Seminars in Oncology Nursing, Journal Year: 2024, Volume and Issue: unknown, P. 151793 - 151793
Published: Dec. 1, 2024
Language: Английский
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2025, Volume and Issue: unknown, P. 189322 - 189322
Published: April 1, 2025
Language: Английский
Citations
0
Published: April 20, 2025
Aim: Fructose is a highly lipogenic compound related to the onset of steatosis, its progression steatohepatitis, and eventual initiation hepatocellular carcinoma (HCC). One cancer hallmarks metabolic adaptation environmental sources; however, this characteristic could be exploited manipulate HCC tumor’s response therapies. Due high prevalence in consumption diets enriched with fructose unclear results literature, it pertinent characterize effects on biology as possible beneficial player aggressiveness cancer. We focused investigating effect liver cells chemotherapy response. Methods: treated Huh-7 HepG2 cell lines 1 mM address reprogramming fructose-induced effects. Results: Cancer use an alternative fuel source glucose-starved conditions, ensuring tumorigenic properties survival both lines. The differed depending line origin aggressiveness. Conclusions: showed under treatment, enhancing pentose phosphate pathway anabolism. Metabolic rewiring also improves chemoresistance vitro vivo, contributing failure cells.
Language: Английский
Citations
0
Immunology, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 27, 2024
ABSTRACT Cancer is a complex and heterogeneous disease characterised by uncontrolled cell growth proliferation. One hallmark of cancer cells their ability to undergo metabolic reprogramming, which allows them sustain rapid survival. This reprogramming creates an immunosuppressive microenvironment that facilitates tumour progression evasion the immune system. In this article, we review mechanisms underlying in discuss how these alterations contribute establishment microenvironment. We also explore potential therapeutic strategies targeting vulnerabilities enhance immune‐mediated anti‐tumour responses. Trial Registration ClinicalTrials.gov identifier: NCT02044861, NCT03163667, NCT04265534, NCT02071927, NCT02903914, NCT03314935, NCT03361228, NCT03048500, NCT03311308, NCT03800602, NCT04414540, NCT02771626, NCT03994744, NCT03229278, NCT04899921
Language: Английский
Citations
2
Actas Dermo-Sifiliográficas, Journal Year: 2023, Volume and Issue: 115(4), P. 374 - 386
Published: Oct. 25, 2023
Numerous diets for losing weight, building strength, and managing a range of cardiovascular, neurologic, skin diseases have become popular in recent years. The ketogenic diet intermittent fasting particular shown promising results clinical sports medicine. Mediterranean diet, turn, is widely recognized its numerous health benefits. Also are the paleo vegan gluten-free diets. Positive effects on inflammatory conditions, such as psoriasis, atopic dermatitis, hidradenitis suppurativa, acne, been observed patients who practice or follow This last choice may also protect against certain cancers. We review role several management disorders. Se han popularizado diversas dietas para perder peso, incrementar la capacidad física y el manejo de múltiples patologías crónicas: cardiovasculares, neurológicas o cutáneas. Destacan dieta cetogénica ayuno intermitente, con resultados prometedores en medicina tradicional deportiva. Además, mediterránea se ha consolidado como una forma alimentación impacto positivo muy significativo salud. Otras populares son "paleo", vegana libre gluten. La cetogénica, intermitente aportan favorables dermatosis inflamatorias dermatitis atópica, supurativa y/o acné. podría actuar también factor protector desarrollo algunas neoplasias En este artículo presentamos revisión del rol dermatosis.
