Published: Jan. 1, 2024
Language: Английский
Human Gene, Journal Year: 2024, Volume and Issue: 40, P. 201272 - 201272
Published: Feb. 22, 2024
Language: Английский
Citations
4
Cancers, Journal Year: 2024, Volume and Issue: 16(20), P. 3527 - 3527
Published: Oct. 18, 2024
Deep learning (DL)-based models for predicting the survival of patients with local stages breast cancer only use time-fixed covariates, i.e., patient and data at time diagnosis. These predictions are inherently error-prone because they do not consider time-varying events that occur after initial Our objective is to improve predictive modeling localized both events; thus, we take into account progression a patient's health status over time.
Language: Английский
Citations
2
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: Nov. 1, 2024
This article delves into the intricate interplay between tumors, particularly gynecologic malignancies, and neutrophil extracellular traps (NETs). The relationship specifically NETs is a multifaceted pivotal area of study. Neutrophils, components immune system, are tasked with combating foreign invaders. NETs, structures released by neutrophils, play vital role in systemic infections but also non-infectious conditions such as inflammation, autoimmune diseases, cancer. Cancer cells have ability to attract creating tumor-associated which then stimulate release tumor microenvironment. impact within microenvironment profound intricate. They significant influencing cancer development metastasis, well modulating responses. Through proteases pro-inflammatory cytokines, directly alter behavior cells, increasing invasiveness metastatic potential. Additionally, can trigger epithelial-mesenchymal transition process associated increased invasion metastasis. interaction tumors critical malignancies ovarian, cervical, endometrial Understanding mechanisms through operate these offer valuable insights for targeted therapeutic interventions. Researchers actively working towards harnessing this impede progression opening up new avenues future treatment modalities. As our understanding deepens, it anticipated that novel strategies will emerge, potentially leading improved outcomes patients malignancies. provides comprehensive overview latest research findings on cancer, serving resource exploration field.
Language: Английский
Citations
2
Breast Cancer, Journal Year: 2023, Volume and Issue: 30(6), P. 910 - 925
Published: Aug. 14, 2023
Language: Английский
Citations
5
Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14
Published: Nov. 13, 2024
Bone metastasis is a debilitating complication that frequently occurs in the advanced stages of breast cancer. However, underlying molecular and cellular mechanisms bone remain unclear. Here, we elucidate how arises from tumor cells detach primary lesions infiltrate into surrounding tissue, as well these disseminate to distant sites. Specifically, elaborate preferentially grow within micro-environment interact with facilitate destruction, characterized osteoclastic metastasis, new matrix deposition, osteoblastic metastasis. We also updated current understanding reasons for relapse cancer, opportunities developing novel diagnostic approaches treatment.
Language: Английский
Citations
1
Published: Jan. 1, 2024
Language: Английский
Citations
0