Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Dec. 23, 2024
Abstract
In
pathological
examinations,
gastric
ulcers
are
often
detected
in
South
American
camelids.
The
aetiology
cannot
be
clarified
every
case.
However,
tumour-related
observed
repeatedly.
This
study
reports
clinical,
laboratory
and
findings
six
alpacas,
three
each
with
adenocarcinoma-
squamous
cell
carcinoma-associated
ulcers.
Clinically
they
were
presented
general
symptoms
like
emaciation,
anorexia
recumbency.
Laboratory
of
these
animals
non-specific.
All
at
least
nine
years
old.
adenocarcinomas
as
well
the
carcinomas
metastasised
various
organs,
especially
lymph
nodes.
Two
adenocarcinoma-associated
perforated.
summary,
can
lead
to
ulcerative
lesions
gastrointestinal
tract.
Although
neoplasms
rare
overall,
should
considered
a
possible
differential
diagnosis
case
non-specific
symptoms.
particular,
older
seem
affected
more
frequently.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(5), P. 2798 - 2798
Published: Feb. 28, 2024
Oropharyngeal
squamous
cell
carcinoma
(OPSCC),
a
subset
of
head
and
neck
(HNSCC),
involves
the
palatine
tonsils,
soft
palate,
base
tongue,
uvula,
with
ability
to
spread
adjacent
subsites.
Personalized
treatment
strategies
for
Human
Papillomavirus-associated
oropharynx
(HPV+OPSCC)
are
yet
be
established.
In
this
article,
we
summarise
our
current
understanding
pathogenesis
HPV+OPSCC,
intrinsic
role
immune
system,
ICI
clinical
trials,
potential
small
molecule
immunotherapy
in
HPV+OPSCC.
Cancers,
Journal Year:
2024,
Volume and Issue:
16(5), P. 1044 - 1044
Published: March 4, 2024
With
the
ongoing
progress
of
basic
research
along
with
introduction
new
pharmaceutical
options
spanning
almost
all
therapeutic
areas,
need
for
biomarkers
that
will
be
implemented
into
personalized
medical
approach
is
higher
than
ever.
Their
use
can
incorporated
clinical
practice
and
applied
to
classification
disorders
evaluation
disease
severity
but
also
monitoring
therapeutic/pharmaceutical
interventions.
This
systematic
review
collects
findings
hematologic
in
various
cutaneous
malignancies,
excluding
malignant
melanoma,
support
their
potential
prognosis
assessment
strategies
specific
category
skin
disorders.
Vaccines,
Journal Year:
2023,
Volume and Issue:
11(8), P. 1354 - 1354
Published: Aug. 11, 2023
The
understanding
of
the
relationship
between
immunological
responses
and
cancers,
especially
those
related
to
HPV,
has
allowed
for
study
development
therapeutic
vaccines
against
these
neoplasias.
There
is
a
growing
number
studies
about
composition
influence
tumor
microenvironment
(TME)
in
progression
or
establishment
most
varied
types
cancer.
Hence,
it
been
possible
structure
immunotherapy
approaches
based
on
that
are
even
more
specific
directed
components
TME
immune
response
associated
with
tumors.
Among
dendritic
cells
(DCs),
which
main
professional
antigen-presenting
(APCs)
already
studied
therapy
strategies
HPV-related
cancers.
On
other
hand,
tumor-associated
macrophages
also
potential
targets
since
profile
present
infiltrates,
M1
M2,
influences
prognosis
some
These
two
cell
can
be
immunomodulation.
In
this
context,
our
review
aims
provide
an
overview
HPV-positive
tumors,
such
as
cervical
head
neck
pointing
promising
approaches.
This
explores
cancer
treatment,
including
checkpoint
inhibitors,
cytokine
immunotherapies,
vaccines,
therapies.
Furthermore,
highlights
importance
its
effect
design
achievement
immunotherapeutic
methods.
Journal of Clinical Investigation,
Journal Year:
2025,
Volume and Issue:
135(8)
Published: April 14, 2025
HNSCC
remains
a
substantial
health
issue,
with
treatment
options
including
surgery,
radiation,
and
platinum-based
chemotherapy.
Unfortunately,
despite
progress
in
research,
only
modest
gains
have
been
made
disease
control,
existing
treatments
resulting
significant
functional
quality-of-life
issues.
The
introduction
of
immunotherapy
the
has
resulted
some
improvements
outlook
for
patients
is
now
standard
care
populations
both
recurrent
metastatic
disease.
However,
early
successes,
responses
to
immune
checkpoint
inhibition
(ICI)
remain
low,
approaching
14%-22%
objective
response
rates.
