Photodynamic and Sonodynamic Therapy Synergy: Mechanistic Insights and Cellular Responses Against Glioblastoma Multiforme DOI
Swati Sharma,

Geetanjali B. Gone,

Parikshit Roychowdhury

et al.

Journal of drug targeting, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 23

Published: Nov. 18, 2024

Glioblastoma multiforme (GBM), the most aggressive form of brain cancer, poses substantial challenges to effective treatment due its complex and infiltrative nature, making it difficult manage. Photodynamic therapy (PDT) sonodynamic (SDT), have emerged as promising individual options against GBM their least-invasive approach. However, both PDT SDT drawbacks that require careful consideration. A combination using light sound waves has gained attention, offering new avenues overcome from therapies. Sono-photodynamic (SPDT) been used various tumors. Researchers are considering SPDT a favorable alternative conventional therapies for GBM. offers complementary mechanisms action, including production ROS, disruption cellular structures, induction apoptosis, leading enhanced tumor cell death. This review gives an insight about PDT/SDT limitations in need therapy. We try unveil process explore mechanism behind improved SPDT-meditated death cells by focusing on ROS-mediated response occurring result discussing current modifications existing sensitizers optimal use

Language: Английский

Glioblastoma Therapy: Past, Present and Future DOI Open Access
Elena Obrador, Paz Moreno-Murciano, María Oriol‐Caballo

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(5), P. 2529 - 2529

Published: Feb. 21, 2024

Glioblastoma (GB) stands out as the most prevalent and lethal form of brain cancer. Although great efforts have been made by clinicians researchers, no significant improvement in survival has achieved since Stupp protocol became standard care (SOC) 2005. Despite multimodality treatments, recurrence is almost universal with rates under 2 years after diagnosis. Here, we discuss recent progress our understanding GB pathophysiology, particular, importance glioma stem cells (GSCs), tumor microenvironment conditions, epigenetic mechanisms involved growth, aggressiveness recurrence. The discussion on therapeutic strategies first covers SOC treatment targeted therapies that shown to interfere different signaling pathways (pRB/CDK4/RB1/P16

Language: Английский

Citations

61
Lipid Nanocarriers as Precision Delivery Systems for Brain Tumors DOI
Roshan Keshari,

Mahima Dewani,

Navneet Kaur

et al.

Bioconjugate Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 12, 2025

Brain tumors, particularly glioblastomas, represent the most complicated cancers to treat and manage due their highly invasive nature protective barriers of brain, including blood-brain barrier (BBB). The efficacy currently available treatments, viz., radiotherapy, chemotherapy, immunotherapy, are frequently limited by major side effects, drug resistance, restricted penetration into brain. Lipid nanoparticles (LNPs) have emerged as a promising targeted delivery system for brain tumors. nanocarriers gained tremendous attention tumor therapeutics multiple encapsulation abilities, controlled release, better biocompatibility, ability cross BBB. Herein, detailed analysis design, mechanisms, therapeutic benefits LNPs in treatment is discussed. Moreover, we also discuss safety issues clinical developments current future challenges. Further, focused on transformation therapy eliminating effects engineering overcome related biological barriers, which provide personalized, affordable, low-risk options.

Language: Английский

Citations

2
Platinum-based drugs in cancer treatment: Expanding horizons and overcoming resistance DOI
Mona Shahlaei,

Shaahin Mohammadzadeh Asl,

Atefe Derakhshani

et al.

Journal of Molecular Structure, Journal Year: 2023, Volume and Issue: 1301, P. 137366 - 137366

Published: Dec. 19, 2023

Language: Английский

Citations

23
Revolutionizing Glioblastoma Treatment: A Comprehensive Overview of Modern Therapeutic Approaches DOI Open Access
Karol Sadowski, Adrianna Jażdżewska,

Jan Kozłowski

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 5774 - 5774

Published: May 26, 2024

Glioblastoma is the most common malignant primary brain tumor in adult population, with an average survival of 12.1 to 14.6 months. The standard treatment, combining surgery, radiotherapy, and chemotherapy, not as efficient we would like. However, current possibilities are no longer limited therapies due rapid advancements biotechnology. New methods enable a more precise approach by targeting individual cells antigens overcome cancer. For treatment glioblastoma, these gamma knife therapy, proton beam tumor-treating fields, EGFR VEGF inhibitors, multiple RTKs PI3K pathway inhibitors. In addition, increasing understanding role immune system tumorigenesis ability identify tumor-specific helped develop immunotherapies GBM cells, including CAR-T, CAR-NK dendritic checkpoint Each described has its advantages disadvantages faces problems, such inefficient crossing blood-brain barrier, various neurological systemic side effects, escape mechanism tumor. This work aims present modern treatments glioblastoma.

Language: Английский

Citations

14
Cannabidiol induces ERK activation and ROS production to promote autophagy and ferroptosis in glioblastoma cells DOI
Na Young Kim,

Siddegowda Gopalapura Shivanne Gowda,

Seok‐Geun Lee

et al.

