Preoperative 11C-Methionine PET-MRI in Pediatric Infratentorial Tumors DOI Creative Commons

Pierre-Aurélien Beuriat,

Anthime Flaus, Aurélie Portefaix

et al.

Clinical Nuclear Medicine, Journal Year: 2024, Volume and Issue: 49(5), P. 381 - 386

Published: March 15, 2024

Purpose MRI is the main imaging modality for pediatric brain tumors, but amino acid PET can provide additional information. Simultaneous PET-MRI acquisition allows to fully assess tumor and lower radiation exposure. Although symptomatic posterior fossa tumors are typically resected, patient management evolving will benefit from an improved preoperative characterization. We aimed explore, in children with newly diagnosed tumor, complementarity of information provided by parameters correlation histopathological results. Patients Methods Children a prospectively underwent 11 C-methionine (MET) PET-MRI. Images were assessed visually semiquantitatively. Using correlation, minimum apparent diffusion coefficient (ADC min ) contrast enhancement compared MET SUV max . The diameter enhancing lesions was metabolic tumoral volume. Lesions classified according 2021 World Health Organization (WHO) classification. Results Ten included 4 pilocytic astrocytomas, 2 medulloblastomas, 1 ganglioglioma, central nervous system embryonal schwannoma. All showed increased uptake. A negative moderate found between ADC values ( r = −0.39). Mean 3.8 (range, 3.3–4.2) WHO grade versus 2.5 1.7–3.0) lesions. positive volume 0.34). There no intensity −0.15). Conclusions Preoperative C-MET could complementary characterize infratentorial tumors.

Language: Английский

Challenges, limitations, and pitfalls of PET and advanced MRI in patients with brain tumors: A report of the PET/RANO group DOI
Norbert Galldiks, Timothy J. Kaufmann, Philipp Kickingereder

et al.

Neuro-Oncology, Journal Year: 2024, Volume and Issue: 26(7), P. 1181 - 1194

Published: March 11, 2024

Abstract Brain tumor diagnostics have significantly evolved with the use of positron emission tomography (PET) and advanced magnetic resonance imaging (MRI) techniques. In addition to anatomical MRI, these modalities may provide valuable information for several clinical applications such as differential diagnosis, delineation extent, prognostication, differentiation between relapse treatment-related changes, evaluation response anticancer therapy. particular, joint recommendations Response Assessment in Neuro-Oncology (RANO) Group, European Association Neuro-oncology, major American Nuclear Medicine societies highlighted that additional value radiolabeled amino acids compared MRI alone is outstanding its widespread should be supported. For steadily increasing practice, Standardization Subcommittee Jumpstarting Tumor Drug Development Coalition provided more recently an updated acquisition protocol widely used dynamic susceptibility contrast perfusion MRI. Besides acid PET other tracers techniques (e.g. MR spectroscopy) are considerable interest increasingly integrated into everyday practice. Nevertheless, shortcomings which considered routine. This comprehensive review provides overview potential challenges, limitations, pitfalls associated patients gliomas or brain metastases. Despite issues, continue play indispensable role management. Acknowledging mitigating challenges through interdisciplinary collaboration, standardized protocols, continuous innovation will further enhance utility guiding optimal patient care.

Language: Английский

Citations

17
Exosomes in Glioma: Unraveling Their Roles in Progression, Diagnosis, and Therapy DOI Open Access
Yang Song,

Yumeng Sun,

Wei Liu

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(4), P. 823 - 823

Published: Feb. 18, 2024

Gliomas, the most prevalent primary malignant brain tumors, present a challenging prognosis even after undergoing surgery, radiation, and chemotherapy. Exosomes, nano-sized extracellular vesicles secreted by various cells, play pivotal role in glioma progression contribute to resistance against chemotherapy radiotherapy facilitating transportation of biological molecules promoting intercellular communication within tumor microenvironment. Moreover, exosomes exhibit remarkable ability traverse blood–brain barrier, positioning them as potent carriers for therapeutic delivery. These attributes hold promise enhancing diagnosis, prognosis, treatment. Recent years have witnessed significant advancements exosome research realm tumors. In this article, we primarily focus on elucidating development, highlighting latest breakthroughs diagnostic approaches, outlining prospective directions future research.

Language: Английский

Citations

10
Advanced Imaging in the Diagnosis and Response Assessment of High-Grade Glioma: AJR Expert Panel Narrative Review DOI
Leland Hu, Marion Smits, Timothy J. Kaufmann

et al.

American Journal of Roentgenology, Journal Year: 2024, Volume and Issue: unknown

Published: March 13, 2024

This AJR Expert Panel Narrative explores the current status of advanced MRI and PET techniques for post-therapeutic response assessment high-grade adult-type gliomas, focusing on ongoing clinical controversies in practice. Discussed that complement conventional aid differentiation recurrent tumor from post-treatment effects include DWI diffusion tensor imaging; perfusion including dynamic susceptibility contrast (DSC), contrast-enhanced MRI, arterial spin labeling; MR spectroscopy 2-hydroxyglutarate (2HG) concentration; glucose- amino acid (AA)-based PET; amide proton transfer imaging. Updated criteria Response Assessment Neuro-Oncology are presented. Given abundant supporting evidence, panel supports a recommendation routine after HGG treatment should particularly given development consensus recommended DSC-MRI protocol. Although published studies support 2HG MRS AA PET, these techniques' widespread adoption will likely require increased availability (for MRS) or insurance funding United States PET). The article concludes with series opinions author panel, centered integration imaging into posttreatment surveillance protocols.

