Whole-Exome Analysis and Osteosarcoma: A Game Still Open DOI Open Access
Caterina Chiappetta, Carlo Della Rocca, Claudio Di Cristofano

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(24), P. 13657 - 13657

Published: Dec. 20, 2024

Osteosarcoma (OS) is the most prevalent malignant bone tumor in adolescents and young adults. OS cells grow a permissive local microenvironment which modulates their behavior facilitates all steps development (e.g., proliferation/quiescence, invasion/migration, drug resistance) contributes to intrinsic heterogeneity. The lung parenchyma common metastatic site OS, foci are frequently associated with poor clinical outcome. Although multiple factors may be responsible for disease, including genetic mutations Rb p53), molecular mechanism of remains unclear, conventional treatment still based on sequential approach that combines chemotherapy surgery. Also, despite increase trials, survival rates have not improved. Non-specific targeting therapies thus show therapeutic effects, along side effects at high doses. For these reasons, many efforts been made characterize complex genome thanks whole-exome analysis, aim identifying predictive biomarkers give patients better option. This review aims summarize discuss main recent advances research precision medicine.

Language: Английский

Osteosarcoma cancer detection using ghost-faster RCNN model from histopathological images DOI

S. Stephe,

B. N. Manjunatha,

V. Revathi

et al.

Iran Journal of Computer Science, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

Language: Английский

Citations

0
Detection of Osteosarcoma Bone Cancer Using Supervised Deep Learning and Convolutional Neural Networks DOI

Nithya Sree,

E. Laxmi Lydia,

P. Aruna Kumari

et al.

Lecture notes in networks and systems, Journal Year: 2024, Volume and Issue: unknown, P. 337 - 346

Published: Jan. 1, 2024

Language: Английский

Citations

0
Whole-Exome Analysis and Osteosarcoma: A Game Still Open DOI Open Access
Caterina Chiappetta, Carlo Della Rocca, Claudio Di Cristofano

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(24), P. 13657 - 13657

Published: Dec. 20, 2024

Osteosarcoma (OS) is the most prevalent malignant bone tumor in adolescents and young adults. OS cells grow a permissive local microenvironment which modulates their behavior facilitates all steps development (e.g., proliferation/quiescence, invasion/migration, drug resistance) contributes to intrinsic heterogeneity. The lung parenchyma common metastatic site OS, foci are frequently associated with poor clinical outcome. Although multiple factors may be responsible for disease, including genetic mutations Rb p53), molecular mechanism of remains unclear, conventional treatment still based on sequential approach that combines chemotherapy surgery. Also, despite increase trials, survival rates have not improved. Non-specific targeting therapies thus show therapeutic effects, along side effects at high doses. For these reasons, many efforts been made characterize complex genome thanks whole-exome analysis, aim identifying predictive biomarkers give patients better option. This review aims summarize discuss main recent advances research precision medicine.

Language: Английский

Citations

0