Forum of Clinical Oncology, Journal Year: 2022, Volume and Issue: 13(1), P. 1 - 2
Published: Dec. 1, 2022
Language: Английский
Journal of Endocrinological Investigation, Journal Year: 2023, Volume and Issue: 47(1), P. 17 - 33
Published: Sept. 11, 2023
Abstract Purpose The purpose of this review is to examine the current evidence on potential role Mediterranean diet (MD) in prevention and management endocrine disorders highlight importance interdisciplinary collaboration between endocrinologists nutritionists. Methods A literature search was conducted using PubMed Google Scholar databases identify relevant studies published English. Studies were selected based their relevance MD disorders. terms included "Mediterranean diet," "endocrine disorders," "thyroid "gonadal "neuroendocrine tumors". Results reviewed suggest that may have a beneficial effect various disorders, including thyroid gonadal neuroendocrine tumors. has been associated with decreased risk nodular disease cancer, improved male female reproductive health, MD's anti-inflammatory antioxidant properties, as well its high levels phytochemicals, play effects. Conclusion Interdisciplinary nutritionists essential for optimal management. While further research needed, suggests protective against incorporation into dietary recommendations be beneficial.
Language: Английский
Citations
23
Endocrine, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 3, 2025
Language: Английский
Citations
0
Experimental Dermatology, Journal Year: 2025, Volume and Issue: 34(1)
Published: Jan. 1, 2025
ABSTRACT Merkel cell carcinoma (MCC) is a skin cancer that arises due to either polyomavirus infection (MCPyV) or ultraviolet (UV) radiation exposure, presenting primarily in the head and neck region of fair‐skinned males. The recent success PD‐(L)1 immune checkpoint inhibitors (ICIs) locally advanced/metastatic MCC, with an objective response rate (ORR) around 50% improved survival, as first‐line treatment has moved ICIs forefront therapy for MCC generated interest identifying biomarkers predict clinical response. tumour microenvironment (TME) contains various components adaptive innate system. These can contribute escape through immunosuppression by preventing entrance other cells aiding cytotoxic clearance cells. We aim combine information from studies baseline on‐treatment monitoring TME help MCC. This review enhances understanding how CD8 T cells, γδ macrophages may impact predictions rates patients. are non‐genetic also be used determine prognosis treatment.
Language: Английский
Citations
0
The Oncologist, Journal Year: 2025, Volume and Issue: 30(2)
Published: Feb. 1, 2025
Abstract Patients with advanced gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) have impaired nutritional and physical performance due to the cancer pathophysiology its treatment. The NUTRIGETNE study sought characterize status of patients GEP-NENs in Spain. This is a cross-sectional that included receiving active oncological had complete examination, anthropometry, bioelectrical impedance, dynamometry, laboratory analysis, comprehensive risk assessment. Malnutrition was defined according Global Leadership Initiative on (GLIM) criteria. 399 out 400 planned (Pearson’s χ2; α 0.05). Median age 62 years (22-83). Tumors most commonly originated small intestine (43.9%) pancreas (41.6%), 94.7% were metastatic, 36.7%, 49.4%, 12.5% G1, G2, G3, respectively. prevalence 61.9% (25.8% moderate; 36.1% severe), mainly low muscle mass (50.9%), which prevalent GLIM phenotypic Moreover, malnutrition showed correlation decreased hand grip strength (mean 23 vs 31.9 kg; P <.001) phase angle (median 5o 5.6o; <.001). sarcopenia 15%. more frequent diabetes (74.4% 56.7%; <.001), NECs (82.1% 60.3%; =.062), those treated chemotherapy (71.2% 59.7%; =.058), whereas it did not correlate tumor origin (P =.507), histological grade =.781), or functionality =.465). correlated body index (BMI) =.015), although also diagnosed high proportion no weight loss (63%, 54.1%, 65.1% normal BMI, overweight, obesity, respectively). Cachexia present 109 (27.3%) patients. very underdiagnosed GEP-NENs. It associated worse QoL, requiring multifactorial Certain factors such as presence may require closer monitoring higher malnutrition.
