International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(24), P. 13657 - 13657
Published: Dec. 20, 2024
Osteosarcoma
(OS)
is
the
most
prevalent
malignant
bone
tumor
in
adolescents
and
young
adults.
OS
cells
grow
a
permissive
local
microenvironment
which
modulates
their
behavior
facilitates
all
steps
development
(e.g.,
proliferation/quiescence,
invasion/migration,
drug
resistance)
contributes
to
intrinsic
heterogeneity.
The
lung
parenchyma
common
metastatic
site
OS,
foci
are
frequently
associated
with
poor
clinical
outcome.
Although
multiple
factors
may
be
responsible
for
disease,
including
genetic
mutations
Rb
p53),
molecular
mechanism
of
remains
unclear,
conventional
treatment
still
based
on
sequential
approach
that
combines
chemotherapy
surgery.
Also,
despite
increase
trials,
survival
rates
have
not
improved.
Non-specific
targeting
therapies
thus
show
therapeutic
effects,
along
side
effects
at
high
doses.
For
these
reasons,
many
efforts
been
made
characterize
complex
genome
thanks
whole-exome
analysis,
aim
identifying
predictive
biomarkers
give
patients
better
option.
This
review
aims
summarize
discuss
main
recent
advances
research
precision
medicine.
International Journal of Computational and Experimental Science and Engineering,
Journal Year:
2025,
Volume and Issue:
11(1)
Published: Feb. 12, 2025
Bone
cancer,
especially
osteosarcoma,
is
an
aggressive
tumor
with
a
highly
complex
histopathologic
appearance
that
imposes
considerable
diagnostic
difficulties.
Although
practical
and
efficient,
traditional
methods
current
deep
learning
models
have
class
imbalance,
fused
pixel
intensity
distributions,
tissue
heterogeneity
hinder
efficiency.
These
problems
emphasize
the
demand
of
more
sophisticated
frameworks
specifically
address
distinct
properties
bone
cancer
histopathology
images.
To
overcome
these
shortcomings,
in
this
study
proposes
framework,
IBCDNet,
to
alleviate
limitations.
Inspired
by
cutting-edge
improvements
architecture
(e.g.,
like
attention,
residual
connections,
proposed
Intelligent
Learning-Based
Cancer
Detection
(ILB-BCD)
algorithm),
framework
combines
different
features
from
both
public
private
datasets
efficient
way.
This
allows
for
strong
feature
extraction,
better
imbalanced
data,
thus
precise
classification.
The
model
obtains
state-of-the-art
results
98.39%
on
Osteosarcoma
Tumor
Assessment
Dataset,
outperforming
powerful
baseline
ResNet50,
DenseNet121,
InceptionV3.
further
affirms
its
robustness
respective
precision
(97.8%),
recall
(98.1%),
F1-score
(98.0%)
which
shows
remarkable
improvement
We
present
cost-effective
scalable
real-world
clinical
applications
assist
pathologists
early
detection
accurate
diagnosis
cancer.
Those
important
gaps
identified
addressed
research
contribute
progress
towards
AI-driven
healthcare
global
goals
medicine
enhanced
patient
outcomes.
Applied Data Science and Analysis,
Journal Year:
2024,
Volume and Issue:
2024, P. 52 - 68
Published: May 29, 2024
Background:
Osteosarcoma
is
considered
as
the
primary
malignant
tumor
of
bone,
emanating
from
primitive
mesenchymal
cells
that
form
osteoid
or
immature
bone.
Accurate
diagnosis
and
classification
play
a
key
role
in
management
planning
to
achieve
improved
patient
outcomes.
Machine
learning
techniques
may
be
used
augment
surpass
existing
conventional
methods
towards
an
analysis
medical
data.
Methods:
In
present
study,
combination
feature
selection
was
development
predictive
models
osteosarcoma
cases.
The
include
L1
Regularization
(Lasso),
Recursive
Feature
Elimination
(RFE),
SelectKBest,
Tree-based
Importance,
while
following
were
applied:
Voting
Classifier,
Decision
Tree,
Naive
Bayes,
Multi-Layer
Perceptron,
Random
Forest,
Logistic
Regression,
AdaBoost,
Gradient
Boosting.
Some
model
assessment
done
by
combining
metrics
such
accuracy,
precision,
recall,
F1
score,
AUC,
V
score.
Results:
Tree-Based
Importance
for
Classifier
with
Tree
proved
giving
higher
performance
compared
all
other
combinations,
where
combinations
helped
correct
positive
instances
wonderful
minimization
false
positives.
Other
also
gave
significant
performances
but
slightly
less
effective,
example,
RFE
Classifier.
Conclusion:
This
work
presents
strong
evidence
advanced
machine
ensemble
classifiers
robust
can
result
overall
improvement
diagnostic
accuracy
robustness
osteosarcoma.
Research
on
class
imbalance
computational
efficiency
will
its
future
research
priority.
This
work
introduces
EffiSegNet,
a
novel
segmentation
framework
leveraging
transfer
learning
with
pre-trained
Convolutional
Neural
Network
(CNN)
classifier
as
its
backbone.
Deviating
from
traditional
architectures
symmetric
U-shape,
EffiSegNet
simplifies
the
decoder
and
utilizes
full-scale
feature
fusion
to
minimize
computational
cost
number
of
parameters.
We
evaluated
our
model
on
gastrointestinal
polyp
task
using
publicly
available
Kvasir-SEG
dataset,
achieving
state-of-the-art
results.
