The role of magnetic resonance imaging in cervical embryonal rhabdomyosarcoma: the first reported case in an Indonesian adolescent

The Egyptian Journal of Radiology and Nuclear Medicine, Journal Year: 2025, Volume and Issue: 56(1)

Published: March 18, 2025

Abstract Background The uterine cervix is a rare location for embryonal rhabdomyosarcoma (ERMS), accounting only 0.2% of malignant tumours in adult females. This case report presents 16-year-old female with heavy extra-menstrual bleeding, more deliberate focus towards the radiological challenge interpreting cervical ERMS. Case Report A presented intermittent lower abdominal pain, nausea, vomiting, difficulty defecating, and severe vaginal bleeding. She had history high-grade sarcoma diagnosed four months prior, histopathology inconclusive between leiomyosarcoma. Physical examination revealed anaemia polypoid mass protruding from cervix. received blood transfusions to address anaemia. Persistent symptoms led another transfusion chemotherapy regimen (vincristine, actinomycin D, ifosfamide, paclitaxel, carboplatin). Follow-up imaging initially showed no masses, but subsequent MRI heterogeneous extending uterus proximal vagina. total hysterectomy was performed, confirmed Post-operative residual tumour, patient continued follow-up sessions. Conclusion highlights complexities diagnosing managing ERMS adolescents. crucial evaluating tumour extent guiding treatment.

Language: Английский

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Atypical Pelvic Tumors in Children

Cancers, Journal Year: 2025, Volume and Issue: 17(4), P. 619 - 619

Published: Feb. 12, 2025

Due to the complex anatomy of pelvis, various tumors may arise in this region. Some these are well known and have distinctive features that allow them be identified by magnetic resonance imaging (MRI). These include sacrococcygeal teratoma (SCT), most prevalent congenital tumor children, often diagnosed prenatally frequently occurring anatomical location, ovarian teratoma, which its mature form is common neoplasm children adolescents. Additionally, rhabdomyosarcoma (RMS), commonly found bladder both genders prostate males, Ewing sarcoma (ES), affecting flat bones relatively tumors. In study, selected atypical pelvic presented. Most reproductive system, such as cervical cancer, small cell neuroendocrine carcinoma ovary, ES/primitive neuroectodermal (PNET) diffuse large B-cell lymphoma (DLBCL) ovaries Sertoli–Leydig (SLCT) with RMS due DICER1 syndrome. originating from nervous including neuroblastoma (NBL) plexiform neurofibroma (pNF), associated not neurofibromatosis type 1 (NF1), discussed. Furthermore, Rosai–Dorfman disease involving inguinal lymph nodes By reviewing literature presenting our cases, we tried find radiological individual would bring radiologist closer correct diagnosis, ensuring implementation appropriate treatment. However, MR images cannot considered isolation. Additional patient data, clinical picture, comorbidities/syndromes, laboratory test results, necessary.

Language: Английский

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Pediatric Urologic Oncology Series – Bladder/Prostate Rhabdomyosarcoma

Urology, Journal Year: 2024, Volume and Issue: 193, P. 2 - 7

Published: Aug. 27, 2024

Language: Английский

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How Many Lymph Nodes are Enough in Paratesticular Rhabdomyosarcoma?

Journal of Pediatric Surgery, Journal Year: 2024, Volume and Issue: 60(2), P. 162040 - 162040

Published: Oct. 30, 2024

Language: Английский

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Rhabdomyosarcoma of the Prostate in Adolescent Presenting With Urinary Retention

Clinical Pediatrics, Journal Year: 2024, Volume and Issue: 63(12), P. 1641 - 1644

Published: March 7, 2024

Language: Английский

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Prostatic rhabdomyosarcoma in a 6 years old patient evaluated by [18F]FDG PET/CT

Revista Española de Medicina Nuclear e Imagen Molecular (English Edition), Journal Year: 2024, Volume and Issue: unknown, P. 500016 - 500016

Published: May 1, 2024

Language: Английский

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Rabdomiosarcoma prostático en un paciente de seis años evaluado mediante [18F]FDG PET/TC

Revista Española de Medicina Nuclear e Imagen Molecular, Journal Year: 2024, Volume and Issue: unknown

Published: June 1, 2024

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Acute Stroke with Hyperdense MCA Sign in an Adolescent Female with Tyrosine Kinase Inhibitor Treatment- What You Need to Know

Journal of Emergency Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Language: Английский

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Analysis of Genitourinary Rhabdomyosarcoma in Phase 3 Clinical Trials

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 16, 2024

Purpose: Pediatric Rhabdomyosarcoma (RMS) is a morbid and often lethal condition characterized by paucity of clinical data. Beyond detailed risk categorization system, it unclear if genitourinary (GU) sites (bladder/prostate, paratesticular, female organs) have outcomes distinct from non-GU sites. This study pools primary data phase-3 trials involving pediatric RMS to evaluate this question. Methods Materials: We obtained three Children’s Oncology Group (NCT00075582, NCT00354744, NCT00354835) evaluating low- (LR), intermediate- (IMR), high (HR) RMS. Survival analysis was conducted using the Kaplan-Meier method, with Event-Free (EFS) defined per protocol specifications. Results: 599 subject records were included in (111 GU RMS, 488 RMS). For subjects overall survival (OS) superior (HRR 0.55, 95% CI 0.35-0.87, p=0.009). In same group EFS superiority not statistically significant compared 0.88 CI, 0.63-1.22, p=0.43). LR population, site associated improved OS that 0.37 0.07-1.84, p=0.21) less favorable 2.84 1.13-7.12, p=0.02). Conclusions: linked sites, although shows EFS. Our findings reinforce association between better warranting further investigation into surrogacy for

Language: Английский

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Pediatric Genitourinary Tumors

Surgical pathology clinics, Journal Year: 2024, Volume and Issue: 18(1), P. 191 - 207

Published: Nov. 16, 2024

Language: Английский

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