Language: Английский
Citations
0
Food and Agricultural Immunology, Journal Year: 2025, Volume and Issue: 36(1)
Published: April 17, 2025
Language: Английский
Citations
0
Journal of Endocrinological Investigation, Journal Year: 2025, Volume and Issue: unknown
Published: April 28, 2025
Language: Английский
Citations
0
Cancers, Journal Year: 2025, Volume and Issue: 17(9), P. 1593 - 1593
Published: May 7, 2025
Background: Neuroendocrine neoplasms (NENs) represent a heterogeneous group of malignancies that consist two major subtypes: neuroendocrine tumors (NETs) and carcinomas (NECs). Glucagon-like peptide-1 receptor agonists (GLP-1Ra) have demonstrated favorable results in preclinical studies, but their impact on NEN outcomes remains unexplored. Methods: Using the TriNetX US Research Network, we identified adult patients with either diabetes or obesity. After 1:1 propensity score matching based demographics, comorbidities, procedures, medication use, compared survival between who received GLP-1Ra after diagnosis those did not. Results: Among 32,464 eligible patients, 3139 29,325 matching, each cohort included 3043 well-balanced baseline characteristics. During follow-up periods extending up to 15 years, all-cause mortality occurred 356 (11.7%) users versus 753 (24.7%) non-users, representing 13.0% absolute risk reduction (p < 0.001). use was associated significantly improved (HR = 0.56, 95%CI 0.49–0.63, p Both well-differentiated 0.52) poorly differentiated 0.56) showed significant improvement. primary sites, lung NENs most pronounced benefit 0.42). Tirzepatide strongest association reduced 0.16), followed by semaglutide 0.27) dulaglutide 0.52). In this large propensity-matched study, 44.3% among The magnitude observed suggests potential role for as adjunctive therapy patient population. Prospective clinical trials are warranted confirm these findings explore underlying mechanisms.
Language: Английский
Citations
0
Obesity Facts, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 20
Published: Oct. 21, 2024
Obesity, a prevalent and multifactorial disease, is linked to range of metabolic abnormalities, including insulin resistance, dyslipidemia, chronic inflammation. These imbalances not only contribute cardiometabolic diseases but also play significant role in cancer pathogenesis. The rising prevalence obesity underscores the need investigate dietary strategies for effective weight management individuals with overweight or cancer. This European Society Study Obesity (EASO) position statement aimed summarize current evidence on provide insights major nutritional interventions, Mediterranean diet (MedDiet), ketogenic (KD), intermittent fasting (IF), that should be adopted manage MedDiet, characterized by high consumption plant-based foods moderate intake olive oil, fish, nuts, has been associated reduced risk. KD IF are emerging interventions potential benefits loss health. KD, inducing ketosis, IF, through periodic cycles, may offer anticancer effects modifying tumor metabolism improving sensitivity. Despite promising results, these approaches limited inconsistent, challenges variability adherence personalized plans.
Language: Английский
Citations
2
Journal of Endocrinological Investigation, Journal Year: 2024, Volume and Issue: 48(2), P. 269 - 281
Published: Oct. 12, 2024
Neuroendocrine neoplasms (NENs) represent heterogeneous tumors arising from neuroendocrine cells in different organs. Despite growing interest the nutritional aspects of NEN management, research this area is limited. Aim review to summarize current state knowledge, highlight gaps, and underscore significance nutrition comprehensive care patients. We conducted an extensive bibliographic search focusing on studies (including retrospective prospective studies, systematic reviews, case series, guidelines) exploring relationship between assessments, dietary interventions, micronutrient deficiencies, their impact outcomes. Significant gaps exist research, particularly understanding specific needs patients how tailored interventions can improve clinical Evidence suggests that a high-fat Western diet may promote growth NEN, while Mediterranean help lower insulin levels strengthen immune system, potentially preventing tumor development. The ketogenic intermittent fasting also have positive impacts. Addressing common such as vitamin D niacin, crucial mitigate disease progression. There's need for future include assessment incorporating patient-reported outcomes, fully capture strategies. Nutritional important but under-researched facet treatment, significantly improves patients' quality life survival. Integrating into personalized cancer essential, highlighting role strategies optimizing patient
Language: Английский
Citations
1
Reviews in Endocrine and Metabolic Disorders, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 9, 2024
Language: Английский
Citations
1