Cyanine dyes in the mitochondria-targeting photodynamic and photothermal therapy

Communications Chemistry, Journal Year: 2024, Volume and Issue: 7(1)

Published: Aug. 13, 2024

Abstract Mitochondrial dysregulation plays a significant role in the carcinogenesis. On other hand, its destabilization strongly represses viability and metastatic potential of cancer cells. Photodynamic photothermal therapies (PDT PTT) target mitochondria effectively, providing innovative non-invasive anticancer therapeutic modalities. Cyanine dyes, with strong mitochondrial selectivity, show enhancing PDT PTT. The limitations cyanine dyes for PTT are discussed, along their applications combination therapies, theranostic techniques, optimal delivery systems. Additionally, novel approaches sonodynamic therapy using photoactive presented, highlighting advances treatment.

Language: Английский

---

The therapeutic role of γδT cells in TNBC

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: June 12, 2024

Triple-negative breast cancer (TNBC) is a subtype of that presents significant therapeutic challenges due to the absence estrogen receptor (ER), progesterone (PR), and human epidermal growth factor 2 (HER2) expression. As result, conventional hormonal targeted therapies are largely ineffective, underscoring urgent need for novel treatment strategies. γδT cells, known their robust anti-tumor properties, show considerable potential in TNBC as they can identify eliminate tumor cells without reliance on MHC restrictions. These demonstrate extensive proliferation both vitro vivo , directly target tumors through cytotoxic effects or indirectly by promoting other immune responses. Studies suggest expansion adoptive transfer strategies targeting Vδ2 Vδ1 cell subtypes have shown promise preclinical models. This review compiles discusses existing literature primary subgroups roles therapy, contributions cytotoxicity modulation, proposes future cell-based immunotherapies TNBC.

Language: Английский

---

Lipoxygenases at the Intersection of Infection and Carcinogenesis

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 3961 - 3961

Published: April 2, 2024

The persisting presence of opportunistic pathogens like Pseudomonas aeruginosa poses a significant threat to many immunocompromised cancer patients with pulmonary infections. This review highlights the complexity interactions in host's defensive eicosanoid signaling network and its hijacking by pathogenic bacteria their own advantage. Human lipoxygenases (ALOXs) mouse counterparts are integral elements innate immune system, mostly operating pro-inflammatory mode. Taking into account indispensable role inflammation carcinogenesis, have counteracting roles this process. In addition describing structure-function review, we discuss such critical processes as cell signaling, metastases, death cells through ferroptosis, well ALOXs carcinogenesis promoted Finally, perspectives novel oncotherapeutic approaches harness lipoxygenase tumors.

Language: Английский

---

Lipidomics and metabolomics as potential biomarkers for breast cancer progression

npj Metabolic Health and Disease, Journal Year: 2024, Volume and Issue: 2(1)

Published: Sept. 2, 2024

Breast cancer is the most prevalent among women in United States, representing ~30% of all new female cases annually. For year 2024, it estimated that 310,720 instances invasive breast will be diagnosed, and responsible for over 42,000 deaths women. Today, despite availability numerous treatments its symptoms, cancer-related result from metastasis which there no treatment. This emphasizes importance early detection treatment before spreads. initial staging cancer, clinicians routinely employ mammography ultrasonography, which, while effective broad screening, have limitations sensitivity specificity. Advanced biomarkers could significantly enhance precision detection, enable more accurate monitoring disease evolution, facilitate development personalized plans tailored to specific molecular profile each tumor. would not only improve therapeutic outcomes, but also help avoiding overtreatment associated side effects, thereby improving quality life patients. Thus, pursuit novel biomarkers, potentially encompassing metabolomic lipidomic signatures, essential advancing diagnosis In this brief review, we provide an overview current translational potential metabolic predicting prognosis response therapy.

Language: Английский

---

Expanding Spatial Metabolomics Coverage with Lithium-Doped Nanospray Desorption Electrospray Ionization Mass Spectrometry Imaging

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(46), P. 18427 - 18436

Published: Nov. 6, 2024

Spatial metabolomics has emerged as a powerful tool capable of revealing metabolic gradients throughout complex heterogeneous tissues. While mass spectrometry imaging (MSI) technologies designed to generate spatial metabolomic data have improved significantly over time, metabolite coverage is still significant limitation. It possible achieve deeper by in positive and negative polarities or several serial sections with different targeted biomolecular classes. However, this increases the number tissue samples required for biological studies reduces capacity larger sample cohorts. Herein, we introduce lithium-doped nanospray desorption electrospray ionization (nano-DESI) simple robust method increase coverage, which achieved through enhancements efficiencies ion mode metabolites lipids lacking basic moieties, structurally diagnostic tandem spectra [M + Li]

Language: Английский

---

The potential impact of dietary choices on melanoma risk: an anti-inflammatory diet

Genes & Nutrition, Journal Year: 2024, Volume and Issue: 19(1)

Published: May 23, 2024

Abstract The role of inflammation in the aetiology cancer is recognized. However, no study yet examined association between an anti-inflammatory diet and cutaneous melanoma explored whether it could be modified by genetic variations cyclooxygenase-2 (COX-2), a key enzyme inflammation. A case-control was conducted IDI-IRCCS hospital Rome, Italy with 273 cases primary 269 controls frequency matched to cases. Information on socio-demographic pigmentary characteristics, medical history, sun exposure dietary habits were collected for all subjects. − 765G > C polymorphism identified DNA extracted from blood samples. An score created. Logistic regression models fitted obtain odds ratios (ORs) 95% confidence intervals (CIs). high (≥ 8 items) associated decreased risk (OR: 0.29; 95%CI: 0.17–0.49, P trend < 0.0001) after adjusting sex, age, education, number common nevi, skin photo-type, solar lentigines sunburns childhood. COX-2 -765 G not independent factor melanoma. Although interaction genotypes statistically significant ( p = 0.25), when stratified effect slightly more pronounced participants carrying – 765GG 0.17; 0.06–0.47, 0.001). Our findings suggest that adherence developing These results potential impact choices risk.