Challenges
effectiveness
ICI
other
immunotherapies
are
complex,
diverse
dynamic
molecular
plasticity
heterogeneity
HNSCCs;
lack
immunogenic
antigens;
accumulated
suppressive
such
as
myeloid
cells
dysfunctional
T
cells;
nutrient
depletion;
metabolic
dysregulation
tumor
microenvironment.
In
this
Review,
we
explore
mechanisms
responsible
resistance,
dissect
these
challenges,
discuss
potential
opportunities
overcoming
hurdles
development
successful
HNSCC.
OTO Open,
Journal Year:
2025,
Volume and Issue:
9(2)
Published: April 1, 2025
Abstract
Circulating
tumor
DNA
(ctDNA)
has
been
developed
as
a
marker
of
burden
in
human
papillomavirus
(HPV)‐positive
oropharyngeal
squamous
cell
carcinoma
(OPSCC).
Inflammatory
indices
are
also
increasingly
being
used
prognostic
surrogate
markers
solid
tumors,
including
head
and
neck
cancers.
The
relationship
between
ctDNA
levels
inflammatory
not
studied
HPV‐associated
OPSCC.
We
hypothesize
that
higher
inflammation
associated
with
levels.
Herein,
we
demonstrate
an
association
high
pretreatment
specific
indices,
which
may
be
lower‐cost
HPV
act
for
the
body's
immune
response
to
HPV‐positive
Diagnostics,
Journal Year:
2023,
Volume and Issue:
13(22), P. 3396 - 3396
Published: Nov. 7, 2023
Introduction:
Neutrophil-to-lymphocyte
ratio
(NLR),
lymphocyte-to-monocyte
(LMR),
and
pallets-to-lymphocyte
(PLR)
are
currently
validated
as
cheap
accessible
biomarkers
in
different
types
of
solid
tumors,
including
head
neck
cancers
(HNC).
The
purpose
the
study:
To
evaluate
possible
purposes
biomarker
value
NLR,
PLR,
MLR
recorded
pre-treatment
(radiotherapy/chemotherapy)
HNC.
Materials
methods:
From
190
patients
with
HNC
included
oncology
records
outpatient
clinic
Craiova
County
Emergency
Hospital
(from
January
2002
to
December
2022),
39
cases
met
inclusion
criteria
(squamous
cell
carcinoma
possibility
calculate
(chemotherapy/radiotherapy)
MLR.
Overall
survival
(OS)
values
were
correlated
Results:
median
for
6.15
(1.24–69),
200.79
(61.3–1775.0),
0.53
(0.12–5.5),
respectively.
In
study,
mean
2.88,
142.97,
0.36,
respectively,
obtained.
OS
study
group
was
11
months
(1–120).
Although
a
negative
Pearson’s
correlation
present,
relationship
between
variables
only
weak,
R
=
0.07,
p
0.67,
0.02,
0.31,
0.62
being
related
MLR,
OS.
calculated
(1.53,
90.32,
0.18,
respectively)
NLR
<
2
≥
6
(23.5,
232.78,
0.79,
respectively).
17.4
13
months,
Conclusions:
comparative
analysis
data
highlights
benefit
low
NLR.
role
not
borderline
(between
6)
prognostic
marker
HNSCC
but
also
PLR
score
must
be
defined
future.
Prospective
studies
more
uniformly
selected
could
demonstrate
treatment
stratification
through
intensification
or
de-escalation
non-surgical
curative
HNSCC.
Angiology,
Journal Year:
2023,
Volume and Issue:
75(8), P. 786 - 795
Published: Aug. 16, 2023
The
present
study
aimed
to
explore
the
association
between
neutrophil-to-lymphocyte
ratio
(NLR)
and
prognosis
of
critically
ill
chronic
heart
failure
patients.
records
5298
patients
who
met
inclusion
criteria
were
extracted
from
Medical
Information
Mart
for
Intensive
Care
IV
database.
primary
outcome
was
30-days
all-cause
mortality
secondary
90-days
mortality.
Multivariable
logistic
regression
analysis
performed
examine
relationship
NLR
Subgroup
carried
out
identify
whether
differed
across
various
subgroups.
For
mortality,
after
adjusting
multiple
confounders,
odds
(OR)
(95%
confidence
interval
[CI])
second
(NLR
4.0–8.4)
third
≥8.4)
tertiles
1.52
(1.13–2.03)
2.53
(1.92–3.34),
respectively,
compared
with
first
tertile
<4.0).
As
OR
1.34
(1.07–1.67)
2.23
(1.81–2.76)
reference
(NLR<4.0).
interactions
sepsis
subgroup
significant.
Our
concluded
that
an
independent
predictor
30-
failure.
