The Journal of Gene Medicine,
Journal Year:
2023,
Volume and Issue:
26(1)
Published: Nov. 23, 2023
Abstract
Background
In
breast
cancer
(BC),
homologous
recombination
defect
(HRD)
is
a
common
carcinogenic
mechanism.
It
meaningful
to
classify
BC
according
HRD
biomarkers
and
develop
platform
for
identifying
molecular
features,
pathological
features
therapeutic
responses.
Methods
total,
109
genes
were
collected
screened
by
univariate
Cox
regression
analysis
determine
the
prognostic
genes,
which
used
construct
consensus
matrix
identify
subtype.
Differentially
expressed
(DEGs)
filtered
Limma
package
random
forest
build
model
analyze
immunotherapy
response
sensitivity
prognosis
of
patients
suffering
from
different
drugs.
Results
Thirteen
out
BC,
was
classified
into
two
subgroups
based
on
their
expression.
Cluster
1
had
significantly
backward
survival
outcome
higher
adaptive
immunity
score
relative
cluster
2.
Six
identified
as
factors
developing
model.
The
provided
prediction
called
risk
score,
showed
significant
stratification
effect
prognosis,
IC
50
values
62
Conclusions
present
study,
subtypes
successfully
identified,
mutation
immunological
determined.
A
differential
established,
potential
predictor
drug
BC.
Cancers,
Journal Year:
2023,
Volume and Issue:
15(15), P. 3826 - 3826
Published: July 27, 2023
Colorectal
cancer
(CRC)
poses
a
significant
challenge
in
healthcare,
necessitating
the
exploration
of
novel
therapeutic
strategies.
Natural
compounds
such
as
polyphenols
with
inherent
anticancer
properties
have
gained
attention
potential
agents.
This
review
highlights
need
for
approaches
CRC,
followed
by
discussion
on
synthesis
polyphenols-based
nanoparticles.
Various
techniques,
including
dynamic
covalent
bonding,
non-covalent
polymerization,
chemical
conjugation,
reduction,
and
metal-polyphenol
networks,
are
explored.
The
mechanisms
action
these
nanoparticles,
encompassing
passive
active
targeting
mechanisms,
also
discussed.
further
examines
intrinsic
activity
their
enhancement
through
nano-based
delivery
systems.
section
explores
natural
investigates
different
systems,
micelles,
nanogels,
liposomes,
nanoemulsions,
gold
mesoporous
silica
metal–organic
frameworks.
concludes
emphasizing
nanoparticle-based
strategies
utilizing
CRC
treatment
future
research
to
optimize
efficacy
safety.
Overall,
this
provides
valuable
insights
into
synthesis,
action,
activity,
nanoparticles
treatment.
Cancer Cell International,
Journal Year:
2024,
Volume and Issue:
24(1)
Published: Feb. 6, 2024
Abstract
Peroxiredoxin
3
(PRDX3),
a
mitochondrial
hydrogen
peroxide
scavenger,
is
known
to
be
upregulated
during
tumorigenesis
and
cancer
progression.
In
this
study,
we
provide
evidence
for
the
first
time
that
PRDX3
could
regulate
cellular
signaling
pathways
associated
with
Matrix
Metalloproteinase-1
(MMP-1)
expression
activity
in
breast
We
show
shRNA-mediated
gene
silencing
of
inhibits
cell
migration
invasion
two
triple-negative
lines.
Reciprocal
experiments
overexpression
promotes
cells,
processes
which
are
important
metastatic
cascade.
Notably,
phenomenon
may
attributed
activation
MMP-1,
observed
by
cells.
Moreover,
immunohistochemical
staining
tissues
revealed
positive
correlation
between
MMP-1
both
epithelial
stromal
parts
tissues.
Further
pathway
reporter
array
luciferase
assay
demonstrated
ERK
responsible
transcriptional
PRDX3-overexpressed
These
findings
suggest
mediate
spread
via
ERK-mediated
MMP-1.
Targeted
inhibition
able
inhibit
tumor
metastasis
cancer.
Applied Sciences,
Journal Year:
2024,
Volume and Issue:
14(5), P. 1809 - 1809
Published: Feb. 22, 2024
Breast
cancer
(BC)
ranks
among
the
most
diagnosed
solid
tumors
worldwide.