Language: Английский

Citations

3
An effective MRI perfusion threshold based workflow to triage additional 18F-FET PET in posttreatment high grade glioma DOI Creative Commons
Krishna K. Kadali, Nathalie Nierobisch,

Fabienne Maibach

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 5, 2025

MRI is the preferred method for follow-up imaging of post-treatment WHO grade 3 or 4 gliomas. While positron emission tomography with O-(2-[18F]fluoroethyl)-L-tyrosine) (18F-FET PET) offers higher diagnostic accuracy, its use limited due to low availability. We propose a sequential, threshold-based workflow triage patients additional 18F-FET PET scans based on dynamic susceptibility contrast (DSC) perfusion-derived rCBV values, optimize resource allocation. Patients high-grade gliomas who had undergone standard-of-care treatment and developed new enlarging contrast-enhancing lesions were included, study performed within months MRI. excluded if there significant changes in lesion size between scan. An threshold was determined performance evaluated compared gold standard defined here as surgical verification long-term without further intervention. Forty-one total 49 included (tumor progression n = 40, treatment-related 9). Above 2.4, 100% accurate (21/21 patients) diagnosing tumor progression. Below threshold, identified 9 true negatives but produced 19 false negatives. reclassified 18/19 (95%) resulting an overall accuracy 48/49 (98%) workflow. Our DSC perfusion rCBV-based triaging high glioma has potential

Language: Английский

Citations

0
Adding Value to Liquid Biopsy for Brain Tumors: The Role of Imaging DOI Open Access
Nastaran Khalili,

Hossein Shooli,

Nastaran Hosseini

et al.

Cancers, Journal Year: 2023, Volume and Issue: 15(21), P. 5198 - 5198

Published: Oct. 29, 2023

Clinical management in neuro-oncology has changed to an integrative approach that incorporates molecular profiles alongside histopathology and imaging findings. While the World Health Organization (WHO) guideline recommends genotyping of informative alterations as a routine clinical practice for central nervous system (CNS) tumors, acquisition tumor tissue CNS is invasive not always possible. Liquid biopsy non-invasive provides opportunity capture complex heterogeneity whole through detection circulating biomarkers body fluids, such blood or cerebrospinal fluid (CSF). Despite all advantages, low abundance tumor-derived biomarkers, particularly well their short half-life limited application liquid practice. Thus, it crucial identify factors associated with presence these explore possible strategies can increase shedding tumoral components into biological fluids. In this review, we first describe applications including its roles early recurrence monitoring treatment response. We then discuss utilization identifying affect how image-guided interventions focused ultrasound help enhance blood–brain barrier (BBB) disruption.

Language: Английский

Citations

7
Neuro-Oncology and Positron Emission Tomography: “Just Can’t Get Enough” DOI Open Access
Barbara Muoio, Vittoria Espeli, Giorgio Treglia

et al.

Cancers, Journal Year: 2023, Volume and Issue: 15(19), P. 4739 - 4739

Published: Sept. 27, 2023

Imaging has a pivotal role in neuro-oncology for the management of primary and secondary brain tumors [...].

Language: Английский

Citations

3
Introduction to the Special Issue on “Role of Novel Imaging Technique in Brain Tumors” DOI Open Access
Ali Nabavizadeh

Cancers, Journal Year: 2024, Volume and Issue: 16(3), P. 575 - 575

Published: Jan. 30, 2024

In recent years, significant strides have been made in the field of neuro-oncology imaging, contributing to our understanding and management brain tumors [...]

Language: Английский

Citations

0
Preoperative 11C-Methionine PET-MRI in Pediatric Infratentorial Tumors DOI Creative Commons

Pierre-Aurélien Beuriat,

Anthime Flaus, Aurélie Portefaix

et al.

Clinical Nuclear Medicine, Journal Year: 2024, Volume and Issue: 49(5), P. 381 - 386

Published: March 15, 2024

Purpose MRI is the main imaging modality for pediatric brain tumors, but amino acid PET can provide additional information. Simultaneous PET-MRI acquisition allows to fully assess tumor and lower radiation exposure. Although symptomatic posterior fossa tumors are typically resected, patient management evolving will benefit from an improved preoperative characterization. We aimed explore, in children with newly diagnosed tumor, complementarity of information provided by parameters correlation histopathological results. Patients Methods Children a prospectively underwent 11 C-methionine (MET) PET-MRI. Images were assessed visually semiquantitatively. Using correlation, minimum apparent diffusion coefficient (ADC min ) contrast enhancement compared MET SUV max . The diameter enhancing lesions was metabolic tumoral volume. Lesions classified according 2021 World Health Organization (WHO) classification. Results Ten included 4 pilocytic astrocytomas, 2 medulloblastomas, 1 ganglioglioma, central nervous system embryonal schwannoma. All showed increased uptake. A negative moderate found between ADC values ( r = −0.39). Mean 3.8 (range, 3.3–4.2) WHO grade versus 2.5 1.7–3.0) lesions. positive volume 0.34). There no intensity −0.15). Conclusions Preoperative C-MET could complementary characterize infratentorial tumors.

Language: Английский

Citations

0