Metastatic Myoepithelial Carcinoma Ex Pleomorphic Adenoma of the Sublingual Salivary Gland DOI Open Access

Ângela Ferreira,

Joana Carla Soares Gonçalves, Andréia de Assis Ferreira

et al.

Cureus, Journal Year: 2023, Volume and Issue: unknown

Published: June 3, 2023

Myoepithelial carcinoma ex pleomorphic adenoma is a very rare malignant neoplasm of the salivary gland. Owing to its rarity, clinical features and treatment are not well characterized. We describe case patient who was referred our department with six-month history bulge on right side floor mouth submandibular mass progressive enlargement. The resected, an elective level I neck dissection performed. Histological examination revealed myoepithelial sublingual Thoracic computed tomography biopsy lung metastases. died two years after diagnosis.

Language: Английский

Current Developments in Diagnosis of Salivary Gland Tumors: From Structure to Artificial Intelligence DOI Creative Commons
Alexandra Corina Faur, Roxana Buzaș, Adrian Emil Lăzărescu

et al.

Life, Journal Year: 2024, Volume and Issue: 14(6), P. 727 - 727

Published: June 5, 2024

Salivary glands tumors are uncommon neoplasms with variable incidence, heterogenous histologies and unpredictable biological behaviour. Most located in the parotid gland. Benign salivary represent 54–79% of cases pleomorphic adenoma is frequently diagnosed this group. malignant that more commonly adenoid cystic carcinomas mucoepidermoid carcinomas. Because their diversity overlapping features, these require complex methods evaluation. Diagnostic procedures include imaging techniques combined clinical examination, fine needle aspiration histopathological investigation excised specimens. This narrative review describes advances diagnosis unusual tumors—from histomorphology to artificial intelligence algorithms.

Language: Английский

Citations

6
Machine learning-based survival prediction nomogram for postoperative parotid mucoepidermoid carcinoma DOI Creative Commons
Zongwei Huang, Zihan Chen, Ying Li

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: April 1, 2024

Abstract Parotid mucoepidermoid carcinoma (P-MEC) is a significant histopathological subtype of salivary gland cancer with inherent heterogeneity and complexity. Existing clinical models inadequately offer personalized treatment options for patients. In response, we assessed the efficacy four machine learning algorithms vis-à-vis traditional analysis in forecasting overall survival (OS) P-MEC Using SEER database, analyzed data from 882 postoperative patients (stages I–IVA). Single-factor Cox regression techniques (random forest, LASSO, XGBoost, best subset regression) were employed variable selection. The optimal model was derived via stepwise backward regression, Akaike Information Criterion (AIC), Area Under Curve (AUC). Bootstrap resampling facilitated internal validation, while prediction accuracy gauged through C-index, time-dependent ROC curve, calibration curve. model’s relevance ascertained using decision curve (DCA). study found 3-, 5-, 10-year OS rates 0.887, 0.841, 0.753, respectively. BSR, LASSO stood out predictive efficacy, identifying seven key prognostic factors including age, pathological grade, T stage, N radiation therapy, chemotherapy, marital status. A subsequent nomogram revealed C-index 0.8499 (3-year), 0.8557 (5-year), 0.8375 (10-year) AUC values 0.8670, 0.8879, 0.8767, also highlighted significance radiotherapy across varying risk levels. Our model, grounded learning, surpasses superior visualization importance.

Language: Английский

Citations

5
Application of the Milan system for reporting salivary gland cytopathology to core needle biopsies of the parotid gland DOI
Anna‐Karoline Israel, Christopher C. Griffith

Histopathology, Journal Year: 2024, Volume and Issue: 85(2), P. 285 - 294

Published: May 21, 2024

The Milan system for reporting salivary gland cytopathology was developed by an international group of experts and first published in 2018 with the goal to standardise aspirates. Seven categories distinct risks malignancy were proposed. Core needle biopsies (CNB) glands are also common, but lacks standardisation. Here we explore feasibility a Milan-like on CNB parotid gland.

Language: Английский

Citations

2
The Epigenesis of Salivary Glands Carcinoma: From Field Cancerization to Carcinogenesis DOI Open Access
Norhafiza Mat Lazim, Anam Yousaf, Mai Abdel Haleem Abusalah

et al.