Specifically,
EffiSegNet-B4
network
variant
achieved
an
F
1
score
0.9552,
mean
Dice
(mDice)
0.9483,
Intersection
over
Union
(mIoU)
0.9056,
Precision
0.9679,
Recall
0.9429
backbone
-
best
knowledge,
highest
reported
scores
in
literature
for
this
dataset.
Additional
training
scratch
also
demonstrated
exceptional
performance
compared
previous
work,
0.9286,
mDice
0.9207,
mIoU
0.8668,
0.9311
0.9262.
These
results
underscore
importance
well-designed
encoder
image
networks
effectiveness
approaches.
Diagnostics,
Journal Year:
2023,
Volume and Issue:
13(12), P. 2106 - 2106
Published: June 18, 2023
Osteosarcoma
is
the
most
common
type
of
bone
cancer
that
tends
to
occur
in
teenagers
and
young
adults.
Due
crowded
context,
inter-class
similarity,
variation,
noise
H&E-stained
(hematoxylin
eosin
stain)
histology
tissue,
pathologists
frequently
face
difficulty
osteosarcoma
tumor
classification.
In
this
paper,
we
introduced
a
hybrid
framework
for
improving
efficiency
three
types
(nontumor,
necrosis,
viable
tumor)
classification
by
merging
different
CNN-based
architectures
with
multilayer
perceptron
(MLP)
algorithm
on
WSI
(whole
slide
images)
dataset.
We
performed
various
kinds
preprocessing
images.
Then,
five
pre-trained
CNN
models
were
trained
multiple
parameter
settings
extract
insightful
features
via
transfer
learning,
where
convolution
combined
pooling
was
utilized
as
feature
extractor.
For
selection,
decision
tree-based
RFE
designed
recursively
eliminate
less
significant
improve
model
generalization
performance
accurate
prediction.
Here,
tree
used
an
estimator
select
features.
Finally,
modified
MLP
classifier
employed
classify
binary
multiclass
under
five-fold
CV
assess
robustness
our
proposed
model.
Moreover,
selection
criteria
analyzed
optimal
one
based
their
execution
time
accuracy.
The
achieved
accuracy
95.2%
99.4%
Experimental
findings
indicate
significantly
outperforms
existing
methods;
therefore,
could
be
applicable
support
doctors
diagnosis
clinics.
addition,
integrated
into
web
application
using
FastAPI
provide
real-time
Bioengineering,
Journal Year:
2025,
Volume and Issue:
12(4), P. 413 - 413
Published: April 13, 2025
Background:
Ulcerative
colitis
(UC)
is
a
chronic
inflammatory
bowel
disease
characterized
by
continuous
inflammation
of
the
colon
and
rectum.
Accurate
assessment
essential
for
effective
treatment,
with
endoscopic
evaluation,
particularly
Mayo
Endoscopic
Score
(MES),
serving
as
key
diagnostic
tool.
However,
MES
measurement
can
be
subjective
inconsistent,
leading
to
variability
in
treatment
decisions.
Deep
learning
approaches
have
shown
promise
providing
more
objective
standardized
assessments
UC
severity.
Methods:
This
study
utilized
publicly
available
images
patients
analyze
compare
performance
state-of-the-art
deep
neural
networks
automated
classification.
Several
architectures
were
tested
determine
most
model
grading
The
F1
score,
accuracy,
recall,
precision
calculated
all
models,
statistical
analysis
was
conducted
verify
statistically
significant
differences
between
networks.
Results:
VGG19
found
best-performing
network,
achieving
QWK
score
0.876
macro-averaged
0.7528
across
classes.
among
top-performing
models
very
small
suggesting
that
selection
should
depend
on
specific
deployment
requirements.
Conclusions:
demonstrates
multiple
network
could
automate
severity
Simpler
achieve
competitive
results
larger
challenging
assumption
necessarily
provide
better
clinical
outcomes.
Frontiers in Medicine,
Journal Year:
2025,
Volume and Issue:
12
Published: April 16, 2025
Recent
advances
in
machine
learning
are
transforming
medical
image
analysis,
particularly
cancer
detection
and
classification.
Techniques
such
as
deep
learning,
especially
convolutional
neural
networks
(CNNs)
vision
transformers
(ViTs),
now
enabling
the
precise
analysis
of
complex
histopathological
images,
automating
detection,
enhancing
classification
accuracy
across
various
types.
This
study
focuses
on
osteosarcoma
(OS),
most
common
bone
children
adolescents,
which
affects
long
bones
arms
legs.
Early
accurate
OS
is
essential
for
improving
patient
outcomes
reducing
mortality.
However,
increasing
prevalence
demand
personalized
treatments
create
challenges
achieving
diagnoses
customized
therapies.
We
propose
a
novel
hybrid
model
that
combines
(CNN)
(ViT)
to
improve
diagnostic
using
hematoxylin
eosin
(H&E)
stained
images.
The
CNN
extracts
local
features,
while
ViT
captures
global
patterns
from
These
features
combined
classified
Multi-Layer
Perceptron
(MLP)
into
four
categories:
non-tumor
(NT),
non-viable
tumor
(NVT),
viable
(VT),
ratio
(NVR).
Using
Cancer
Imaging
Archive
(TCIA)
dataset,
achieved
an
99.08%,
precision
99.10%,
recall
99.28%,
F1-score
99.23%.
first
successful
four-class
this
setting
new
benchmark
research
offering
promising
potential
future
advancements.