For
decades,
significant
research
efforts
have
been
dedicated
to
finding
selective
treatments
for
these
tumors.
Currently,
primary
treatment
method
BC
involves
surgery,
with
subsequent
utilization
of
radiotherapy
and
chemotherapy.
However,
often
fall
short
effectively
treating
due
their
side
effects
harm
healthy
tissues.
Today,
a
range
nanoparticles
are
being
developed
target
cells
without
affecting
surrounding
This
in-depth
review,
based
on
studies,
seeks
shed
light
specially
designed
potential
in
treatment.
Typically,
therapeutic
drugs
or
naturally
occurring
bioactive
compounds
incorporated
into
precisely
crafted
nanoparticles.
enhances
solubility,
longevity
bloodstream,
distribution
body
while
also
minimizing
immune
reactions.
Nanoparticles
address
shortcomings
standalone
therapeutics
traverse
various
biological
obstacles
spanning
systemic,
microenvironmental,
cellular
that
differ
patients
diseases.
We
prioritize
breakthroughs
nanoparticle
design
surpass
diverse
delivery
believe
smart
engineering
not
only
effectiveness
general
but
allows
customized
solutions
specific
needs,
ultimately
leading
better
outcomes
patients.
Discover Oncology,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: March 6, 2025
Nanomedicine
offers
fresh
approaches
for
breast
cancer
treatment,
countering
traditional
limitations.
The
nanodrug
delivery
system's
precision
and
biocompatibility
hold
promise,
yet
integration
hurdles
remain.
This
study
reviews
nano
systems
in
therapy
from
2013
to
2023,
guiding
future
research
directions.
In
this
study,
we
conducted
a
comprehensive
search
on
Web
of
Science
database
(Guilin
Medical
University
purchase
edition)
downloaded
literature
related
the
field
published
between
2023.
We
analyzed
these
publications
using
R
software,
VOSviewer,
CiteSpace
software.
reviewed
2632
documents,
showing
steady
publication
increase
peaking
at
408
2022.
China,
USA,
India,
Iran
were
prominent
publishing.
Chinese
Academy
Sciences
Tabriz
key
collaboration
centers.
Notably,
Journal
Controlled
Release
Biomaterials
ranked
among
top
10
journals
citations,
establishing
their
representation.
Key
terms
like
"breast
cancer,"
"nanoparticles,"
"drug
delivery,"
"in-vitro,"
"delivery"
widely
used.
Research
focused
optimizing
drug
targeting,
utilizing
tumor
microenvironment
delivery,
improving
efficiency.
system,
as
an
innovative
approach,
numerous
advantages
has
garnered
global
attention
researchers.
provides
analysis
status
hotspots
within
realm
therapy,
offering
valuable
insights
domain.
ChemistrySelect,
Journal Year:
2023,
Volume and Issue:
8(37)
Published: Oct. 2, 2023
Abstract
The
intention
of
this
study
was
to
prepare
zinc
oxide
nanoparticles
(ZnO‐NPs)
via
bottom‐up
approach
and
evaluate
their
physiochemical,
antimicrobial
anticancer
properties.
ZnO‐NPs
were
first
prepared
by
the
direct
precipitation
method
with
sulphate
heptahydrate,
followed
characterization
tests
using
sophisticated
analytical
imaging
instruments.
Upon
characterization,
studied
for
activities
against
Staphylococcus
aureus,
epidermidis
Pseudomonas
aeruginosa
as
well
activity
breast
cancer
cell
line
(MDA‐MB
231).
possessed
a
mean
particle
diameter
225.2
nm
zeta
potential
−15.8
mV.
A
sharp
absorption
peak
ZnO
recorded
at
354
UV‐Visible
spectroscopy.
Hexagonal
wurtzite
shape
has
been
observed
confirmed
Scanning
Electron
Microscopy
(SEM)
X‐Ray
diffraction
(XRD).
exhibited
excellent
Gram‐positive
bacteria,
aureus
.
In
an
in
vitro
cytotoxicity
study,
showed
dose‐dependent
relationship
MDA‐MB
231
cells.
It
that
concentration
increased
(0.25
μg
35
μg),
there
reduction
proliferation
rate
line.
Overall,
our
reported
successful
synthesis
ZnO‐NPs,
which
can
be
efficient
antibacterial
agents.