Cancers, Journal Year: 2023, Volume and Issue: 15(7), P. 2111 - 2111

Published: March 31, 2023

Salivary gland carcinomas (SGCs) are a diverse collection of malignant tumors with marked differences in biological activity, clinical presentation and microscopic appearance. Although the etiology is varied, secondary radiation, oncogenic viruses as well chromosomal rearrangements have all been linked to formation SGCs. Epigenetic modifications may also contribute genesis progression any heritable changes gene expression that not caused by DNA sequence. It now widely accepted epigenetics plays an important role SGCs development. A basic epigenetic process has variety pathological physiological conditions including cancer formation, methylation. Transcriptional repression CpG islands hypermethylation at promoters, whereas hypomethylation causes overexpression gene. identified, they genesis, prognosis these neoplasms. Thus, we conduct thorough evaluation currently known evidence on involvement processes

Language: Английский

Citations

6
Prognostic Significance of Histopathological Parameters for Salivary Gland Adenoid Cystic Carcinoma DOI Creative Commons
Éverton Freitas de Morais, Hannah Gil de Farias Morais, Roseana de Almeida Freitas

et al.

Dentistry Journal, Journal Year: 2023, Volume and Issue: 11(11), P. 262 - 262

Published: Nov. 9, 2023

Adenoid cystic carcinoma (ACC) is a rare salivary gland tumor that accounts for approximately 1% of all head and neck cancers. Despite its initial indolent behavior, long-term survival poor due to locoregional recurrence in 40% distant metastasis up 60% patients who undergo radical treatment. The histological parameters ACC the combination these histopathological grading systems provide valuable prognostic information about clinical course disease. Within this context, review aims analyze impact parameters, individual or combined malignancy, on prognosis. Individual such as solid pattern, presence necrosis, high-grade transformation, dominance epithelial component, perineural lymphovascular invasion, positive surgical margins have negative impacts with ACC. There are currently four ACC; however, few studies validated most them explored small cohorts short follow-up. Considering application has been associated prognosis, broader validation will allow not only their use prediction but also assist treatment planning.

Language: Английский

Citations

5
Role of Histone Deacetylases in the Pathogenesis of Salivary Gland Tumors and Therapeutic Targeting Options DOI Open Access
Maria Manou, Dimitrios S. Kanakoglou,

Theodoros Loupis

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(12), P. 10038 - 10038

Published: June 12, 2023

Salivary gland tumors (SGTs) comprise a rare and heterogenous category of benign/malignant neoplasms with progressively increasing knowledge the molecular mechanisms underpinning their pathogenesis, poor prognosis, therapeutic treatment efficacy. Emerging data are pointing toward an interplay genetic epigenetic factors contributing to heterogeneity diverse clinical phenotypes. Post-translational histone modifications such as acetylation/deacetylation have been shown actively participate in pathobiology SGTs, further suggesting that deacetylating (HDACs), selective or pan-HDAC inhibitors (HDACis), might present effective options for these neoplasms. Herein, we describe underlying pathology different types focusing on effects gene expression well progress HDACis SGT therapy current status relevant trials.

Language: Английский

Citations

4
Effectiveness and risk of second primary malignancies after radiotherapy in major salivary gland carcinomas: A retrospective study using SEER database DOI
Yuan Feng, Kai Qian, Kai Guo

et al.

Head & Neck, Journal Year: 2024, Volume and Issue: 46(5), P. 1201 - 1209

Published: Jan. 29, 2024

Abstract Objective To investigate the effectiveness of radiotherapy and its association with second primary malignancies (SPMs) risk in major salivary gland carcinomas (MSGCs) patients. Methods Cohort 1 included 7274 surgically treated MSGC patients from Surveillance, Epidemiology, End Results database, assessing radiotherapy. 2 ( n = 4213) comprised ≥5‐year survival to study SPMs. Radiotherapy decreased overall MSGCs patients, but improved it high‐grade MSGCs. Cumulative SPMs incidences at 25 years were 16.5% (RT) group compared 14.5% non‐radiotherapy (NRT) group. For head neck (SHNCs), 3.4% RT versus 1.6% NRT. increased relative risks tumors, particularly SHNCs (RR 1.78). The 10‐year OS rates after significantly lower. Conclusion improves advanced‐stage increases developing SPMs, SHNCs.