Chemico-Biological Interactions, Journal Year: 2024, Volume and Issue: 394, P. 110995 - 110995

Published: April 5, 2024

Language: Английский

Citations

13
Integrating Rapid Evaporative Ionization Mass Spectrometry Classification with Matrix-Assisted Laser Desorption Ionization Mass Spectrometry Imaging and Liquid Chromatography-Tandem Mass Spectrometry to Unveil Glioblastoma Overall Survival Prediction DOI Creative Commons
Tim Hendriks,

Angeliki Birmpili,

Steven De Vleeschouwer

et al.

ACS Chemical Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

Glioblastoma multiforme (GBM) is a highly aggressive brain cancer with median survival of 15 months. Despite advancements in conventional treatment approaches such as surgery and chemotherapy, the prognosis remains poor. This study investigates use rapid evaporative ionization mass spectrometry (REIMS) for real-time overall time classification GBM samples uses matrix-assisted laser desorption imaging (MALDI-MSI) to compare lipidomic differences within tumors. A total 45 biopsies were analyzed develop prediction model IDH-wild type GBM. REIMS patterns from 28 patients classified 97.7% correct rate, identifying key discriminators between short-term (0–12 months) prolonged (>12 survivors. Cross-validation additional showed that correctly 66.7 69.4% accuracy, respectively. MALDI-MSI was performed confirm derived data. Results indicated 42 33 discriminating features survival, Proteomic profiling by isolating tumor regions via laser-capture microdissection (LMD) liquid chromatography-tandem (LC-MS/MS). Subsequently, 1387 proteins identified, which 79 significantly altered. In conclusion, this shows rapidly predicts glioblastoma times based on profiles during electrosurgical dissection. confirmed these specific region sections. LMD-guided LC-MS/MS-based proteomics revealed altered pathways survival. research, including comprehensive predictive GBM, could guide resection surgeries accurate tissue identification well provide insights into mechanisms, possibly related therapy response.

Language: Английский

Citations

1
Advancements in the Application of Nanomedicine in Alzheimer’s Disease: A Therapeutic Perspective DOI Open Access
Nidhi Puranik, Dhananjay Yadav, Minseok Song

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(18), P. 14044 - 14044

Published: Sept. 13, 2023

Alzheimer’s disease (AD) is a progressive neurodegenerative that affects most people worldwide. AD complex central nervous system disorder. Several drugs have been designed to cure AD, but with low success rates. Because the blood–brain and blood–cerebrospinal fluid barriers are two protect system, their presence has severely restricted efficacy of many treatments studied for diagnosis and/or therapy. The use nanoparticles treatment focus an established rapidly developing field nanomedicine. Recent developments in nanomedicine made it possible effectively transport brain. However, numerous obstacles remain successful nanomedicines clinical settings treatment. Furthermore, given rapid advancement therapeutics, better outcomes patients can be anticipated. This article provides overview recent using different types management AD.

Language: Английский

Citations

19
Insights into the roles of non-coding RNAs and angiogenesis in glioblastoma: An overview of current research and future perspectives DOI

Zhengfei Song,

Zhaoliang Xue,

Yirong Wang

et al.

Biochimica et Biophysica Acta (BBA) - General Subjects, Journal Year: 2024, Volume and Issue: 1868(4), P. 130567 - 130567

Published: Jan. 21, 2024

Language: Английский

Citations

7
HER2-targeting CAR-T cells show highly efficient anti-tumor activity against glioblastoma both in vitro and in vivo DOI Creative Commons
Xueying Li, Lifen Zhao, Wenzhe Li

et al.

Genes and Immunity, Journal Year: 2024, Volume and Issue: 25(3), P. 201 - 208

Published: May 3, 2024

Glioblastoma (GBM) is the most common and aggressive malignant primary brain tumor in adults. Current treatment options for GBM include surgical resection, radiation, chemotherapy, which predominantly slow cancer growth reduce symptoms, resulting a 5-year survival rate of no more than 10%. Chimeric antigen receptor (CAR) T-cell therapy new class cellular immunotherapy that has made great progress treating tumors. Human epidermal factor 2 (HER2) overexpressed may provide potential therapeutic target treatment. In this study, we constructed third-generation CAR-T cells targeting HER2 GBM. HER2-CAR-T showed effective anti-tumor activity both vitro vivo. Furthermore, HER2-specific exhibited strong cytotoxicity cytokine-secreting abilities against vitro. Anti-HER2 also increased with increasing effector-to-target ratios. delivered via peritumoral injection successfully stunted progression Moreover, intravenous administration anti-HER2 resulted improvement compared administration. conclusion, our study shows represent an emerging

Language: Английский

Citations

7
The Lipidomic Signature of Glioblastoma: A Promising Frontier in Cancer Research DOI Open Access
Nina Yu, Orwa Aboud

Cancers, Journal Year: 2024, Volume and Issue: 16(6), P. 1089 - 1089

Published: March 8, 2024

Glioblastoma is the most aggressive primary brain malignancy in adults, and has a survival duration of approximately 15 months. First line treatment involves surgical resection, chemotherapy, radiation, but despite multi-pronged approach advances cancer research, glioblastoma remains devastating with high mortality rate. Lipidomics an emerging discipline that studies lipid pathways characteristics, promising field to understand biochemical mechanisms. In glioblastoma, disrupted homeostasis been reported literature. A thorough understanding serum lipidomics may offer ways better biomarkers, prognosis, options. Here, we review literature, offering future directions for research glioblastomas.

Language: Английский

Citations

6