year: 2025, Volume and Issue: 11(1)

Published: March 3, 2025

Abstract Transcriptional dysregulation is a hallmark of cancer initiation and progression, driven by genetic epigenetic alterations. Enhancer reprogramming has emerged as pivotal driver carcinogenesis, with cells often relying on aberrant transcriptional programs. The advent high-throughput sequencing technologies provided critical insights into enhancer events their role in malignancy. While targeting enhancers presents promising therapeutic strategy, significant challenges remain. These include the off-target effects enhancer-targeting technologies, complexity redundancy networks, dynamic nature reprogramming, which may contribute to resistance. This review comprehensively encapsulates structural attributes enhancers, delineates mechanisms underlying malignant transformation, evaluates opportunities limitations associated cancer.

Language: Английский

Citations

0