Role of Hyperbaric Oxygen Therapy in Prostate Tumor Microenvironment and Cancer Stem Cell Niche

annals of urologic oncology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 15, 2024

Hyperbaric oxygen therapy (HBOT), has gained attention in recent years as a potential adjunct to conventional cancer treatments, particularly addressing tumor hypoxia which is extensively employed post-injury treatment, the administration of >92% at 1.5- 3.0 ATA for 60-120 minutes. HBOT attributed least five mechanisms including epigenetic regulation gene expression, mechanical effects, bacteriostatic hyperoxygenation carbon monoxide and cyanide poisoning restoration from hypoxia. emerging promising overcoming hypoxia—a key feature microenvironment (TME) that drives growth, resistance, metastasis. By delivering high concentrations under pressure, improves tissue oxygenation, potentially suppressing reducing hypoxia-induced enhancing efficacy chemotherapy radiotherapy. Studies have shown its anti-angiogenic effects some models ability alkalize TME. In prostate cancer, demonstrated slowing growth increasing treatment sensitivity cell lines like DU-145 LNCaP. Additionally, it may enhance effectiveness radical prostatectomy by synchronizing cycles. Therefore, current review highlights aspects their role late radiation injury (LRTI) We succinctly captured multifaceted modifying TME comprehensive overview focuses on advanced approaches eliminate stem cells (PCSCs) exploration anti-androgen well stemness-related signaling pathways growing body evidence supporting benefits treatment. Further clinical research could lead significant advancements

Language: Английский

Understanding the Role of Cancer Stem Cells in Brain Tumor Pathogenesis

Stem cell biology and regenerative medicine, Journal Year: 2024, Volume and Issue: unknown, P. 227 - 255

Published: Jan. 1, 2024

Language: Английский