Language: Английский

---

Novel Benzimidazole Derivatives as Potent Inhibitors of Microsomal Prostaglandin E₂ Synthase 1 for the Potential Treatment of Inflammation, Pain, and Fever

Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 2, 2024

Microsomal prostaglandin E2 synthase 1 (mPGES-1) is a promising target for treating inflammatory diseases and pain. This study introduces novel series of benzimidazoles, with the most potent analogs exhibiting IC50 values 0.27–7.0 nM in cell-free assay (PG)E2 production. Compound 44 (AGU654) demonstrated remarkable selectivity mPGES-1 (IC50 = 2.9 nM) over COX-1, COX-2, 5-LOX, FLAP, along excellent bioavailability. Metabololipidomics analysis activated human monocyte-derived macrophages whole blood revealed that AGU654 selectively suppresses PGE2 production triggered by bacterial exotoxins while sparing other prostaglandins. Furthermore, vivo studies showed significantly alleviated fever, inflammation, pain preclinical guinea pig models, suggesting it could be an effective strategy managing diseases. In conclusion, these benzimidazole derivatives warrant further exploration into new alternative analogs, potentially uncovering compounds favorable pharmacological profile possessing significant anti-inflammatory analgesic properties.

Language: Английский

---

Role of Microenvironmental Components in Head and Neck Squamous Cell Carcinoma

Journal of Personalized Medicine, Journal Year: 2023, Volume and Issue: 13(11), P. 1616 - 1616

Published: Nov. 17, 2023

Head and neck squamous cell cancer (HNSCC) is one of the ten most common malignant neoplasms, characterized by an aggressive course, high recurrence rate, poor response to treatment, low survival rate. This creates need for a deeper understanding mechanisms pathogenesis this cancer. The tumor microenvironment (TME) HNSCC consists stromal immune cells, blood lymphatic vessels, extracellular matrix. It known that complex relationships between cells TME components. components their dynamic interactions with enhance adaptation environment, which provides highly potential resistance antitumor therapy. Basic research aimed at studying role in carcinogenesis may serve as key discovery both new biomarkers–predictors prognosis targets drugs. review article focuses on interaction such newly formed cancer-associated fibroblasts,

Language: Английский

---

Prostaglandin analogues signal detection by data mining in the FDA Adverse Event Reporting System database

BMJ Open Ophthalmology, Journal Year: 2024, Volume and Issue: 9(1), P. e001764 - e001764

Published: Aug. 1, 2024

Objective This study aims to identify safety signals of ophthalmic prostaglandin analogues through data mining the Food and Drug Administration Adverse Event Reporting System (FAERS) database. Methods A search by proportional reporting ratio, OR, Bayesian confidence propagation neural network, information component 0.25 χ 2 for detection was conducted FAERS database following medications: latanoprost, travoprost, tafluprost bimatoprost. Results 12 preferred terms were statistically associated: diabetes mellitus, n=2; hypoacusis, malignant mediastinal neoplasm, n=1; blood immunoglobulin E increased, cataract, blepharospasm, full count abnormal, skin exfoliation, chest discomfort, dry mouth, n=1. Limitation The database’s limitations, such as undetermined causality cases, under-reporting lack restriction only health professionals this type event, could modify statistical outcomes. These limitations are particularly relevant in context drug analysis, they can affect accuracy reliability data, potentially leading biased or incomplete results. Conclusions Our findings have revealed a potential relationship due biological plausibility among cataracts, discomfort mouth; therefore, it is continue investigating possible drug-event association, whether refute signal new risk.

Language: Английский

---

CONTRIBUIÇÃO DO DIAGNÓSTICO POR IMAGEM PARA A CIÊNCIA FORENSE

Published: Aug. 28, 2023

Background: Patient-centered clinical method (PCCM) is, nowadays, one of the most essential precepts taught during medical education and has gradually replaced biomedical model-based education.PCCM aims not only to treat disease but contemplate individual themselves conjointly, comprehending their experience with in all its contexts.Objective: To report experiences lived by students practical application PCCM, through home visits.Methods: A descriptive, qualitative study, type report, regarding activities carried out at a Family Health Unit (FHU) city Vitoria -ES, based on visits family nucleus.Experience report: Using Person-Centered Clinical Method visits, explored feelings impacts experienced assisted health-disease process members.They also considered social context which patient was involved, identifying support provided members friends as facilitator journey coping illnesses.Based this experience, project facilitated development strategies intervention aimed improving health members, involving multidisciplinary team such healthcare agents, doctors, physiotherapists.Conclusion: The critical role welcoming reliable environment among students, future ascertained, hence allowing illness personal life stories, besides these exchanges being necessary implementation more integral care process, is evidenced PCCM.

Language: Английский

---