The Egyptian Journal of Radiology and Nuclear Medicine,
Journal Year:
2024,
Volume and Issue:
55(1)
Published: Nov. 29, 2024
Abstract
Background
Breast
cancer
is
one
of
the
most
common
cancers
among
female
population
globally
and
a
major
cause
death
due
to
women.
It
has
been
classified
into
histopathological,
hormonal,
molecular
subtypes
based
on
hormone
receptor
status.
Their
management
involves
multidisciplinary
approach
depending
these
subtypes,
TNM
staging,
tumour
size,
site.
The
purpose
this
study
was
assess
correlation
between
ultrasound
mammography
characteristics
maximum
standardized
uptake
value
PET
with
hormonal
breast
cancer.
Methods
retrospective
from
single-centre
data
available
for
8
months.
In
study,
5
were
considered;
Luminal
A,
B,
HER2-positive
subtype,
HER2-enriched
triple-negative
subtype.
morphology
lesions
analysed
sonography
SUV
max
considered
analyses.
prediction
performance
features
then
analysed.
Results
A
B
had
indistinct
margins
posterior
acoustic
shadowing
ultrasound.
Triple-negative
well-circumscribed
enhancement
characteristically
pleomorphic
microcalcifications
mixed
mammography.
On
PET,
cases
highest
SUV,
subtype
lowest
SUV.
Conclusion
According
our
observations,
there
are
certain
typical
morphological
imaging
each
These
modalities
may
help
radiologists
clinicians
in
stratifying
their
patients
prognostication
better
management.
World Journal of Nuclear Medicine,
Journal Year:
2024,
Volume and Issue:
23(03), P. 217 - 219
Published: June 14, 2024
Abstract
Gallium-68
(68Ga)-fibroblast
activation
protein
inhibitor
(FAPI)
positron
emission
tomography
(PET)
images
the
cancer-associated
fibroblast
that
forms
a
vital
component
of
tumor
microenvironment.
It
is
known
68Ga-FAPI
PET
can
aid
in
differentiating
reactive
lymph
nodes
from
metastatic
nodes.
18F-fluorodeoxyglucose
(FDG)
PET/computed
(CT)
still
most
commonly
used
radiopharmaceutical
evaluation
wide
range
malignancies
including
breast
carcinoma.
Reactive
may
also
show
FDG
uptake
which
hinder
optimal
assessment
for
involvement.
We
report
an
interesting
case
invasive
ductal
carcinoma
right
with
associated
World
Health
Organization
clinical
stage
I
acquired
immunodeficiency
syndrome
18F-FDG
PET/CT
and
were
done.
iScience,
Journal Year:
2024,
Volume and Issue:
27(12), P. 111368 - 111368
Published: Nov. 13, 2024
Fibroblast
activation
protein
(FAP)
is
highly
expressed
in
solid
tumors
and
may
be
a
potential
diagnostic
therapeutic
target
cancers.
Linagliptin
inhibits
FAP;
however,
the
interaction
mechanism
between
linagliptin
FAP
remains
unclear.
In
this
study,
binding
free
energy
for
with
human
was
estimated
at
-13.66
kcal/mol,
dissociation
constant
243
nM
based
on
surface
plasmon
resonance
analyses.
E203,
E204,
Y656
formed
hydrogen
bonds
ammonium.
Y625
an
unstable
bond
carbonyl
group.
W623
Y541
interacted
quinazoline
pyrimidine-2,4-dione
rings,
respectively,
via
π-π
interactions.
The
butyne
group
hydrophobic
interactions
residues
V650,
Y653,
Y656,
Y660.
ZINC000299754517
ZINC000299754576
were
identified
as
inhibitors.
R1
R4
regions
of
could
optimized
to
increase
its
affinity.
These
findings
can
guide
structural
optimization
improve
Analytical Methods,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 15, 2024
This
paper
combines
SPM,
M_D-FA,
and
DLNM
to
improve
multi-spectral
image
quality
classify
heterogeneities.
Results
show
significant
accuracy
enhancements,
achieving
95.47%
with
VGG19
98.47%
ResNet101
in
breast
tumor
screening.
The Egyptian Journal of Radiology and Nuclear Medicine,
Journal Year:
2024,
Volume and Issue:
55(1)
Published: Nov. 29, 2024
Abstract
Background
Breast
cancer
is
one
of
the
most
common
cancers
among
female
population
globally
and
a
major
cause
death
due
to
women.
It
has
been
classified
into
histopathological,
hormonal,
molecular
subtypes
based
on
hormone
receptor
status.
Their
management
involves
multidisciplinary
approach
depending
these
subtypes,
TNM
staging,
tumour
size,
site.
The
purpose
this
study
was
assess
correlation
between
ultrasound
mammography
characteristics
maximum
standardized
uptake
value
PET
with
hormonal
breast
cancer.
Methods
retrospective
from
single-centre
data
available
for
8
months.
In
study,
5
were
considered;
Luminal
A,
B,
HER2-positive
subtype,
HER2-enriched
triple-negative
subtype.
morphology
lesions
analysed
sonography
SUV
max
considered
analyses.
prediction
performance
features
then
analysed.
Results
A
B
had
indistinct
margins
posterior
acoustic
shadowing
ultrasound.
Triple-negative
well-circumscribed
enhancement
characteristically
pleomorphic
microcalcifications
mixed
mammography.
On
PET,
cases
highest
SUV,
subtype
lowest
SUV.
Conclusion
According
our
observations,
there
are
certain
typical
morphological
imaging
each
These
modalities
may
help
radiologists
clinicians
in
stratifying
their
patients
prognostication
better
management.
