From Electrons to Cancer: Redox Shift as a Driving Force of Tumorigenesis DOI
Romain Attal, Ashraf Bakkar, Frédéric Bouillaud

et al.

Published: Jan. 1, 2023

Cancer cells are very diverse but mostly share a common metabolic property: they strongly glycolytic even though oxygen is available. Herein, the abnormalities of cancer interpreted as modifications electric currents in redox reactions. A lower current electron transport chain, an increase concentration reduced cofactors and partial reversal tricarboxylic acid cycle physical characteristics several forms cancer. The existence short-circuits between oxidative branches reductive network argue favor electronic approach nanoscopic scale. These changes flows induce pseudo-hypoxia Warburg effect through succinate production divert electrons from to biosynthetic pathways. This new look at may have potential therapeutic applications.

Language: Английский

From Electrons to Cancer: Redox Shift as a Driving Force of Tumorigenesis DOI
Romain Attal, Ashraf Bakkar, Frédéric Bouillaud

et al.

Published: Jan. 1, 2023

Cancer cells are very diverse but mostly share a common metabolic property: they strongly glycolytic even though oxygen is available. Herein, the abnormalities of cancer interpreted as modifications electric currents in redox reactions. A lower current electron transport chain, an increase concentration reduced cofactors and partial reversal tricarboxylic acid cycle physical characteristics several forms cancer. The existence short-circuits between oxidative branches reductive network argue favor electronic approach nanoscopic scale. These changes flows induce pseudo-hypoxia Warburg effect through succinate production divert electrons from to biosynthetic pathways. This new look at may have potential therapeutic applications.

Language: Английский

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