Cancers,
Journal Year:
2023,
Volume and Issue:
15(16), P. 4143 - 4143
Published: Aug. 17, 2023
In
this
editorial
context,
we
aim
to
leverage
the
potential
of
proteogenomics,
which
integrates
genomic
and
proteomic
data,
discover
novel
biomarkers
that
can
aid
in
diagnosis
management
prostate
cancer.
We
highlight
importance
proteogenomics
for
understanding
functional
consequences
somatic
mutations
cancer
demonstrating
how
proteogenomic
analysis
provide
insights
into
effects
genetic
alterations
on
landscape
identify
therapeutic
targets.
This
article
also
emphasizes
urine
detection
Overall,
our
paper
provides
general
application
identification
Journal of Cancer Research and Clinical Oncology,
Journal Year:
2024,
Volume and Issue:
150(10)
Published: Oct. 16, 2024
Prostate
cancer
(PCa)
is
the
most
prevalent
malignancy
and
second
leading
cause
of
cancer-related
deaths
among
men.
While
adenocarcinoma
prostate
(adeno-PCa)
well-characterized,
neuroendocrine
(NEPC)
remains
poorly
understood.
Generally,
NEPC
a
rare
but
highly
aggressive
histological
variant,
however
its
limited
patho-physiological
understanding
leads
to
insufficient
treatment
options
associated
with
low
survival
rates
for
patients.
Current
treatments
NEPC,
including
platinum-based
therapies,
offer
some
efficacy,
there
significant
need
more
targeted
approaches.
This
review
summarizes
molecular
characteristics
in
contrast
adeno-PCa,
providing
comprehensive
comparison.
A
portion
discussion
dedicated
tumor
microenvironment
(TME),
which
has
recently
been
identified
as
key
factor
progression.
The
TME
includes
various
cells,
signaling
molecules,
extracellular
matrix
surrounding
tumor,
all
play
critical
roles
development
response
treatment.
Understanding
TME's
influence
on
could
uncover
new
avenues
innovative
strategies,
potentially
improving
outcomes
patients
this
challenging
variant
PCa.
Cancers,
Journal Year:
2023,
Volume and Issue:
15(16), P. 4143 - 4143
Published: Aug. 17, 2023
In
this
editorial
context,
we
aim
to
leverage
the
potential
of
proteogenomics,
which
integrates
genomic
and
proteomic
data,
discover
novel
biomarkers
that
can
aid
in
diagnosis
management
prostate
cancer.
We
highlight
importance
proteogenomics
for
understanding
functional
consequences
somatic
mutations
cancer
demonstrating
how
proteogenomic
analysis
provide
insights
into
effects
genetic
alterations
on
landscape
identify
therapeutic
targets.
This
article
also
emphasizes
urine
detection
Overall,
our
paper
provides
general
application
identification