Language: Английский

Citations

1
Clinical pathological features and radiotherapy treatment for adenoid cystic carcinoma of the head and neck DOI Creative Commons

Gabriel Maluf,

Alberto Domingues Vianna,

Maria Graziela Kenupp

et al.

International Healthcare Review (online), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 11, 2024

Adenoid Cystic Carcinoma (ACC) is a slow-growing, locally invasive malignant tumour, with deceptively benign histological appearance, high probability of local recurrence and distant metastasis. The tumour comprises basaloid cells small, angular hyperchromatic nuclei scarce cytoplasm arranged into three significant prognostic patterns: cribriform, tubular, solid. In some tumours, dedifferentiation to high-grade form occurs. authors have reviewed numerous studies which attempted demonstrate accurate features, but these often produced conflicting results. literature review suggests that Analysis microarray gene expression profiles provided new potential diagnostic markers. However, tumor grade, lymph node metastasis, invasion major nerves, resection margin status continue be the most consistent predictors prognosis. optimal treatment ACC has not yet been fully established, although advocate using surgical excision postoperative radiotherapy. Careful staging grading documentation perineural remain important tools. incurable, patients will eventually succumb recurrence, or both. clinical course disease can surprisingly heterogeneous, surviving decades others only months. combination surgery radiotherapy in period shown best locoregional control. Contribution Evidence-Based healthcare: This contributes better understanding diagnosed cystic adenocarcinoma head neck, regard curative radiotherapy, as part proposed even reduce effects disease.

Language: Английский

Citations

1
Mutational Signatures in Salivary Gland Carcinomas DOI Open Access
Aristeidis Chrysovergis, Vasileios Papanikolaou, Despοina Spyropoulou

et al.

Cancer Diagnosis & Prognosis, Journal Year: 2023, Volume and Issue: 3(4), P. 411 - 415

Published: July 3, 2023

Salivary gland carcinomas belong to the head and neck carcinoma super category of malignancies. They are characterized by histopathological diversity comprise a variety entities subtypes. Mucoepidermoid, adenoid cystic salivary duct represent most prominent Concerning their corresponding genetic background, broad spectrum gene chromosomal imbalances has been detected. Point mutations deletions, amplifications translocations, combined or not with aneuploidy/polysomy/monosomy, create landscape specific signatures that affect biological behavior these tumors modify response rates potential targeted therapeutic strategies. In current molecular review, we focused on categorization description important mutational in carcinomas.

Language: Английский

Citations

2
A retrospective study of nonneoplastic and neoplastic disorders of the salivary glands DOI Creative Commons

Sorin Vameşu,

Oana Andreea Ursica,

Ana – Maria Gurita

et al.

Medicine, Journal Year: 2023, Volume and Issue: 102(42), P. e35751 - e35751

Published: Oct. 20, 2023

The spectrum of major and minor salivary gland disorders varies widely. Epidemiological data on some injury categories are rare often not up-to-date. This study aims to analyze epidemiological using clinical, paraclinical, histopathological parameters. Study was carried out for 5 years the nonneoplastic tumoral pathology glands. Data were statistically analyzed appropriate analysis according biological behavior lesions revealed great heterogeneity. Statistically significant correlations observed between type injury, age (P = .002) gender (0.033). environment origin patients as well comorbidities reflected in most cases nature process. Associations also hemicranial topography .019), .024), surgical technique used < .001). Most identified glands, parotid. common diseases represented by nonspecific chronic sialadenitis (nonneoplastic lesion), pleomorphic adenoma Warthin tumor (benign tumors), mucoepidermoid carcinoma (malignant tumor), squamous (secondary tumor). They presented axial diameters 2 95 mm. curative subtotal excision with facial nerve preservation. In conclusion, highlighted main aspects disorders. Some agree specialty literature, particular observed. Therefore, this research is useful both medical fields.

Language: Английский

Citations

2