Citations
5
Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(18), P. 6018 - 6018
Published: Sept. 17, 2023
An improved recognition of inborn errors immunity (IEI) is associated with an increase in life expectancy and a higher incidence complications related conditions. The aim the study was to analyze factors enabling primary prevention: BMI, smoking selected laboratory tests (morphology smear, creatinine, eGFR, total protein, albumin, ferritin, folic acid, vitamin B12, D3) included protocols standard care for adult patients antibody deficiencies (PADs). 94 participants ≥ 18 years old, diagnosed PADs. Overweight found 17%, obesity 14% underweight 15% patients; 11.5% smoked. Leukopenia 16%, neutropenia 8.5%, lymphopenia 22.5% thrombocytopenia patients. A decreased concentration hemoglobin 32%, protein 19%, albumin D3 52%, B12 6.5%, acid 34% ferritin 26% Creatinine concentrations were elevated 16% patients, while 20%, eGFR reduced. Only holistic assessment comorbidities deficiency, as well regular follow-up lifestyle changes, can yield best results long-term
Language: Английский
Citations
4
Actas Dermo-Sifiliográficas, Journal Year: 2024, Volume and Issue: 115(4), P. T374 - T386
Published: Feb. 7, 2024
Numerous diets for losing weight, building strength, and managing a range of cardiovascular, neurologic, skin diseases have become popular in recent years. The ketogenic diet intermittent fasting particular shown promising results clinical sports medicine. Mediterranean diet, turn, is widely recognized its numerous health benefits. Also are the paleo vegan gluten-free diets. Positive effects on inflammatory conditions, such as psoriasis, atopic dermatitis, hidradenitis suppurativa, acne, been observed patients who practice or follow This last choice may also protect against certain cancers. We review role several management disorders.
Language: Английский
Citations
1
Nutrients, Journal Year: 2024, Volume and Issue: 16(4), P. 477 - 477
Published: Feb. 7, 2024
This study assesses the feasibility of calorie restriction (CR) and time-restricted feeding (TRF) in overweight obese cancer patients who realized little to no physical activity undergoing curative radiotherapy, structured as a prospective, interventional, non-randomized open-label clinical trial. Of 27 participants initially enrolled, 21 with breast were selected for analysis. The self-selected into two dietary interventions: TRF, comprising sugar saturated fat-free diet calibrated individual energy needs consumed within an 8 h eating window followed by 16 fast, or CR, involving 25% reduction total caloric intake from expenditure distributed across 4 meals 1 snack 55% carbohydrates, 15% protein, 30% fats, excluding sugars fats. primary goal was evaluate these diets specific patient group. results indicate that both interventions are effective statistically significant weight loss reducing one’s waist circumference, TRF showing potentially stronger impact better adherence. Changes LDL, HDL, cholesterol, triglycerides, glucose insulin not significant.
Language: Английский
Citations
1
Published: June 24, 2024
Epithelial ovarian cancer significantly contributes to cancer-related mortality in women, often recurring post-treatment with chemotherapy resistance. Dietary interventions have demonstrated influence on progression; for instance, caloric restriction has exhibited tumor growth reduction and enhanced survival animal models. This study aims calculate a transcriptomic signature based caloric-restriction patients explore its correlation disease progression. We identified proteins modulated by fasting, intermittent fasting or human females. Based their gene expression, we calculated Non-Fasting Genomic Signature score samples from the TCGA database. examined association between this genomic profile clinical characteristics. The non-fasting signature, comprising eight genes, higher prevalence primary tumors compared normal tissue. Patients elevated expression reduced overall increased lymphatic invasion. mesenchymal subtype, associated resistance, displayed highest expression. Multivariate analysis suggested as potential independent prognostic factor. Ovarian expressing “non-fasting” transcriptional correlate poorer outcomes, emphasizing impact of improving patient treatment response. Further investigations, including trials, are warranted validate these findings.
Language: Английский
Citations
1
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: Sept. 9, 2024
The burgeoning field of pharmacomicrobiomics offers promising insights into the intricate interplay between microbiome and cancer, shaping responses to diverse treatment modalities. This review aims analyze molecular mechanisms underlying interactions distinct microbiota types as well their influence on outcomes. We explore how impacts antitumor immunity, response chemotherapy, immunotherapy, radiation therapy, unveiling its multifaceted roles in cancer progression therapy resistance. Moreover, we discuss challenges hindering development microbiome-based interventions including standardization, validation, clinical translation. By synthesizing evidence, underscore transformative potential harnessing guiding decisions, paving way for improved patient outcomes practice.
Language: Английский
Citations
1
Nutrition and Cancer, Journal Year: 2024, Volume and Issue: 77(1), P. 26 - 50
Published: Sept. 28, 2024
Radiotherapy is a common cancer treatment, and concurrent nutritional interventions can maintain status improve clinical supportive care outcomes. However, optimal during radiotherapy are not firmly established. Herein, we assessed the feasibility, safety, efficacy of dietary counseling without oral nutrition supplements on health outcomes in adults receiving for systematic review. Prospective trials that implemented were identified from four databases inception through December 2023. Feasibility, extracted 32 articles described 23 randomized 4 non-randomized trials. The included individualized (
Language: Английский
Citations
1